UNC5C

UNC5C
Identifiers
Aliases	UNC5C , UNC5H3, unc-5 netrin receptor C
External IDs	OMIM: 603610 MGI: 1095412 HomoloGene: 2765 GeneCards: UNC5C
Gene location (Human)
Chr.	Chromosome 4 (human)
End	95,549,206 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	141,540,685 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; tibia; ; internal globus pallidus; ; pons; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; right coronary artery; ; Superior vestibular nucleus; ; thyroid gland; ; left coronary artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	netrin receptor activity ; netrin receptor activity involved in chemorepulsion ; GO:0001948 protein binding ; protein kinase binding ; tubulin binding ;
Cellular component	integral component of membrane ; neuron projection ; cell junction ; plasma membrane ; synapse ; membrane ; axon ; dendrite ; growth cone ; neuronal cell body ; lamellipodium ; filopodium ; cell surface ; cell projection ;
Biological process	positive regulation of apoptotic process ; netrin-activated signaling pathway ; multicellular organism development ; brain development ; regulation of cell migration ; signal transduction ; anterior/posterior axon guidance ; axon guidance ; apoptotic process ; negative chemotaxis ; chemorepulsion of axon ; dorsal root ganglion development ;
	Sources:Amigo / QuickGO
Orthologs
	8633
	22253
	ENSG00000182168
	ENSMUSG00000059921
	O95185
	O08747
	NM_003728
	NM_001293561 ; NM_009472
	NP_003719
	NP_001280490 ; NP_033498
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 16, 2022

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.^[5]^[6]^[7]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.^[7]

Related Research Articles

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UNC is a set of proteins first identified through a set of screening tests in Caenorhabditis elegans, looking for roundworms with movement problems. Worms with which were un-coordinated were analysed in order to identify the genetic defect. Such proteins include UNC-5, a receptor for UNC-6 which is one of the netrins. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion (genetics) to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.

UNC-5 is a receptor for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182168 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059921 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature. 386 (6627): 833–8. Bibcode:1997Natur.386..833L. doi:10.1038/386833a0. PMID 9126742. S2CID 1232956.
↑ Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.
1 2 "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)".

Kennedy TE (2001). "Cellular mechanisms of netrin function: long-range and short-range actions". Biochem. Cell Biol. 78 (5): 569–75. doi:10.1139/bcb-78-5-569. PMID 11103947.
Livesey FJ (2001). "Netrins and netrin receptors". Cell. Mol. Life Sci. 56 (1–2): 62–8. doi:10.1007/s000180050006. PMID 11213262. S2CID 33776808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi: 10.1073/pnas.0738063100 . PMC 153067 . PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi: 10.1074/jbc.M302943200 . PMID 12810718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi: 10.1523/JNEUROSCI.3715-04.2004 . PMC 6730211 . PMID 15574733.
Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396 . PMID 15729359.
Bernet A, Mazelin L, Coissieux MM, et al. (2008). "Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies". Gastroenterology. 133 (6): 1840–8. doi:10.1053/j.gastro.2007.08.009. PMC 2211510 . PMID 17967459.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182168 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059921 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9126742-5] Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature. 386 (6627): 833–8. Bibcode:1997Natur.386..833L. doi:10.1038/386833a0. PMID 9126742. S2CID 1232956.

[pmid9782087-6] Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087.

[entrez-7] 1 2 "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)".

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UNC5C

Related Research Articles

References

Further reading