Toshifumi Ohkusa

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  1. 1 2 3 "Biography - ORCID". ORCID. Retrieved September 26, 2025.
  2. 1 2 "Toshifumi Ohkusa". Google Scholar. Retrieved September 26, 2025.
  3. ↑ Okayasu, I.; Hatakeyama, S.; Yamada, M.; Ohkusa, T.; Inagaki, Y.; Nakaya, R. (March 1990). "A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice". Gastroenterology. 98 (3): 694–702. doi:10.1016/0016-5085(90)90290-h. ISSN   0016-5085. PMID   1688816.
  4. ↑ Yamada, M.; Ohkusa, T.; Okayasu, I. (November 1992). "Occurrence of dysplasia and adenocarcinoma after experimental chronic ulcerative colitis in hamsters induced by dextran sulphate sodium". Gut. 33 (11): 1521–1527. doi:10.1136/gut.33.11.1521. ISSN   0017-5749. PMC   1379539 . PMID   1333439.
  5. ↑ Okayasu, I.; Ohkusa, T.; Kajiura, K.; Kanno, J.; Sakamoto, S. (July 1996). "Promotion of colorectal neoplasia in experimental murine ulcerative colitis". Gut. 39 (1): 87–92. doi:10.1136/gut.39.1.87. ISSN   0017-5749. PMC   1383238 . PMID   8881816.
  6. ↑ Kajiura, K.; Ohkusa, T.; Okayasu, I. (1998). "Relationship between fecal bile acids and the occurrence of colorectal neoplasia in experimental murine ulcerative colitis". Digestion. 59 (1): 69–72. doi:10.1159/000007469. ISSN   0012-2823. PMID   9468101.
  7. ↑ Okayasu, Isao; Yamada, Masahiro; Mikami, Tetuo; Yoshida, Tsutomu; Kanno, Jun; Ohkusa, Toshifumi (October 2002). "Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model". Journal of Gastroenterology and Hepatology. 17 (10): 1078–1083. doi:10.1046/j.1440-1746.2002.02853.x. ISSN   0815-9319. PMID   12201867.
  8. ↑ Fujiwara, Mutsunori; Kaneko, Tsutomu; Iwana, Hirokazu; Taketomo, Naoki; Tsunoo, Hajime; Kanno, Jun; Ohkusa, Toshifumi; Okayasu, Isao (2003). "Inhibitory effects of Bifidobacterium longum on experimental ulcerative colitis induced in mice by synthetic dextran sulfate sodium". Digestion. 67 (1–2): 90–95. doi:10.1159/000069704. ISSN   0012-2823. PMID   12743446.
  9. ↑ Shibahara-Sone, H.; Gomi, A.; Iino, T.; Kano, M.; Nonaka, C.; Watanabe, O.; Miyazaki, K.; Ohkusa, T. (June 2016). "Living cells of probiotic Bifidobacterium bifidum YIT 10347 detected on gastric mucosa in humans". Beneficial Microbes. 7 (3): 319–326. doi:10.3920/BM2015.0138. ISSN   1876-2891. PMID   26925600.
  10. ↑ Takeda, Tsutomu; Asaoka, Daisuke; Nojiri, Shuko; Yanagisawa, Naotake; Nishizaki, Yuji; Osada, Taro; Koido, Shigeo; Nagahara, Akihito; Katsumata, Noriko; Odamaki, Toshitaka; Xiao, Jin-Zhong; Ohkusa, Toshifumi; Sato, Nobuhiro (1 March 2023). "Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial". The American Journal of Gastroenterology. 118 (3): 561–568. doi:10.14309/ajg.0000000000002028. ISSN   1572-0241. PMC   9973440 . PMID   36216361.
