UBP1

UBP1
Identifiers
Aliases	UBP1 , LBP-1B, LBP-1a, LBP1A, LBP1B, upstream binding protein 1 (LBP-1a), upstream binding protein 1
External IDs	OMIM: 609784; MGI: 104889; HomoloGene: 8435; GeneCards: UBP1; OMA:UBP1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p22.3 Start 33,388,336 bp [1] End 33,441,371 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F3 Start 113,760,002 bp [2] End 113,806,270 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia rectum sural nerve visceral pleura popliteal artery tibial arteries appendix right coronary artery smooth muscle tissue endothelial cell Top expressed in Paneth cell medullary collecting duct secondary oocyte tibiofemoral joint primary oocyte zygote ureter renal corpuscle saccule otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process viral genome replication negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated angiogenesis transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7342 22221 Ensembl ENSG00000153560 ENSMUSG00000009741 UniProt Q9NZI7 Q811S7 RefSeq (mRNA) NM_001128160 NM_001128161 NM_014517 NM_001083319 NM_013699 NM_001372507 NM_001372508 NM_001372510 NM_001372511 NM_001372512 NM_001372514 RefSeq (protein) NP_001121632 NP_001121633 NP_055332 NP_001076788 NP_038727 NP_001359436 NP_001359437 NP_001359439 NP_001359440 NP_001359441 NP_001359443 Location (UCSC) Chr 3: 33.39 – 33.44 Mb Chr 9: 113.76 – 113.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000153560 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009741 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Mol Cell Biol. 14 (3): 1776–85. doi:10.1128/mcb.14.3.1776. PMC   358535 . PMID   8114710.
6. "Entrez Gene: UBP1 upstream binding protein 1 (LBP-1a)".

Further reading

• Kato H, Horikoshi M, Roeder RG (1991). "Repression of HIV-1 transcription by a cellular protein". Science. 251 (5000): 1476–9. Bibcode:1991Sci...251.1476K. doi:10.1126/science.2006421. PMID   2006421.
• Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. doi: 10.1074/jbc.270.5.2274 . PMID   7836461.
• Huang N, Miller WL (2000). "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc". J. Biol. Chem. 275 (4): 2852–8. doi: 10.1074/jbc.275.4.2852 . PMID   10644752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zhao H, Li J, Jiang L (2004). "Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)". Biochem. Biophys. Res. Commun. 320 (1): 95–9. doi:10.1016/j.bbrc.2004.05.148. PMID   15207707.
• Huang N, Miller WL (2005). "LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells". Mol. Endocrinol. 19 (2): 409–20. doi: 10.1210/me.2004-0086 . PMID   15471945.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.