Thrombospondin 4

Last updated
THBS4
Identifiers
Aliases THBS4 , TSP4, TSP-4, thrombospondin 4
External IDs OMIM: 600715 MGI: 1101779 HomoloGene: 20691 GeneCards: THBS4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001306212
NM_001306213
NM_001306214
NM_003248

NM_011582

RefSeq (protein)

NP_001293141
NP_001293142
NP_001293143
NP_003239

NP_035712

Location (UCSC) Chr 5: 79.99 – 80.08 Mb Chr 13: 92.75 – 92.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene. [5] [6]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. This protein may be involved in local signaling in the developing and adult nervous system, in bone formation and fracture healing, and in osteoarthritis. [6]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. doi: 10.1074/jbc.270.6.2809 . PMID   7852353.
  6. 1 2 "Entrez Gene: THBS4 thrombospondin 4".

Further reading