  11. ↑ Endo, S.; Ohkusa, T.; Saito, Y.; Fujiki, K.; Okayasu, I.; Sato, C. (1 May 1995). "Detection of Helicobacter pylori infection in early-stage gastric cancer. A comparison between intestinal- and diffuse-type gastric adenocarcinomas". Cancer. 75 (9): 2203–2208. doi:10.1002/1097-0142(19950501)75:9<2203::aid-cncr2820750903>3.0.co;2-6. ISSN   0008-543X. PMID   7536119.
  12. ↑ Suzuki, S.; Ohkusa, T.; Shimoi, K.; Horiuchi, T.; Fujiki, K.; Takashimizu, I. (December 1997). "Disappearance of multiple hyperplastic polyps after the eradication of Helicobacter pylori". Gastrointestinal Endoscopy. 46 (6): 566–568. doi:10.1016/s0016-5107(97)70020-8. ISSN   0016-5107. PMID   9434232.
  13. ↑ Ohkusa, T.; Takashimizu, I.; Fujiki, K.; Suzuki, S.; Shimoi, K.; Horiuchi, T.; Sakurazawa, T.; Ariake, K.; Ishii, K.; Kumagai, J.; Tanizawa, T. (1 November 1998). "Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial". Annals of Internal Medicine. 129 (9): 712–715. doi:10.7326/0003-4819-129-9-199811010-00006. ISSN   0003-4819. PMID   9841603.
  14. ↑ Ohkusa, Toshifumi; Miwa, Hiroto; Hojo, Mariko; Kumagai, Jiro; Tanizawa, Toru; Asaoka, Daisuke; Terai, Takeshi; Ohkura, Ryuichi; Sato, Nobuhiro (2003). "Endoscopic, histological and serologic findings of gastric hyperplastic polyps after eradication of Helicobacter pylori: comparison between responder and non-responder cases". Digestion. 68 (2–3): 57–62. doi:10.1159/000074516. ISSN   0012-2823. PMID   14581761.
  15. ↑ Ohkusa, T.; Fujiki, K.; Takashimizu, I.; Kumagai, J.; Tanizawa, T.; Eishi, Y.; Yokoyama, T.; Watanabe, M. (6 March 2001). "Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated". Annals of Internal Medicine. 134 (5): 380–386. doi:10.7326/0003-4819-134-5-200103060-00010. ISSN   0003-4819. PMID   11242498.
  16. ↑ Ohkusa, T.; Okayasu, I.; Miwa, H.; Ohtaka, K.; Endo, S.; Sato, N. (June 2003). "Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils". Gut. 52 (6): 797–803. doi:10.1136/gut.52.6.797. ISSN   0017-5749. PMC   1773688 . PMID   12740333.
  17. ↑ Murakami, Kazunari; Furuta, Takahisa; Ando, Takashi; Nakajima, Takeshi; Inui, Yoshikatsu; Oshima, Tadayuki; Tomita, Toshihiko; Mabe, Katsuhiro; Sasaki, Makoto; Suganuma, Takanori; Nomura, Hideyuki; Satoh, Kiichi; Hori, Shinichiro; Inoue, Syuuji; Tomokane, Takeshi; Kudo, Mineo; Inaba, Tomoki; Take, Susumu; Ohkusa, Toshifumi; Yamamoto, Shojiro; Mizuno, Shigeaki; Kamoshida, Toshiro; Amagai, Kenji; Iwamoto, Junichi; Miwa, Jun; Kodama, Masaaki; Okimoto, Tadayoshi; Kato, Mototsugu; Asaka, Masahiro (October 2013). "Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan". Journal of Gastroenterology. 48 (10): 1128–1135. doi:10.1007/s00535-012-0731-8. ISSN   1435-5922. PMID   23307042.
