U.S. Route 45 is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,297 miles (2,087 km).
U.S. Route 62 or U.S. Highway 62 (US 62) is an east–west United States Highway in the southern and northeastern United States. It runs from the Mexican border at El Paso, Texas, to Niagara Falls, New York, near the Canadian border. It is the only east–west United States Numbered Highway that connects Mexico and Canada. Parts of US 62 follow what once was the Ozark Trail, including the historic bridge across the South Canadian River in Newcastle, Oklahoma. This bridge was damaged beyond repair by the 2013 Moore tornado that struck Newcastle and Moore, Oklahoma. The highway runs north–south in New York and Pennsylvania.
U.S. Route 51 or U.S. Highway 51 is a major south–north United States highway that extends 1,277 miles (2,055 km) from the western suburbs of New Orleans, Louisiana, to within 150 feet (46 m) of the Wisconsin–Michigan state line. As most of the United States Numbered Highways ending with "1", it is a cross-country north–south route extending from the Gulf Coast region to the Great Lakes region. Much of the highway in northern Illinois and southern Wisconsin runs parallel to or is cosigned with Interstate 39 (I-39) and much of the route in several states also parallels the Illinois Central Railroad. From LaPlace, Louisiana, Mississippi, to Memphis, Tennessee, much of that portion of US 51 runs largely parallel or is concurrent with Interstate 55 (I-55). The highway's northern terminus is between Hurley, Wisconsin, and Ironwood, Michigan, where it ends with a roundabout at US 2. Its southern terminus is in Laplace, Louisiana, ending at US 61. US 51 is routed through the states of Louisiana, Mississippi, Tennessee, Kentucky, Illinois, and Wisconsin.
Kentucky Route 55 is a 140.858-mile-long (226.689 km) state highway in the U.S. Commonwealth of Kentucky.
Kentucky Route 80 (KY 80) is a 483.55-mile-long (778.20 km) state highway in the southern part of the U.S. state of Kentucky. The route originates on the state's western border at Columbus in Hickman County and stretches across the southern portion of the state, terminating southeast of Elkhorn City on the Virginia state line. It is the longest Kentucky State Highway, though the official distance as listed in route logs is much less due to multiple concurrencies with U.S. Route 68 (US 68) and US 23.
The Julian M. Carroll Purchase Parkway is a freeway in the US state of Kentucky running from Fulton to Mayfield, near Kentucky Dam, for a length of 21 miles (34 km). It begins at the Tennessee state line concurrent with U.S. Route 51 only a few yards from an intersection with US 45W, US 45E, and US 45 at its southern terminus, and at I-69 just prior to reaching the US 45 Bypass exit in Mayfield at its northern terminus. It is one of seven highways that are part of the Kentucky Parkway System. The parkway previously extended north from Mayfield to I-24 near Calvert City. However, in July 2018, this segment was replaced by an extension of I-69. The rest of the parkway south to the Tennessee border remains Future Interstate 69.
U.S. Route 31W is the westernmost of two parallel routes for U.S. Route 31 from Nashville, Tennessee to Louisville, Kentucky.
Interstate 69 (I-69) in the US state of Kentucky is a 148.1-mile-long (238.3 km) freeway running from Fulton to Henderson. The route makes use of most of the Purchase Parkway and existing portions of I-24, the Western Kentucky Parkway, and the Pennyrile Parkway. Eventually, I-69 will leave the former Pennyrile Parkway just south of the Audubon Parkway interchange or remain on its current alignment and travel through Henderson on U.S. Route 41 (US 41) north into Indiana. The proposed route for the remainder of I-69 in Kentucky travels about 10 miles (16 km) to utilize an as-of-yet-unbuilt bridge into Indiana.
U.S. Route 62 (US 62) in Kentucky runs for a total of 391.207 miles (629.587 km) across 20 counties in western, north-central, and northeastern Kentucky. It enters the state by crossing the Ohio River near Wickliffe, then begins heading eastward at Bardwell, and traversing several cities and towns across the state up to Maysville, where it crosses the Ohio River a second time to enter the state of Ohio.
Kentucky Route 239 (KY 239) is a 10.3-mile-long (16.6 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of Fulton and Hickman counties with the Tennessee state line.
Kentucky Route 284 (KY 284) is a 6.8-mile-long (10.9 km) state highway in the U.S. state of Kentucky. The highway connects Paducah, Woodlawn-Oakdale, and Reidland, within McCracken County.
Kentucky Route 303 (KY 303) is a 16.9-mile-long (27.2 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of Graves County with the Tennessee state line and Mayfield.
Kentucky Route 305 (KY 305) is a 14.3-mile-long (23.0 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of McCracken County with West Paducah and Paducah.
Kentucky Route 307 (KY 307) is a 28.3-mile-long (45.5 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of Fulton, Hickman, and Carlisle counties with Fulton.
Kentucky Route 339 (KY 339) is a 45.513-mile-long (73.246 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of Graves and McCracken counties with Wingo, Massac, and Hendron.
Kentucky Route 348 (KY 348) is a 20.566-mile-long (33.098 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of McCracken, Graves, and Marshall counties with Symsonia and Benton.
Kentucky Route 358 (KY 358) is a 29.590-mile-long (47.620 km) state highway in the U.S. state of Kentucky. The highway connects mostly rural areas of Ballard and McCracken counties with LaCenter.
US 45 / SR 3 at Tennessee state line in Fulton 
