Thrombospondin 4

Last updated
THBS4
Identifiers
Aliases THBS4 , TSP4, TSP-4, thrombospondin 4
External IDs OMIM: 600715 MGI: 1101779 HomoloGene: 20691 GeneCards: THBS4
Gene location (Human)
Ideogram human chromosome 5.svg
Chr. Chromosome 5 (human) [1]
Human chromosome 5 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 5q14.1Start79,991,311 bp [1]
End80,083,287 bp [1]
RNA expression pattern
PBB GE THBS4 204776 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001306212
NM_001306213
NM_001306214
NM_003248

NM_011582

RefSeq (protein)

NP_001293141
NP_001293142
NP_001293143
NP_003239

NP_035712

Location (UCSC) Chr 5: 79.99 – 80.08 Mb Chr 13: 92.75 – 92.79 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene. [5] [6]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. [6]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. doi: 10.1074/jbc.270.6.2809 . PMID   7852353.
  6. 1 2 "Entrez Gene: THBS4 thrombospondin 4".

Further reading