  18. ↑ Asaoka, Daisuke; Nagahara, Akihito; Matsuhisa, Takeshi; Takahashi, Shin-Ichi; Tokunaga, Kengo; Kawai, Takashi; Kawakami, Kohei; Suzuki, Hidekazu; Suzuki, Masayuki; Nishizawa, Toshihiro; Kurihara, Naoto; Ito, Masayoshi; Sasaki, Hitoshi; Omata, Fumio; Mizuno, Shigeaki; Torii, Akira; Ohkusa, Toshifumi; Mine, Tetsuya; Sakaki, Nobuhiro (December 2013). "Trends of second-line eradication therapy for Helicobacter pylori in Japan: a multicenter study in the Tokyo metropolitan area". Helicobacter. 18 (6): 468–472. doi:10.1111/hel.12063. ISSN   1523-5378. PMID   23773231.
  19. ↑ Kawai, Takashi; Takahashi, Shin'ichi; Suzuki, Hidekazu; Sasaki, Hitoshi; Nagahara, Akihito; Asaoka, Daisuke; Matsuhisa, Takeshi; Masaoaka, Tatsuhiro; Nishizawa, Toshihiro; Suzuki, Masayuki; Ito, Masayoshi; Kurihara, Naoto; Omata, Fumio; Mizuno, Shigeaki; Torii, Akira; Kawakami, Kohei; Ohkusa, Toshifumi; Tokunaga, Kengo; Mine, Tetsuya; Sakaki, Nobuhiro (December 2014). "Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group)". Journal of Gastroenterology and Hepatology. 29 Suppl 4: 29–32. doi:10.1111/jgh.12796. ISSN   1440-1746. PMID   25521730.
  20. ↑ Iwata, Eri; Sugimoto, Mitsushige; Asaoka, Daisuke; Hojo, Mariko; Ito, Masayoshi; Kitazawa, Naoko; Kurihara, Naoto; Masaoka, Tatsuhiro; Mizuno, Shigeaki; Mori, Hideki; Nagahara, Akihito; Niikura, Ryota; Ohkusa, Toshifumi; Sano, Masaya; Shimada, Yuji; Suzuki, Hidekazu; Takeuchi, Yoshiaki; Tanaka, Akifumi; Tokunaga, Kengo; Ueda, Kumiko; Sakaki, Nobuhiro; Takahashi, Shin'ichi; Kawai, Takashi (2024). "Characteristics of Helicobacter pylori Eradication Therapy in Patients 80 Years or Older Living in a Metropolitan Area: A Multicenter Retrospective Study". Helicobacter. 29 (4) e13125. doi:10.1111/hel.13125. ISSN   1523-5378. PMID   39152662.
  21. ↑ Ohkusa, T.; Okayasu, I.; Tokoi, S.; Ozaki, Y. (1993). "Bacterial invasion into the colonic mucosa in ulcerative colitis". Journal of Gastroenterology and Hepatology. 8 (1): 116–118. doi:10.1111/j.1440-1746.1993.tb01184.x. ISSN   0815-9319. PMID   8439657.
  22. ↑ Ohkusa, Toshifumi; Sato, Nobuhiro; Ogihara, Tatuo; Morita, Koji; Ogawa, Masayuki; Okayasu, Isao (August 2002). "Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody". Journal of Gastroenterology and Hepatology. 17 (8): 849–853. doi:10.1046/j.1440-1746.2002.02834.x. ISSN   0815-9319. PMID   12164960.
  23. ↑ Ohkusa, T.; Okayasu, I.; Ogihara, T.; Morita, K.; Ogawa, M.; Sato, N. (January 2003). "Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis". Gut. 52 (1): 79–83. doi:10.1136/gut.52.1.79. ISSN   0017-5749. PMC   1773498 . PMID   12477765.
  24. ↑ Ohkusa, Toshifumi; Yoshida, Tsutomu; Sato, Nobuhiro; Watanabe, Sumio; Tajiri, Hisao; Okayasu, Isao (May 2009). "Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis". Journal of Medical Microbiology. 58 (Pt 5): 535–545. doi:10.1099/jmm.0.005801-0. ISSN   0022-2615. PMC   2887547 . PMID   19369513.
