UPP1

Last updated
UPP1
Protein UPP1 PDB 3EUE.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UPP1 , UDRPASE, UP, UPASE, UPP, uridine phosphorylase 1
External IDs OMIM: 191730 MGI: 1097668 HomoloGene: 2524 GeneCards: UPP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001159401
NM_001159402
NM_009477

RefSeq (protein)

NP_001152873
NP_001152874
NP_033503

Location (UCSC) Chr 7: 48.09 – 48.11 Mb Chr 11: 9.07 – 9.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene. [5] [6] [7] It belongs to the uridine phosphorylase enzyme family.

Contents

Interactions

UPP1 has been shown to interact with Vimentin. [8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
FluoropyrimidineActivity WP1601.png go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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FluoropyrimidineActivity WP1601.png go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Related Research Articles

A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. The term often refers to nucleotide salvage in particular, in which nucleotides are synthesized from intermediates in their degradative pathway.

<span class="mw-page-title-main">Vimentin</span> Type III intermediate filament protein

Vimentin is a structural protein that in humans is encoded by the VIM gene. Its name comes from the Latin vimentum which refers to an array of flexible rods.

<span class="mw-page-title-main">Thymidine kinase 1</span> Protein-coding gene in the species Homo sapiens

Thymidine kinase 1, soluble, is a human thymidine kinase.

<span class="mw-page-title-main">TYMP (gene)</span> Protein-coding gene in the species Homo sapiens

TYMP is a gene that encodes for the enzyme thymidine phosphorylase. The TYMP gene is also known as ECGF1 and MNGIE due to its role in MNGIE syndrome.

<span class="mw-page-title-main">P2RY4</span> Protein-coding gene in the species Homo sapiens

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.

<span class="mw-page-title-main">Thymidine phosphorylase</span>

Thymidine phosphorylase is an enzyme that is encoded by the TYMP gene and catalyzes the reaction:

<span class="mw-page-title-main">PHKA2</span> Protein-coding gene in the species Homo sapiens

Phosphorylase b kinase regulatory subunit alpha, liver isoform is an enzyme that in humans is encoded by the PHKA2 gene.

<span class="mw-page-title-main">DNAJA1</span> Protein-coding gene in the species Homo sapiens

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

<span class="mw-page-title-main">SLC23A2</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

<span class="mw-page-title-main">PHKG1</span> Protein-coding gene in the species Homo sapiens

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKG1 gene.

<span class="mw-page-title-main">PLK2</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

<span class="mw-page-title-main">MAPKAPK5</span>

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

<span class="mw-page-title-main">PHKB</span> Protein-coding gene in the species Homo sapiens

Phosphorylase b kinase regulatory subunit beta is an enzyme that in humans is encoded by the PHKB gene.

<span class="mw-page-title-main">PHKG2</span> Protein-coding gene in the species Homo sapiens

Phosphorylase b kinase gamma catalytic chain, testis/liver isoform is an enzyme that in humans is encoded by the PHKG2 gene.

<span class="mw-page-title-main">HIC2</span> Protein-coding gene in the species Homo sapiens

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

<span class="mw-page-title-main">GPX7</span> Protein-coding gene in the species Homo sapiens

Glutathione peroxidase 7 is an enzyme that in humans is encoded by the GPX7 gene.

<span class="mw-page-title-main">Phosphorylase kinase, alpha 1</span> Protein-coding gene in the species Homo sapiens

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene. It is the muscle isoform of Phosphorylase kinase (PhK).

<span class="mw-page-title-main">ZNF267</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

<span class="mw-page-title-main">UCKL1</span> Protein-coding gene in the species Homo sapiens

Uridine-cytidine kinase-like 1 is an enzyme that in humans is encoded by the UCKL1 gene.

<span class="mw-page-title-main">DOK4</span> Protein-coding gene in the species Homo sapiens

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183696 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020407 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID   752472.
  6. Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5. doi: 10.1002/ijc.10105 . PMID   11807789. S2CID   40565516.
  7. "Entrez Gene: UPP1 uridine phosphorylase 1".
  8. Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. United States. 276 (16): 13302–7. doi: 10.1074/jbc.M008512200 . ISSN   0021-9258. PMID   11278417.

Further reading