USP39

USP39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	USP39 , 65K, HSPC332, SAD1, SNRNP65, CGI-21, ubiquitin specific peptidase 39
External IDs	OMIM: 611594 MGI: 107622 HomoloGene: 13183 GeneCards: USP39
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,649,283 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,322,167 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; gastrocnemius muscle; ; monocyte; ; stromal cell of endometrium; ; upper lobe of left lung; ; right lung; ; right coronary artery; ; popliteal artery; ; islet of Langerhans; ; rectum;
	Top expressed in
	spermatocyte; ; placenta; ; yolk sac; ; ganglionic eminence; ; bone marrow; ; lung; ; secondary oocyte; ; thymus; ; neural tube; ; mesencephalon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase ; zinc ion binding ; metal ion binding ; protein binding ;
Cellular component	spliceosomal complex ; nucleus ; nucleoplasm ; U4/U6 x U5 tri-snRNP complex ;
Biological process	protein deubiquitination ; mRNA splicing, via spliceosome ; cell cycle ; mRNA processing ; RNA splicing ; cell division ; spliceosomal complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	10713
	28035
	ENSG00000168883
	ENSMUSG00000056305
	Q53GS9
	Q3TIX9
	NM_001256725 ; NM_001256726 ; NM_001256727 ; NM_001256728 ; NM_006590
	NM_138592
	NP_001243654 ; NP_001243655 ; NP_001243656 ; NP_001243657 ; NP_006581
	NP_613058
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.^[5]^[6]

Related Research Articles

U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

LUC7 like 3 pre-mRNA splicing factor (LUC7L3), also known as Cisplatin resistance-associated overexpressed protein, or CROP, is a human gene.

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.

Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.

Solute carrier family 35 member C2 is a protein that in humans is encoded by the SLC35C2 gene.

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.

Protein GPR89 is a protein that in humans is encoded by the GPR89B gene.

Methyltransferase-like protein 13 is an enzyme that in humans is encoded by the METTL13 gene.

Putative RNA-binding protein Luc7-like 1 is a protein that in humans is encoded by the LUC7L gene.

Zinc finger protein 330 is a protein that in humans is encoded by the ZNF330 gene.

THAP domain-containing protein 4 is a protein that in humans is encoded by the THAP4 gene.

Phosphorylated adapter RNA export protein is a protein that in humans is encoded by the PHAX gene.

RNA-binding protein 28 is a protein that in humans is encoded by the RBM28 gene. It is a nucleolar component of the spliceosomal ribonucleoprotein complexes.

Zinc finger protein 64 homolog, isoforms 1 and 2 is a protein that in humans is encoded by the ZFP64 gene.

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.

Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene.

Putative survival-related protein is a protein that in humans is encoded by the CASZ1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168883 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056305 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ "Entrez Gene: USP39 ubiquitin specific peptidase 39".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lygerou Z, Christophides G, Séraphin B (1999). "A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing". Mol. Cell. Biol. 19 (3): 2008–20. doi:10.1128/mcb.19.3.2008. PMC 83994 . PMID 10022888.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–2563. doi:10.1093/emboj/20.10.2553. PMC 125249 . PMID 11350945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168883 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056305 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP39 ubiquitin specific peptidase 39".

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USP39

Related Research Articles

References

Further reading