  25. ↑ Yukawa, Toyokazu; Ohkusa, Toshifumi; Shibuya, Tomoyoshi; Tsukinaga, Shintaro; Mitobe, Jimi; Takakura, Kazuki; Takahara, Akitaka; Odahara, Shunichi; Matsudaira, Hiroshi; Nagatsuma, Keisuke; Kitahara, Takuya; Kajihara, Mikio; Uchiyama, Kan; Arakawa, Hiroshi; Koido, Shigeo; Tajiri, Hisao (2013). "Nested culture method improves detection of Fusobacterium from stool in patients with ulcerative colitis". Japanese Journal of Infectious Diseases. 66 (2): 109–114. doi:10.7883/yoken.66.109. ISSN   1884-2836. PMID   23514906.
  26. ↑ Sekizuka, Tsuyoshi; Ogasawara, Yumiko; Ohkusa, Toshifumi; Kuroda, Makoto (2017). "Characterization of Fusobacterium varium Fv113-g1 isolated from a patient with ulcerative colitis based on complete genome sequence and transcriptome analysis". PLOS ONE. 12 (12) e0189319. Bibcode:2017PLoSO..1289319S. doi: 10.1371/journal.pone.0189319 . ISSN   1932-6203. PMC   5720691 . PMID   29216329.
  27. ↑ Hojo, Mariko; Ohkusa, Toshifumi; Tomeoku, Harumi; Koido, Shigeo; Asaoka, Daisuke; Nagahara, Akihito; Watanabe, Sumio (21 September 2011). "Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria". World Journal of Gastroenterology. 17 (35): 4017–4022. doi: 10.3748/wjg.v17.i35.4017 . ISSN   2219-2840. PMC   3199561 . PMID   22046091.
  28. ↑ Koido, Shigeo; Ohkusa, Toshifumi; Saito, Hiroaki; Yokoyama, Tetsuji; Shibuya, Tomoyoshi; Sakamoto, Naoto; Uchiyama, Kan; Arakawa, Hiroshi; Osada, Taro; Nagahara, Akihito; Watanabe, Sumio; Tajiri, Hisao (21 December 2013). "Seasonal variations in the onset of ulcerative colitis in Japan". World Journal of Gastroenterology. 19 (47): 9063–9068. doi: 10.3748/wjg.v19.i47.9063 . ISSN   2219-2840. PMC   3870560 . PMID   24379632.
  29. ↑ Koido, Shigeo; Ohkusa, Toshifumi; Takakura, Kazuki; Odahara, Shunichi; Tsukinaga, Shintaro; Yukawa, Toyokazu; Mitobe, Jimi; Kajihara, Mikio; Uchiyama, Kan; Arakawa, Hiroshi; Tajiri, Hisao (7 December 2013). "Clinical significance of serum procalcitonin in patients with ulcerative colitis". World Journal of Gastroenterology. 19 (45): 8335–8341. doi: 10.3748/wjg.v19.i45.8335 . ISSN   2219-2840. PMC   3857457 . PMID   24363525.
  30. ↑ Koido, Shigeo; Ohkusa, Toshifumi; Kan, Shin; Takakura, Kazuki; Saito, Keisuke; Komita, Hideo; Ito, Zensho; Kobayashi, Hiroko; Takami, Shinichiro; Uchiyama, Kan; Arakawa, Hiroshi; Ito, Masaki; Okamoto, Masato; Kajihara, Mikio; Homma, Sadamu; Tajiri, Hisao (21 October 2014). "Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine". World Journal of Gastroenterology. 20 (39): 14420–14429. doi: 10.3748/wjg.v20.i39.14420 . ISSN   2219-2840. PMC   4202370 . PMID   25339828.
  31. ↑ Miyauchi, Eiji; Taida, Takashi; Uchiyama, Kan; Nakanishi, Yumiko; Kato, Tamotsu; Koido, Shigeo; Sasaki, Nobuo; Ohkusa, Toshifumi; Sato, Nobuhiro; Ohno, Hiroshi (25 August 2025). "Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota". Gut. doi:10.1136/gutjnl-2025-334922. ISSN   0017-5749. PMID   40854688.
