UNC5A

UNC5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V2A
Identifiers
Aliases	UNC5A , UNC5H1, unc-5 netrin receptor A
External IDs	OMIM: 607869 MGI: 894682 HomoloGene: 41474 GeneCards: UNC5A
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,880,898 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,153,831 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; postcentral gyrus; ; cingulate gyrus; ; ganglionic eminence; ; entorhinal cortex;
	Top expressed in
	secondary oocyte; ; superior frontal gyrus; ; hippocampus proper; ; humerus; ; Anterior olfactory nucleus; ; cerebellar cortex; ; Meckel's cartilage; ; lateral part of occipital bone; ; rib; ; lesser wing of sphenoid bone;
	More reference expression data
	n/a
Gene ontology
Molecular function	netrin receptor activity ;
Cellular component	intrinsic component of plasma membrane ; integral component of membrane ; neuronal cell body membrane ; membrane raft ; plasma membrane ; cell projection ; neuron projection membrane ; membrane ;
Biological process	multicellular organism development ; neuron projection development ; signal transduction ; anterior/posterior axon guidance ; axon guidance ; apoptotic process ; netrin-activated signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	90249
	107448
	ENSG00000113763
	ENSMUSG00000025876
	Q6ZN44
	Q8K1S4
	NM_133369
	NM_153131 ; NM_001311128
	NP_588610
	NP_001298057 ; NP_694771
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[5]

Interactions

UNC5A has been shown to interact with MAGED1.^[6]

Related Research Articles

Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word "netr", which means "one who guides". Netrins are genetically conserved across nematode worms, fruit flies, frogs, mice, and humans. Structurally, netrin resembles the extracellular matrix protein laminin.

Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer and its previous name was Deleted in colorectal carcinoma. Netrin receptor DCC is a single transmembrane receptor.

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin involved in apoptosis and cytokine release. It is a member of the tumor necrosis factor receptor superfamily.

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).

Baculoviral IAP repeat-containing protein 2 is a protein that in humans is encoded by the BIRC2 gene.

SH3 domain-containing kinase-binding protein 1 is an adaptor protein that in humans is encoded by the SH3KBP1 gene.

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3.

Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.

CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.

Neogenin is a protein that in humans is encoded by the NEO1 gene.

RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.

UNC is a set of proteins first identified through a set of screening tests in Caenorhabditis elegans, looking for roundworms with movement problems. Worms with which were un-coordinated were analysed in order to identify the genetic defect. Such proteins include UNC-5, a receptor for UNC-6 which is one of the netrins. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion (genetics) to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.

UNC-5 is a receptor for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.

Patrick Mehlen, is a French biologist and research director at the Centre national de recherche scientifique (CNRS) at the Centre Léon-Bérard, a cancer research centre in Lyon.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113763 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025876 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
↑ Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi: 10.1074/jbc.M300415200 . PMID 12598531.

Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119. S2CID 867903.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi: 10.1074/jbc.M300415200 . PMID 12598531.
Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906. S2CID 7017409.
Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi: 10.1073/pnas.0738063100 . PMC 153067 . PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry. 278 (35): 32561–8. doi: 10.1074/jbc.M302943200 . PMID 12810718.
Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396 . PMID 15729359.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113763 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025876 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".

[pmid12598531-6] Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi: 10.1074/jbc.M300415200 . PMID 12598531.

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UNC5A

Contents

Interactions

Related Research Articles

References

Further reading