USP25

USP25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MUX
Identifiers
Aliases	USP25 , USP21, ubiquitin specific peptidase 25
External IDs	OMIM: 604736 MGI: 1353655 HomoloGene: 8374 GeneCards: USP25
Gene location (Human)
Chr.	Chromosome 21 (human)
End	15,880,064 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	76,913,668 bp
RNA expression pattern
	Top expressed in
	sperm; ; amniotic fluid; ; biceps brachii; ; Achilles tendon; ; gastrocnemius muscle; ; vastus lateralis muscle; ; deltoid muscle; ; thoracic diaphragm; ; tibialis anterior muscle; ; endothelial cell;
	Top expressed in
	knee joint; ; ciliary body; ; spermatid; ; blood; ; vastus lateralis muscle; ; esophagus; ; triceps brachii muscle; ; retinal pigment epithelium; ; conjunctival fornix; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding ; peptidase activity ; cysteine-type peptidase activity ; ubiquitin binding ; protein binding ; hydrolase activity ; ubiquitin protein ligase binding ; thiol-dependent deubiquitinase ; ubiquitin-like protein-specific protease activity ; cysteine-type endopeptidase activity ;
Cellular component	endoplasmic reticulum ; nucleus ; cytoplasm ; cytosol ;
Biological process	protein K63-linked deubiquitination ; protein K48-linked deubiquitination ; negative regulation of ERAD pathway ; ubiquitin-dependent protein catabolic process ; proteolysis ; protein deubiquitination ; regulation of protein stability ;
	Sources:Amigo / QuickGO
Orthologs
	29761
	30940
	ENSG00000155313
	ENSMUSG00000022867
	Q9UHP3
	P57080
NM_001283041 ; NM_001283042 ; NM_013396 ; NM_001352560 ; NM_001352561 ;
	NM_001388299 ; NM_001388300 ; NM_001388301 ; NM_001388302 Contents Function ; References ; Further reading ;
	NM_013918
	NP_001269970 ; NP_001269971 ; NP_037528 ; NP_001339489 ; NP_001339490
	NP_038946
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 30, 2023

Ubiquitin specific peptidase 25 is a protein that in humans is encoded by the USP25 gene. ^[5]

Function

Ubiquitin is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008].

Related Research Articles

Ubiquitin specific peptidase 9, Y-linked , also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene.

Sentrin-specific protease 1 is an enzyme that in humans is encoded by the SENP1 gene.

Ubiquitin specific peptidase 10, also known as USP10, is an enzyme which in humans is encoded by the USP10 gene.

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.

Ubiquitin specific protease 4 (USP4) is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein is encoded by a gene containing 22 exons.

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene.

Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

Pitrilysin metallopeptidase 1 also known as presequence protease, mitochondrial (PreP) and metalloprotease 1 (MTP-1) is an enzyme that in humans is encoded by the PITRM1 gene. It is also sometimes called metalloprotease 1 (MP1).PreP facilitates proteostasis by utilizing an ~13300-A(3) catalytic chamber to degrade toxic peptides, including mitochondrial presequences and β-amyloid. Deficiency of PreP is found associated with Alzheimer’s disease. Reduced levels of PreP via RNAi mediated knockdown have been shown to lead to defective maturation of the protein Frataxin.

Ubiquitin carboxyl-terminal hydrolase 24 is an enzyme that in humans is encoded by the USP24 gene.

Ubiquitin specific processing protease 37 is an enzyme that in humans, is encoded by the USP37 gene.

Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17. USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155313 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022867 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ubiquitin specific peptidase 25" . Retrieved 2017-10-31.

Valero R, Bayés M, Francisca Sánchez-Font M, González-Angulo O, Gonzàlez-Duarte R, Marfany G (2001). "Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25". Genome Biol. 2 (10): RESEARCH0043. doi: 10.1186/gb-2001-2-10-research0043 . PMC 57798 . PMID 11597335.
Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T (2008). "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer". Genes Chromosomes Cancer. 47 (9): 810–8. doi:10.1002/gcc.20582. PMID 18523997. S2CID 39369334.
Meulmeester E, Kunze M, Hsiao HH, Urlaub H, Melchior F (2008). "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25". Mol. Cell. 30 (5): 610–9. doi:10.1016/j.molcel.2008.03.021. hdl: 11858/00-001M-0000-0012-DBA8-3 . PMID 18538659.
Denuc A, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (2009). "The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition". PLOS ONE. 4 (5): e5571. Bibcode:2009PLoSO...4.5571D. doi: 10.1371/journal.pone.0005571 . PMC 2679190 . PMID 19440361.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S (2010). "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients". Inflamm. Bowel Dis. 16 (6): 907–9. doi: 10.1002/ibd.21105 . PMID 19760754.
Cholay M, Reverdy C, Benarous R, Colland F, Daviet L (2010). "Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase". Exp. Cell Res. 316 (4): 667–75. doi:10.1016/j.yexcr.2009.10.023. PMID 19909739.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Kessler BM, Edelmann MJ (2011). "PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications". Cell Biochem. Biophys. 60 (1–2): 21–38. doi:10.1007/s12013-011-9176-6. PMC 3094536 . PMID 21480003.
Blount JR, Burr AA, Denuc A, Marfany G, Todi SV (2012). "Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation". PLOS ONE. 7 (5): e36542. Bibcode:2012PLoSO...736542B. doi: 10.1371/journal.pone.0036542 . PMC 3348923 . PMID 22590560.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155313 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022867 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin specific peptidase 25" . Retrieved 2017-10-31.

[1]

[2]

[3]

[4]

[5]

USP25

Contents

Function

Related Research Articles

References

Further reading