Troxacitabine

Troxacitabine
Identifiers
	IUPAC name 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2(1H)-one;
CAS Number	145918-75-8 ;
PubChem CID	151173 ;
ChemSpider	399955 ;
UNII	60KQZ0388Y ;
ChEMBL	ChEMBL359164 ;
CompTox Dashboard (EPA)	DTXSID2048791 ;
Chemical and physical data
Formula	C8H11N3O4
Molar mass	213.193 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C1/N=C(/N)\C=C/N1[C@H]2O[C@H](OC2)CO;
	InChI InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1 ; Key:RXRGZNYSEHTMHC-BQBZGAKWSA-N ;
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Last updated June 30, 2025

Troxacitabine (brand name Troxatyl) is a nucleoside analogue with anticancer activity. Its use is being studied in patients with refractory lymphoproliferative diseases.^[1]

References

↑ Vose JM, Panwalkar A, Belanger R, Coiffier B, Baccarani M, Gregory SA, et al. (January 2007). "A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma". Leukemia & Lymphoma. 48 (1): 39–45. doi:10.1080/10428190600909578. PMID 17325846. S2CID 36220728.

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[1] Vose JM, Panwalkar A, Belanger R, Coiffier B, Baccarani M, Gregory SA, et al. (January 2007). "A phase II multicenter study of troxacitabine in relapsed or refractory lymphoproliferative neoplasms or multiple myeloma". Leukemia & Lymphoma. 48 (1): 39–45. doi:10.1080/10428190600909578. PMID 17325846. S2CID 36220728.

[1]

Identifiers

IUPAC name 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2(1H)-one
CAS Number	145918-75-8 ^N
PubChem CID	151173
ChemSpider	399955 ^Y
UNII	60KQZ0388Y
ChEMBL	ChEMBL359164 ^Y
CompTox Dashboard (EPA)	DTXSID2048791
Chemical and physical data
Formula	C₈H₁₁N₃O₄
Molar mass	213.193 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1/N=C(/N)\C=C/N1[C@H]2O[C@H](OC2)CO
InChI InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1^Y Key:RXRGZNYSEHTMHC-BQBZGAKWSA-N^Y
^NY (what is this?) (verify)