Ubiquitin-fold modifier conjugating enzyme 1

UFC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K07, 2Z6O, 2Z6P, 3EVX
Identifiers
Aliases	UFC1 , HSPC155, ubiquitin-fold modifier conjugating enzyme 1, NEDSG
External IDs	OMIM: 610554 MGI: 1913405 HomoloGene: 9500 GeneCards: UFC1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,158,856 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,295,024 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; body of pancreas; ; caudate nucleus; ; islet of Langerhans; ; nucleus accumbens; ; body of stomach; ; rectum; ; pituitary gland; ; anterior pituitary;
	Top expressed in
	parotid gland; ; facial motor nucleus; ; islet of Langerhans; ; lacrimal gland; ; seminal vesicula; ; calvaria; ; Paneth cell; ; medial ganglionic eminence; ; mirror; ; Epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; UFM1 transferase activity ;
Cellular component	extracellular exosome ; cytoplasm ;
Biological process	protein K69-linked ufmylation ; response to endoplasmic reticulum stress ; protein ufmylation ; brain development ;
	Sources:Amigo / QuickGO
Orthologs
	51506
	66155
	ENSG00000143222
	ENSMUSG00000062963
	Q9Y3C8
	Q9CR09
	NM_016406
	NM_025388
	NP_057490
	NP_079664 ; NP_001347860 ; NP_001347861 ; NP_001347862
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene. ^[5]

Function

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008].

Related Research Articles

Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes. This protein has been linked to X-linked spinal muscular atrophy type 2, neurodegenerative diseases, and cancers.

Small ubiquitin-related modifier 2 is a protein that in humans is encoded by the SUMO2 gene.

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.

NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene.

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.

Ubiquitin-conjugating enzyme E2 E2 is a protein that in humans is encoded by the UBE2E2 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene.

Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene.

<span class="mw-page-title-main">URM1</span>

Ubiquitin-related modifier-1 (URM1) is a ubiquitin-like protein that modifies proteins in the yeast ubiquitin-like urmylation pathway. Structural comparisons and phylogenetic analysis of the ubiquitin superfamily has indicated that Urm1 has the most conserved structural and sequence features of the common ancestor of the entire superfamily.

Ubiquitin conjugating enzyme E2 Z (UBE2Z), also known as UBA6-specific E2 enzyme 1 (USE1), is an enzyme that in humans is encoded by the UBE2Z gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. UBE2Z is an E2 ubiquitin conjugating enzyme and participates in the second step of protein ubiquitination during proteolysis. A genome-wide association study (GWAS) revealed the UBE2Z gene to be associated with chronic kidney disease. The UBE2Z gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143222 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062963 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ubiquitin-fold modifier conjugating enzyme 1" . Retrieved 2020-04-15.

Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J. 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC 404325 . PMID 15071506.
Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T (April 2009). "NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway". J. Struct. Funct. Genomics. 10 (2): 127–36. doi:10.1007/s10969-008-9054-7. PMC 2850604 . PMID 19101823.
Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S (June 2014). "Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1)". Exp. Cell Res. 324 (2): 192–9. doi:10.1016/j.yexcr.2014.04.003. PMID 24726913.
Xie S (August 2014). "Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex". Acta Crystallogr F. 70 (Pt 8): 1093–7. doi:10.1107/S2053230X14014502. PMC 4118812 . PMID 25084390.
Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT (February 2015). "Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections". HIV Med. 16 (2): 114–21. doi: 10.1111/hiv.12194 . PMID 25213431.
Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D, Liu L (February 2015). "The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells". Gastroenterology. 148 (2): 415–26.e18. doi:10.1053/j.gastro.2014.10.012. PMID 25449213.
Zhang G, Wu Y, Xu D, Yan X (November 2016). "Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a". DNA Cell Biol. 35 (11): 691–695. doi:10.1089/dna.2016.3397. PMID 27529373.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143222 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062963 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin-fold modifier conjugating enzyme 1" . Retrieved 2020-04-15.

[1]

[2]

[3]

[4]

[5]

Ubiquitin-fold modifier conjugating enzyme 1

Contents

Function

Related Research Articles

References

Further reading