UVRAG

UVRAG
Identifiers
Aliases	UVRAG , DHTX, VPS38, p63, UV radiation resistance associated
External IDs	OMIM: 602493 MGI: 1925860 HomoloGene: 31150 GeneCards: UVRAG
Gene location (Human)
Chr.	Chromosome 11 (human)
End	76,144,232 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,790,348 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; subcutaneous adipose tissue; ; abdominal fat; ; monocyte; ; parietal pleura; ; lymph node; ; thymus; ; sural nerve; ; tibia;
	Top expressed in
	calvaria; ; spleen; ; secondary oocyte; ; thymus; ; spermatocyte; ; subcutaneous adipose tissue; ; right lung; ; blood; ; liver; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding ; protein binding ; SNARE binding ;
Cellular component	cytoplasm ; HOPS complex ; endosome ; late endosome ; centrosome ; chromosome ; midbody ; early endosome ; phagocytic vesicle ; endoplasmic reticulum ; DNA-dependent protein kinase complex ; lysosome ; chromosome, centromeric region ; protein-containing complex ; autophagosome membrane ; autophagosome ; cytoplasmic vesicle ;
Biological process	double-strand break repair via classical nonhomologous end joining ; regulation of cytokinesis ; regulation of protein serine/threonine kinase activity ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; multivesicular body sorting pathway ; chromosome segregation ; regulation of vesicle-mediated transport ; receptor catabolic process ; cellular response to DNA damage stimulus ; autophagy ; spindle organization ; viral entry into host cell ; maintenance of Golgi location ; DNA repair ; SNARE complex assembly ; positive regulation of autophagosome maturation ; centrosome cycle ; autophagosome maturation ;
	Sources:Amigo / QuickGO
Orthologs
	7405
	78610
	ENSG00000198382
	ENSMUSG00000035354
	Q9P2Y5
	Q8K245
	NM_003369
	NM_178635
	NP_003360
	NP_848750
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 15, 2023

UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.^[5]^[6]

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.

Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198382 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035354 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D (Jul 1997). "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus". Genomics. 41 (3): 397–405. doi: 10.1006/geno.1997.4623 . PMID 9169138.
1 2 "Entrez Gene: UVRAG UV radiation resistance associated gene".

Liang C, Feng P, Ku B, et al. (2007). "UVRAG: a new player in autophagy and tumor cell growth". Autophagy. 3 (1): 69–71. doi: 10.4161/auto.3437 . PMID 17106237.
Teitz T, Penner M, Eli D, et al. (1990). "Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells". Gene. 87 (2): 295–298. doi:10.1016/0378-1119(90)90316-J. PMID 2332174.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bekri S, Adélaïde J, Merscher S, et al. (1998). "Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma". Cytogenet. Cell Genet. 79 (1–2): 125–131. doi:10.1159/000134699. PMID 9533029.
Iida A, Emi M, Matsuoka R, et al. (2000). "Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation". Hum. Genet. 106 (3): 277–287. doi:10.1007/s004390051038. PMID 10798355.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Goi T, Kawasaki M, Yamazaki T, et al. (2004). "Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case". Surg. Today. 33 (9): 702–706. doi:10.1007/s00595-002-2567-y. PMID 12928850. S2CID 29935419.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Ionov Y, Nowak N, Perucho M, et al. (2004). "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability". Oncogene. 23 (3): 639–645. doi:10.1038/sj.onc.1207178. PMID 14737099.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Liang C, Feng P, Ku B, et al. (2006). "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG". Nat. Cell Biol. 8 (7): 688–698. doi:10.1038/ncb1426. PMID 16799551. S2CID 19739498.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198382 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035354 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169138-5] Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D (Jul 1997). "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus". Genomics. 41 (3): 397–405. doi: 10.1006/geno.1997.4623 . PMID 9169138.

[entrez-6] 1 2 "Entrez Gene: UVRAG UV radiation resistance associated gene".

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UVRAG

Related Research Articles

References

Further reading