UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene. [5] [6]
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.
Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [6]
XPB is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
UV excision repair protein RAD23 homolog B is a protein that in humans is encoded by the RAD23B gene.
Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. XPC is involved in the recognition of bulky DNA adducts in nucleotide excision repair. It is located on chromosome 3.
DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.
PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.
Autophagy-related protein 10 is a protein that in humans is encoded by the ATG10 gene.
Coronin-1C is a protein that in humans is encoded by the CORO1C gene.
Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.
Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene.
KIAA0196 is a human gene. The product is a protein that is a component of the WASH complex, which regulates actin assembly on intracellular vesicles. Mutations in KIAA0196 are implicated in some forms of hereditary spastic paraplegia.
Zinc finger protein 330 is a protein that in humans is encoded by the ZNF330 gene.
RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.
Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.
Synaptonemal complex protein SC65, also known as Leprecan-like protein 4 (LEPREL4) or nucleolar autoantigen No55, is a protein that in humans is encoded by the LEPREL4 gene.
Serologically defined colon cancer antigen 8 is a protein that in humans is encoded by the SDCCAG8 gene. This protein localizes to the centrioles.
Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.
Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.