  32. ↑ Ohkusa, Toshifumi; Sato, Nobuhiro; Ogihara, Tatuo; Morita, Koji; Ogawa, Masayuki; Okayasu, Isao (August 2002). "Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody". Journal of Gastroenterology and Hepatology. 17 (8): 849–853. doi:10.1046/j.1440-1746.2002.02834.x. ISSN   0815-9319. PMID   12164960.
  33. ↑ Ohkusa, Toshifumi; Kato, Kimitoshi; Terao, Shuichi; Chiba, Toshimi; Mabe, Katsuhiro; Murakami, Kazunari; Mizokami, Yuji; Sugiyama, Toshiro; Yanaka, Akinori; Takeuchi, Yoshiaki; Yamato, Shigeru; Yokoyama, Tetsuji; Okayasu, Isao; Watanabe, Sumio; Tajiri, Hisao; Sato, Nobuhiro (August 2010). "Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial". The American Journal of Gastroenterology. 105 (8): 1820–1829. doi:10.1038/ajg.2010.84. ISSN   1572-0241. PMID   20216533.
  34. ↑ Terao, Shuichi; Yamashiro, Kenzo; Tamura, Isamu; Hirano, Takahiro; Ohkusa, Toshifumi; Kato, Kimitoshi (2011). "Antibiotic combination therapy for steroid withdrawal in steroid-dependent ulcerative colitis". Digestion. 83 (3): 198–203. doi:10.1159/000321811. ISSN   1421-9867. PMID   21266816.
  35. ↑ Nishikawa, Yuriko; Ohkusa, Toshifumi; Shibuya, Tomoyoshi; Osada, Taro; Uchiyama, Kan; Sato, Nobuhiro (2025). "Antibiotic combination therapy for the induction and maintenance of remission in patients with ulcerative colitis". Bioscience of Microbiota, Food and Health. 44 (4): 272–278. doi:10.12938/bmfh.2025-015. PMC   12490872 . PMID   41050156.
  36. ↑ Koido, Shigeo; Ohkusa, Toshifumi; Kajiura, Takayuki; Shinozaki, Junko; Suzuki, Manabu; Saito, Keisuke; Takakura, Kazuki; Tsukinaga, Shintaro; Odahara, Shunichi; Yukawa, Toyokazu; Mitobe, Jimi; Kajihara, Mikio; Uchiyama, Kan; Arakawa, Hiroshi; Tajiri, Hisao (2014). "Long-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapy". PLOS ONE. 9 (1) e86702. Bibcode:2014PLoSO...986702K. doi: 10.1371/journal.pone.0086702 . ISSN   1932-6203. PMC   3906066 . PMID   24489770.
  37. ↑ Ohkusa, Toshifumi; Koido, Shigeo; Nishikawa, Yuriko; Sato, Nobuhiro (2019). "Gut Microbiota and Chronic Constipation: A Review and Update". Frontiers in Medicine. 6 19. doi: 10.3389/fmed.2019.00019 . ISSN   2296-858X. PMC   6379309 . PMID   30809523.
  38. ↑ Nishikawa, Yuriko; Sato, Nobuhiro; Tsukinaga, Shintaro; Uchiyama, Kan; Koido, Shigeo; Ishikawa, Dai; Ohkusa, Toshifumi (2021). "Long-term outcomes of antibiotic combination therapy for ulcerative colitis". Therapeutic Advances in Chronic Disease. 12 20406223211028790. doi:10.1177/20406223211028790. ISSN   2040-6223. PMC   8264727 . PMID   34285790.
  39. ↑ Ohkusa, Toshifumi; Koido, Shigeo; Horiuchi, Sankichi; Kan, Shin; Ito, Zensho; Nishikawa, Yuriko; Sato, Nobuhiro (2022). "Growth of various obligate and facultative anaerobic intestinal bacteria in cell culture medium under aerobic and anaerobic culture conditions". Bioscience of Microbiota, Food and Health. 41 (3): 145–148. doi:10.12938/bmfh.2021-065. ISSN   2186-6953. PMC   9246421 . PMID   35854697.
