UBR4

For the uranium compound, see Uranium tetrabromide.

UBR4
Identifiers
Aliases	UBR4 , RBAF600, ZUBR1, p600, ubiquitin protein ligase E3 component n-recognin 4
External IDs	OMIM: 609890; MGI: 1916366; HomoloGene: 10804; GeneCards: UBR4; OMA:UBR4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.13 Start 19,074,510 bp [1] End 19,210,266 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D3 Start 139,079,920 bp [2] End 139,216,899 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen right testis left testis gastric mucosa anterior pituitary stromal cell of endometrium apex of heart right lung left ovary Top expressed in entorhinal cortex perirhinal cortex lactiferous gland CA3 field muscle of thigh neural layer of retina dentate gyrus of hippocampal formation granule cell superior frontal gyrus ventricular zone choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding calmodulin binding ubiquitin-protein transferase activity transferase activity Cellular component integral component of membrane centrosome cytoskeleton membrane nucleus nucleoplasm cytoplasm cytosol plasma membrane specific granule membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process viral process protein ubiquitination neutrophil degranulation ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23352 69116 Ensembl ENSG00000127481 ENSMUSG00000066036 UniProt Q5T4S7 A2AN08 RefSeq (mRNA) NM_020765 NM_001160319 RefSeq (protein) NP_065816 NP_001153791 Location (UCSC) Chr 1: 19.07 – 19.21 Mb Chr 4: 139.08 – 139.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase UBR4 is an enzyme that in humans is encoded by the UBR4 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000127481 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066036 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (Dec 2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
6. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
7. Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons". Mol Cell Biol. 25 (16): 7120–7136. doi:10.1128/MCB.25.16.7120-7136.2005. PMC   1190250 . PMID   16055722.
8. "Entrez Gene: ZUBR1 zinc finger, UBR1 type 1".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–349. doi: 10.1093/dnares/4.5.345 . PMID   9455484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Huh KW, DeMasi J, Ogawa H, et al. (2005). "Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11492–11497. Bibcode:2005PNAS..10211492H. doi: 10.1073/pnas.0505337102 . PMC   1182135 . PMID   16061792.
• Nakatani Y, Konishi H, Vassilev A, et al. (2005). "p600, a unique protein required for membrane morphogenesis and cell survival". Proc. Natl. Acad. Sci. U.S.A. 102 (42): 15093–15098. doi: 10.1073/pnas.0507458102 . PMC   1247991 . PMID   16214886.
• Lennerz V, Fatho M, Gentilini C, et al. (2005). "The response of autologous T cells to a human melanoma is dominated by mutated neoantigens". Proc. Natl. Acad. Sci. U.S.A. 102 (44): 16013–16018. Bibcode:2005PNAS..10216013L. doi: 10.1073/pnas.0500090102 . PMC   1266037 . PMID   16247014.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.