UBE3C

UBE3C
Identifiers
Aliases	UBE3C , HECTH2, ubiquitin protein ligase E3C, RAUL
External IDs	OMIM: 614454; MGI: 2140998; HomoloGene: 8783; GeneCards: UBE3C; OMA:UBE3C - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q36.3 Start 157,138,916 bp [1] End 157,269,370 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 29,774,240 bp [2] End 29,881,090 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon islet of Langerhans epithelium of colon gastrocnemius muscle muscle of thigh stromal cell of endometrium gingival epithelium Skeletal muscle tissue of biceps brachii rectum Top expressed in spermatocyte muscle of thigh spermatid dentate gyrus of hippocampal formation granule cell tail of embryo facial motor nucleus triceps brachii muscle cumulus cell trigeminal ganglion primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity ubiquitin conjugating enzyme activity Cellular component proteasome complex intracellular anatomical structure nucleus cytoplasm Biological process protein polyubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9690 100763 Ensembl ENSG00000009335 ENSMUSG00000039000 UniProt Q15386 Q80U95 RefSeq (mRNA) NM_014671 NM_133907 RefSeq (protein) NP_055486 NP_598668 Location (UCSC) Chr 7: 157.14 – 157.27 Mb Chr 5: 29.77 – 29.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000009335 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039000 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
6. You J, Pickart CM (Jun 2001). "A HECT domain E3 enzyme assembles novel polyubiquitin chains". J Biol Chem. 276 (23): 19871–8. doi: 10.1074/jbc.M100034200 . PMID   11278995.
7. "Entrez Gene: UBE3C ubiquitin protein ligase E3C".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• You J, Wang M, Aoki T, et al. (2003). "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase". J. Biol. Chem. 278 (26): 23369–75. doi: 10.1074/jbc.M212887200 . PMID   12692129.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.