  40. ↑ Ohkusa, Toshifumi; Nishikawa, Yuriko; Sato, Nobuhiro (2022). "Gastrointestinal disorders and intestinal bacteria: Advances in research and applications in therapy". Frontiers in Medicine. 9 935676. doi: 10.3389/fmed.2022.935676 . ISSN   2296-858X. PMC   9941163 . PMID   36825261.
  41. ↑ Ohkusa, Toshifumi; Kato, Kimitoshi; Sekizuka, Tsuyoshi; Sugiyama, Toshiro; Sato, Nobuhiro; Kuroda, Makoto (16 October 2024). "Comparison of the Gut Microbiota of Patients Who Improve with Antibiotic Combination Therapy for Ulcerative Colitis and Those Who Do Not: Investigation by Fecal Metagenomic Analyses". Nutrients. 16 (20): 3500. doi: 10.3390/nu16203500 . ISSN   2072-6643. PMC   11510665 . PMID   39458495.
  42. ↑ Koido, Shigeo; Homma, Sadamu; Kan, Shin; Takakura, Kazuki; Namiki, Yoshihisa; Kobayashi, Hiroko; Ito, Zensho; Uchiyama, Kan; Kajihara, Mikio; Arihiro, Seiji; Arakawa, Hiroshi; Okamoto, Masato; Ohkusa, Toshifumi; Gong, Jianlin; Tajiri, Hisao (July 2014). "Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells". International Journal of Oncology. 45 (1): 470–478. doi:10.3892/ijo.2014.2433. ISSN   1791-2423. PMID   24819411.
  43. ↑ Koido, Shigeo; Ohkusa, Toshifumi; Nakae, Kosaburo; Yokoyama, Tetsuji; Shibuya, Tomoyoshi; Sakamoto, Naoto; Uchiyama, Kan; Arakawa, Hiroshi; Osada, Taro; Nagahara, Akihito; Watanabe, Sumio; Tajiri, Hisao (14 June 2014). "Factors associated with incomplete colonoscopy at a Japanese academic hospital". World Journal of Gastroenterology. 20 (22): 6961–6967. doi: 10.3748/wjg.v20.i22.6961 . ISSN   2219-2840. PMC   4051938 . PMID   24944489.
  44. ↑ Koido, Shigeo; Homma, Sadamu; Okamoto, Masato; Takakura, Kazuki; Mori, Masako; Yoshizaki, Shinji; Tsukinaga, Shintaro; Odahara, Shunichi; Koyama, Seita; Imazu, Hiroo; Uchiyama, Kan; Kajihara, Mikio; Arakawa, Hiroshi; Misawa, Takeyuki; Toyama, Yoichi; Yanagisawa, Satoru; Ikegami, Masahiro; Kan, Shin; Hayashi, Kazumi; Komita, Hideo; Kamata, Yuko; Ito, Masaki; Ishidao, Takefumi; Yusa, Sei-Ichi; Shimodaira, Shigetaka; Gong, Jianlin; Sugiyama, Haruo; Ohkusa, Toshifumi; Tajiri, Hisao (15 August 2014). "Treatment with chemotherapy and dendritic cells pulsed with multiple Wilms' tumor 1 (WT1)-specific MHC class I/II-restricted epitopes for pancreatic cancer". Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. 20 (16): 4228–4239. doi:10.1158/1078-0432.CCR-14-0314. ISSN   1557-3265. PMID   25056373.
  45. ↑ Koido, Shigeo; Homma, Sadamu; Okamoto, Masato; Takakura, Kazuki; Gong, Jianlin; Sugiyama, Haruo; Ohkusa, Toshifumi; Tajiri, Hisao (November 2014). "Chemoimmunotherapy targeting Wilms' tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer". Oncoimmunology. 3 (10) e958950. doi:10.4161/21624011.2014.958950. ISSN   2162-4011. PMC   4292571 . PMID   25941581.
