USP6NL

USP6NL
Identifiers
Aliases	USP6NL , RNTRE, TRE2NL, USP6NL-IT1, USP6 N-terminal like
External IDs	OMIM: 605405 MGI: 2138893 HomoloGene: 6879 GeneCards: USP6NL
Gene location (Human)
Chr.	Chromosome 10 (human)
End	11,611,666 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	6,451,201 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; sperm; ; cavity of mouth; ; gums; ; thymus; ; palpebral conjunctiva; ; tibia; ; ganglionic eminence; ; islet of Langerhans; ; testicle;
	Top expressed in
	sciatic nerve; ; otolith organ; ; utricle; ; hand; ; hair follicle; ; retinal pigment epithelium; ; pineal gland; ; conjunctival fornix; ; foot; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ;
Cellular component	plasma membrane ; Golgi apparatus ; cytoplasmic vesicle ; cytosol ; endomembrane system ; trans-Golgi network membrane ;
Biological process	regulation of cilium assembly ; retrograde transport, plasma membrane to Golgi ; regulation of Golgi organization ; Golgi organization ; plasma membrane to endosome transport ; activation of GTPase activity ; regulation of vesicle fusion ; intracellular protein transport ; positive regulation of GTPase activity ;
	Sources:Amigo / QuickGO
Orthologs
	9712
	98910
	ENSG00000148429
	ENSMUSG00000039046
	Q92738
	Q80XC3
	NM_001080491 ; NM_014688 ; NM_001391959 ; NM_001391960 ; NM_001391961
	NM_001080548 ; NM_181399
	NP_001073960 ; NP_055503
	NP_001074017 ; NP_852064
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

USP6 N-terminal-like protein is a protein that in humans is encoded by the USP6NL gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148429 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039046 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Matòsková B, Wong WT, Seki N, Nagase T, Nomura N, Robbins KC, Di Fiore PP (Jun 1996). "RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain". Oncogene. 12 (12): 2563–71. PMID 8700515.
↑ Matòsková B, Wong WT, Nomura N, Robbins KC, Di Fiore PP (Jun 1996). "RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation". Oncogene. 12 (12): 2679–88. PMID 8700527.
↑ "Entrez Gene: USP6NL USP6 N-terminal like".

Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID 7584026.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Research. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID 7584028.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (Nov 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
Martinu L, Santiago-Walker A, Qi H, Chou MM (Dec 2002). "Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre". The Journal of Biological Chemistry. 277 (52): 50996–1002. doi: 10.1074/jbc.M204869200 . PMID 12399475.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Lanzetti L, Palamidessi A, Areces L, Scita G, Di Fiore PP (May 2004). "Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases". Nature. 429 (6989): 309–14. doi:10.1038/nature02542. PMID 15152255. S2CID 4431181.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Lanzetti L, Margaria V, Melander F, Virgili L, Lee MH, Bartek J, Jensen S (May 2007). "Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells". The Journal of Biological Chemistry. 282 (20): 15258–70. doi: 10.1074/jbc.M700914200 . PMID 17371873.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148429 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039046 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8700515-5] Matòsková B, Wong WT, Seki N, Nagase T, Nomura N, Robbins KC, Di Fiore PP (Jun 1996). "RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain". Oncogene. 12 (12): 2563–71. PMID 8700515.

[pmid8700527-6] Matòsková B, Wong WT, Nomura N, Robbins KC, Di Fiore PP (Jun 1996). "RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation". Oncogene. 12 (12): 2679–88. PMID 8700527.

[entrez-7] "Entrez Gene: USP6NL USP6 N-terminal like".

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USP6NL

Related Research Articles

References

Further reading