UPP1

UPP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EUE, 3EUF, 3NBQ
Identifiers
Aliases	UPP1 , UDRPASE, UP, UPASE, UPP, uridine phosphorylase 1
External IDs	OMIM: 191730; MGI: 1097668; HomoloGene: 2524; GeneCards: UPP1; OMA:UPP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p12.3 Start 48,088,628 bp [1] End 48,108,736 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 9,068,103 bp [2] End 9,086,170 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte upper lobe of left lung monocyte gonad blood buccal mucosa cell mucosa of transverse colon right frontal lobe right lung Top expressed in jejunum duodenum conjunctival fornix primary oocyte blastocyst granulocyte left colon corneal stroma mucous cell of stomach endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity catalytic activity pentosyltransferase activity glycosyltransferase activity uridine phosphorylase activity Cellular component cytoplasm cytosol nucleus nucleoplasm Biological process pyrimidine nucleoside salvage pyrimidine nucleotide metabolic process nucleoside metabolic process uridine metabolic process nucleotide catabolic process cellular response to glucose starvation nucleobase-containing compound metabolic process pyrimidine nucleoside catabolic process UMP salvage uridine catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7378 22271 Ensembl ENSG00000183696 ENSMUSG00000020407 UniProt Q16831 P52624 RefSeq (mRNA) NM_001287426 NM_001287428 NM_001287429 NM_001287430 NM_003364 NM_181597 NM_001362774 NM_001159401 NM_001159402 NM_009477 RefSeq (protein) NP_001274355 NP_001274357 NP_001274358 NP_001274359 NP_003355 NP_001349703 NP_001152873 NP_001152874 NP_033503 Location (UCSC) Chr 7: 48.09 – 48.11 Mb Chr 11: 9.07 – 9.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene. ^{[5] [6] [7]} It belongs to the uridine phosphorylase enzyme family.

Interactions

UPP1 has been shown to interact with Vimentin. ^[8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

1. GRCh38: Ensembl release 89: ENSG00000183696 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020407 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID   752472.
6. Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5. doi: 10.1002/ijc.10105 . PMID   11807789. S2CID   40565516.
7. "Entrez Gene: UPP1 uridine phosphorylase 1".
8. Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. 276 (16). United States: 13302–7. doi: 10.1074/jbc.M008512200 . ISSN   0021-9258. PMID   11278417.

Further reading

• Pizzorno G, Cao D, Leffert JJ, et al. (2002). "Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update". Biochim. Biophys. Acta. 1587 (2–3): 133–44. doi:10.1016/s0925-4439(02)00076-5. PMID   12084455.
• Watanabe S, Uchida T (1995). "Cloning and expression of human uridine phosphorylase". Biochem. Biophys. Res. Commun. 216 (1): 265–72. doi:10.1006/bbrc.1995.2619. PMID   7488099.
• Russell RL, Cao D, Zhang D, et al. (2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. 276 (16): 13302–7. doi: 10.1074/jbc.M008512200 . PMID   11278417.
• Miyashita H, Takebayashi Y, Eliason JF, et al. (2002). "Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma". Cancer. 94 (11): 2959–66. doi: 10.1002/cncr.10568 . PMID   12115385. S2CID   9484010.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Temmink OH, de Bruin M, Laan AC, et al. (2006). "The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells". Int. J. Biochem. Cell Biol. 38 (10): 1759–65. doi:10.1016/j.biocel.2006.04.007. PMID   16798057.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Uridine phosphorylase 1 (UPP1)