  46. ↑ Kajihara, Mikio; Takakura, Kazuki; Kanai, Tomoya; Ito, Zensho; Saito, Keisuke; Takami, Shinichiro; Shimodaira, Shigetaka; Okamoto, Masato; Ohkusa, Toshifumi; Koido, Shigeo (7 May 2016). "Dendritic cell-based cancer immunotherapy for colorectal cancer". World Journal of Gastroenterology. 22 (17): 4275–4286. doi: 10.3748/wjg.v22.i17.4275 . ISSN   2219-2840. PMC   4853685 . PMID   27158196.
  47. ↑ Kajihara, Mikio; Takakura, Kazuki; Kanai, Tomoya; Ito, Zensho; Matsumoto, Yoshihiro; Shimodaira, Shigetaka; Okamoto, Masato; Ohkusa, Toshifumi; Koido, Shigeo (14 May 2016). "Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer". World Journal of Gastroenterology. 22 (18): 4446–4458. doi: 10.3748/wjg.v22.i18.4446 . ISSN   2219-2840. PMC   4858628 . PMID   27182156.
  48. ↑ Miyauchi, Eiji; Taida, Takashi; Kawasumi, Masami; Ohkusa, Toshifumi; Sato, Nobuhiro; Ohno, Hiroshi (2 February 2022). "Analysis of colonic mucosa-associated microbiota using endoscopically collected lavage". Scientific Reports. 12 (1): 1758. Bibcode:2022NatSR..12.1758M. doi:10.1038/s41598-022-05936-y. ISSN   2045-2322. PMC   8810796 . PMID   35110685.
  49. ↑ Asaoka, Daisuke; Xiao, Jinzhong; Takeda, Tsutomu; Yanagisawa, Naotake; Yamazaki, Takahiro; Matsubara, Yoichiro; Sugiyama, Hideki; Endo, Noemi; Higa, Motoyuki; Kasanuki, Koji; Ichimiya, Yosuke; Koido, Shigeo; Ohno, Kazuya; Bernier, Francois; Katsumata, Noriko; Nagahara, Akihito; Arai, Heii; Ohkusa, Toshifumi; Sato, Nobuhiro (2022). "Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial". Journal of Alzheimer's Disease: JAD. 88 (1): 75–95. doi:10.3233/JAD-220148. ISSN   1875-8908. PMC   9277669 . PMID   35570493.
  50. ↑ Ito, Zensho; Koido, Shigeo; Kato, Kumiko; Odamaki, Toshitaka; Horiuchi, Sankichi; Akasu, Takafumi; Saruta, Masayuki; Hata, Taigo; Kumagai, Yu; Fujioka, Shuichi; Misawa, Takeyuki; Xiao, Jin-Zhong; Sato, Nobuhiro; Ohkusa, Toshifumi (31 October 2022). "Dysbiosis of the Fecal and Biliary Microbiota in Biliary Tract Cancer". Cancers. 14 (21): 5379. doi: 10.3390/cancers14215379 . ISSN   2072-6694. PMC   9653963 . PMID   36358797.
  51. ↑ Ito, Eisaku; Ohki, Takao; Toya, Naoki; Nakagawa, Hikaru; Horigome, Ayako; Odamaki, Toshitaka; Xiao, Jin-Zhong; Koido, Shigeo; Nishikawa, Yuriko; Ohkusa, Toshifumi; Sato, Nobuhiro (2023). "Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study". Bioscience of Microbiota, Food and Health. 42 (1): 81–86. doi:10.12938/bmfh.2022-055. ISSN   2186-6953. PMC   9816055 . PMID   36660598.
