UBASH3A

UBASH3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRN
Identifiers
Aliases	UBASH3A , CLIP4, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A
External IDs	OMIM: 605736 MGI: 1926074 HomoloGene: 56833 GeneCards: UBASH3A
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,447,684 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,465,866 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; thymus; ; spleen; ; bone marrow; ; urinary bladder; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding ; phosphatase activity ;
Cellular component	cytoplasm ; cytosol ; extracellular exosome ; nucleus ; nucleoplasm ; Golgi apparatus ;
Biological process	regulation of cytokine production ; negative regulation of T cell receptor signaling pathway ; negative regulation of signal transduction ; dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	53347
	328795
	ENSG00000160185
	ENSMUSG00000042345
	P57075
	Q3V3E1
	NM_001001895 ; NM_001243467 ; NM_018961
	NM_177823
	NP_001001895 ; NP_001230396 ; NP_061834
	NP_808491
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 08, 2022

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.^[5]^[6]

Related Research Articles

Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes. This protein has been linked to X-linked spinal muscular atrophy type 2, neurodegenerative diseases, and cancers.

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Baculoviral IAP repeat-containing protein3 is a protein that in humans is encoded by the BIRC3 gene.

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene. PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis .[supplied by OMIM]

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.

Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160185 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042345 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.
↑ "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion". Virology. 372 (1): 10–23. doi: 10.1016/j.virol.2007.10.012 . PMID 18006034.
Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis". J. Biol. Chem. 282 (42): 30920–8. doi: 10.1074/jbc.M706870200 . PMID 17709377.
Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. hdl: 10852/28097 . PMID 17382318.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728 . PMID 16780588.
Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi: 10.1074/jbc.M403759200 . PMID 15159412.
Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin". Oncogene. 23 (27): 4690–706. doi: 10.1038/sj.onc.1207627 . PMID 15107835.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160185 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042345 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11281453-5] Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet. 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453. S2CID 22719211.

[entrez-6] "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

[1]

[2]

[3]

[4]

[5]

[6]

UBASH3A

Related Research Articles

References

Further reading