UHRF2

UHRF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WY8, 1Z6U, 2E6S, 3OLN, 4PW5, 4PW6, 4PW7, 4TVR
Identifiers
Aliases	UHRF2 , NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDs	OMIM: 615211 MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	6,507,054 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	30,071,122 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pancreatic epithelial cell; ; Achilles tendon; ; tibia; ; thymus; ; sperm; ; germinal epithelium; ; bone marrow; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	superior cervical ganglion; ; hand; ; primitive streak; ; lens; ; thymus; ; otolith organ; ; utricle; ; ganglionic eminence; ; dermis; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; histone binding ; protein binding ; metal ion binding ; ubiquitin protein ligase activity ; ubiquitin-protein transferase activity ; transferase activity ; SUMO transferase activity ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	protein autoubiquitination ; regulation of DNA methylation-dependent heterochromatin assembly ; cell cycle ; cell differentiation ; cell population proliferation ; maintenance of DNA methylation ; protein ubiquitination ; regulation of cell cycle ; protein sumoylation ;
	Sources:Amigo / QuickGO
Orthologs
	115426
	109113
	ENSG00000147854
	ENSMUSG00000024817
	Q96PU4
	Q7TMI3
	NM_152896 ; NM_152306
	NM_144873
	NP_690856
	NP_659122
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 15, 2024

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.^[5]^[6]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000147854 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024817 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
1 2 "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834. S2CID 21948278.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369. S2CID 10006213.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000147854 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024817 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12176013-5] Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.

[entrez-6] 1 2 "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".

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UHRF2

Related Research Articles

References

Further reading