  52. ↑ Koido, Shigeo; Taguchi, Junichi; Shimabuku, Masamori; Kan, Shin; Bito, Tuuse; Misawa, Takeyuki; Ito, Zensho; Uchiyama, Kan; Saruta, Masayuki; Tsukinaga, Shintaro; Suka, Machi; Yanagisawa, Hiroyuki; Sato, Nobuhiro; Ohkusa, Toshifumi; Shimodaira, Shigetaka; Sugiyama, Haruo (8 October 2024). "Dendritic cells pulsed with multifunctional Wilms' tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in pancreatic cancer". Journal for Immunotherapy of Cancer. 12 (10) e009765. doi:10.1136/jitc-2024-009765. ISSN   2051-1426. PMC   11474828 . PMID   39384197.
  53. ↑ Koido, Shigeo; Taguchi, Junichi; Shimabuku, Masamori; Kan, Shin; Bito, Tuuse; Misawa, Takeyuki; Ito, Zensho; Uchiyama, Kan; Saruta, Masayuki; Tsukinaga, Shintaro; Suka, Machi; Yanagisawa, Hiroyuki; Sato, Nobuhiro; Ohkusa, Toshifumi; Shimodaira, Shigetaka; Sugiyama, Haruo (8 October 2024). "Dendritic cells pulsed with multifunctional Wilms' tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in pancreatic cancer". Journal for Immunotherapy of Cancer. 12 (10) e009765. doi:10.1136/jitc-2024-009765. ISSN   2051-1426. PMC   11474828 . PMID   39384197.
  54. ↑ Koido, Shigeo; Taguchi, Junichi; Shimabuku, Masamori; Bito, Tuuse; Morimoto, Soyoko; Oji, Yusuke; Oka, Yoshihiro; Ito, Masaki; Shimizu, Yoko; Ito, Zensho; Uchiyama, Kan; Saruta, Masayuki; Sato, Nobuhiro; Ohkusa, Toshifumi; Shimodaira, Shigetaka; Sugiyama, Haruo (31 July 2025). "Predictors of patients with advanced pancreatic cancer undergoing conversion surgery via chemoimmunotherapy with a multifunctional Wilms' tumor 1 (WT1) peptide cocktail-pulsed dendritic cell vaccine". Journal for Immunotherapy of Cancer. 13 (7) e011426. doi:10.1136/jitc-2024-011426. ISSN   2051-1426. PMC   12314961 . PMID   40744662.
  55. ↑ Asaoka, Daisuke; Toda, Kazuya; Yoshimoto, Shin; Katsumata, Noriko; Odamaki, Toshitaka; Iwabuchi, Noriyuki; Tanaka, Miyuki; Xiao, Jin-Zhong; Nishikawa, Yuriko; Nomura, Osamu; Takeda, Tsutomu; Nagahara, Akihito; Koido, Shigeo; Ohkusa, Toshifumi; Sato, Nobuhiro (21 May 2025). "Sex-Specific Associations of Gut Microbiota Composition with Sarcopenia Defined by the Asian Working Group for Sarcopenia 2019 Consensus in Older Outpatients: Prospective Cross-Sectional Study in Japan". Nutrients. 17 (10): 1746. doi: 10.3390/nu17101746 . ISSN   2072-6643. PMC   12114429 . PMID   40431485.
  56. ↑ Nishikawa, Yuriko; Xu, Chendong; Yoshimoto, Shin; Katsumata, Noriko; Iwabuchi, Noriyuki; Yanagisawa, Naotake; Koido, Shigeo; Tanaka, Miyuki; Xiao, Jin-Zhong; Asaoka, Daisuke; Ohkusa, Toshifumi; Sato, Nobuhiro (17 September 2025). "Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study". Nutrients. 17 (18): 2976. doi: 10.3390/nu17182976 . PMC   12472256 . PMID   41010502.
Toshifumi Ohkusa
Occupation(s) Academic and an author
Academic background
Education M.D.
Ph.D.
Alma mater Tokyo Medical and Dental University
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