UBE1L2

UBA6
Identifiers
Aliases	UBA6 , E1-L2, MOP-4, UBE1L2, ubiquitin like modifier activating enzyme 6
External IDs	OMIM: 611361 MGI: 1913894 HomoloGene: 10080 GeneCards: UBA6
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q13.2 Start 67,612,652 bp [1] End 67,701,155 bp [1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • FAT10 activating enzyme activity • nucleotide binding • ligase activity • GO:0001948 protein binding • ATP binding • ubiquitin-like modifier activating enzyme activity • ubiquitin activating enzyme activity Cellular component • cytosol • cytoplasm Biological process • dendritic spine development • cellular protein modification process • amygdala development • learning • hippocampus development • ubiquitin-dependent protein catabolic process • locomotory behavior • protein ubiquitination • cellular response to DNA damage stimulus • protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55236	231380
Ensembl	ENSG00000033178	ENSMUSG00000035898
UniProt	A0AVT1 H0Y9U5	Q8C7R4
RefSeq (mRNA)	NM_018227	NM_172712
RefSeq (protein)	NP_060697	NP_766300
Location (UCSC)	Chr 4: 67.61 – 67.7 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene. ^{[4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000033178 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M (Aug 2007). "UBE1L2, a novel E1 enzyme specific for ubiquitin". J Biol Chem. 282 (32): 23010–4. doi: 10.1074/jbc.C700111200 . PMID   17580310.
5. "Entrez Gene: UBE1L2 ubiquitin-activating enzyme E1-like 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zhu H, Zhou ZM, Huo R, et al. (2004). "Identification and characteristics of a novel E1 like gene nUBE1L in human testis". Acta Biochim. Biophys. Sin. (Shanghai). 36 (3): 227–34. doi:10.1093/abbs/36.3.227. PMID   15202508.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi: 10.1038/nature03466 . PMID   15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Jin J, Li X, Gygi SP, Harper JW (2007). "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging". Nature. 447 (7148): 1135–8. doi:10.1038/nature05902. PMID   17597759. S2CID   4337767.
• Chiu YH, Sun Q, Chen ZJ (2007). "E1-L2 activates both ubiquitin and FAT10". Mol. Cell. 27 (6): 1014–23. doi:10.1016/j.molcel.2007.08.020. PMID   17889673.