UBE3C

UBE3C
Identifiers
Aliases	UBE3C , HECTH2, ubiquitin protein ligase E3C, RAUL
External IDs	OMIM: 614454 MGI: 2140998 HomoloGene: 8783 GeneCards: UBE3C
Gene location (Human)
Chr.	Chromosome 7 (human)
End	157,269,370 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	29,881,090 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; islet of Langerhans; ; gastrocnemius muscle; ; stromal cell of endometrium; ; rectum; ; thymus; ; monocyte; ; smooth muscle tissue; ; bone marrow cells;
	Top expressed in
	spermatocyte; ; spermatid; ; facial motor nucleus; ; triceps brachii muscle; ; cumulus cell; ; trigeminal ganglion; ; superior frontal gyrus; ; primitive streak; ; secondary oocyte; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; ubiquitin-protein transferase activity ; transferase activity ; ubiquitin protein ligase activity ; ubiquitin conjugating enzyme activity ;
Cellular component	proteasome complex ; intracellular anatomical structure ; nucleus ; cytoplasm ;
Biological process	protein polyubiquitination ; protein ubiquitination ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	9690
	100763
	ENSG00000009335
	ENSMUSG00000039000
	Q15386
	Q80U95
	NM_014671
	NM_133907
	NP_055486
	NP_598668
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000009335 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039000 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID 7584026.
↑ You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi: 10.1074/jbc.M100034200 . PMID 11278995.
↑ "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
You J, Wang M, Aoki T, et al. (2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369–75. doi: 10.1074/jbc.M212887200 . PMID 12692129.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID 7584028.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000009335 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039000 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7584026-5] Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID 7584026.

[pmid11278995-6] You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi: 10.1074/jbc.M100034200 . PMID 11278995.

[entrez-7] "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

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UBE3C

Related Research Articles

References

Further reading