Urethral hypermobility

Last updated

Urethral hypermobility is a condition of excessive movement of the female urethra due to a weakened urogenital diaphragm. It describes the instability of the urethra in relation to the pelvic floor muscles. A weakened pelvic floor muscle fails to adequately close the urethra and hence can cause stress urinary incontinence. This condition may be diagnosed by primary care providers or urologists. Treatment may include pelvic floor muscle exercises, surgery (e.g. urethral sling), or minimally invasive procedures (e.g. urethral bulking injections). [1] [2]

Contents

Anatomy

Muscles of the pelvic floor in males and females and location of urethra. 1116 Muscle of the Perineum.jpg
Muscles of the pelvic floor in males and females and location of urethra.

The urethra is held in place in relationship to the pelvic bones and bladder by a combination of ligaments, pelvic floor muscles, and surrounding connective tissue known as the urogenital diaphragm. Damage to any of these structures, or the nerves that control them can cause the urethra to be displaced from its normal position or to have increased range of motion. This can result in lack of effective closure of the urethra and thus urinary leakage, especially when pressure from the abdomen is increased during physical exertion and cough, sneeze, or valsalva maneuvers. [3]

Pelvic organs including bladder and urethra in both males and females. Female and Male Urethra.jpg
Pelvic organs including bladder and urethra in both males and females.

Female anatomical considerations

Changes during pregnancy and physical trauma during childbirth can cause damage to the pubosacral ligament, uterosacral ligament, and pelvic floor muscles, and the connection of the pubic bone itself. Any of these changes may contribute to urethral hypermobility. [1]

Male anatomical considerations

Males have a lower incidence of urethral hypermobility than females, but prostatectomy is one risk factor urethral hypermobility and stress incontinence. [4]

Diagnosis

Urethral hypermobility is often diagnosed indirectly by achieving a diagnosis of stress urinary incontinence. This could include ruling out other types of incontinence and other abnormalities, and specific tests for stress incontinence, for example testing for urinary leakage during cough. Specialized testing to further characterize the degree of urethral hypermobility may include urodynamic testing, voiding cystourethrography, pelvic ultrasound, and electromyography. [5] These modalities are only recommended for people who experience ongoing symptoms despite an adequate trial of pelvic floor muscle training. [6]

Treatment

Pelvic Floor Muscle Training

The first line treatment for urethral hypermobility is pelvic floor exercises under supervision of a physical therapist. However, there is no consensus on which training regiments are most effective, and studies have not determined which mechanisms improve the function of the pelvic floor muscles (e.g. improving reflex action of muscles in response to abdominal pressure vs. increasing urethral closing pressure). [1] [7]

Weight Loss

Loss of 5-10% of weight has been shown to result in mild improvement in symptoms that was persistent across follow-up periods of 1-3 years. [1]

Medication

Duloxetine is a medication in the Serotonin–norepinephrine reuptake inhibitor class which is approved in Europe for treatment of stress urinary incontinence and used off-label in America for the treatment of stress urinary incontinence. [1]

Surgery

Several surgical procedures are available to treat urethral hypermobility. These procedures use combinations of sutures, implanted synthetic mesh, and autotransplanted tissue to support and reposition the urethra in relation to the pubic bone and other pelvic structures.

Surgical meshes have come to the public attention due to safety concerns with vaginal mesh used to treat pelvic organ prolapse, however, the urethral sling surgeries have been demonstrated to be highly effective with low risk of adverse events. [1]

Other procedures

Urethral bulking involves injecting an inert material into the wall of the urethra to relieve the symptoms of urethral hypermobility. This technique is less invasive than surgery with lower risk of adverse events, however it has a lower cure rate for stress incontinence than other methods. [1]

Lifestyle Interventions

Lifestyle interventions such as limiting water intake and scheduling urination are not proven to be effective. [1]

Research areas

Stem-cell therapy and Electrical muscle stimulation are being explored to assist regeneration of damaged tissue and muscle growth in the urogenital diaphragm. These trials have been explored in animals in vivo and In vitro studies, but have not yet been explored in humans. [8]


Reference

  1. 1 2 3 4 5 6 7 8 Wu JM (June 2021). Solomon CG (ed.). "Stress Incontinence in Women". The New England Journal of Medicine. 384 (25): 2428–2436. doi:10.1056/NEJMcp1914037. PMID   34161707. S2CID   235625388.
  2. Cho ST, Kim KH (December 2021). "Pelvic floor muscle exercise and training for coping with urinary incontinence". Journal of Exercise Rehabilitation. 17 (6): 379–387. doi:10.12965/jer.2142666.333. PMC   8743604 . PMID   35036386.
  3. Quaghebeur J, Petros P, Wyndaele JJ, De Wachter S (October 2021). "Pelvic-floor function, dysfunction, and treatment". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 265: 143–149. doi:10.1016/j.ejogrb.2021.08.026. hdl: 10067/1824640151162165141 . PMID   34492609.
  4. Canning A, Raison N, Aydin A, Cheikh Youssef S, Khan S, Dasgupta P, Ahmed K (November 2022). "A systematic review of treatment options for post-prostatectomy incontinence". World Journal of Urology. 40 (11): 2617–2626. doi:10.1007/s00345-022-04146-5. PMC   9617828 . PMID   36107210.
  5. Falah-Hassani K, Reeves J, Shiri R, Hickling D, McLean L (March 2021). "The pathophysiology of stress urinary incontinence: a systematic review and meta-analysis". International Urogynecology Journal. 32 (3): 501–552. doi:10.1007/s00192-020-04622-9. PMC   8053188 . PMID   33416968.
  6. Hu JS, Pierre EF (September 2019). "Urinary Incontinence in Women: Evaluation and Management". American Family Physician. 100 (6): 339–348. PMID   31524367.
  7. Sheng Y, Carpenter JS, Ashton-Miller JA, Miller JM (May 2022). "Mechanisms of pelvic floor muscle training for managing urinary incontinence in women: a scoping review". BMC Women's Health. 22 (1): 161. doi: 10.1186/s12905-022-01742-w . PMC   9103460 . PMID   35562699.
  8. Harland N, Walz S, Eberli D, Schmid FA, Aicher WK, Stenzl A, Amend B (September 2023). "Stress Urinary Incontinence: An Unsolved Clinical Challenge". Biomedicines. 11 (9): 2486. doi: 10.3390/biomedicines11092486 . PMC   10525672 . PMID   37760927.

Related Research Articles

<span class="mw-page-title-main">Urethra</span> Tube that connects the urinary bladder to the external urethral orifice

The urethra is the tube that connects the urinary bladder to the urinary meatus, through which placental mammals urinate and ejaculate. In non-mammalian vertebrates, the urethra also transports semen but is separate from the urinary tract.

<span class="mw-page-title-main">Urinary incontinence</span> Uncontrolled leakage of urine

Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine. It is a common and distressing problem, which may have a large impact on quality of life. It has been identified as an important issue in geriatric health care. The term enuresis is often used to refer to urinary incontinence primarily in children, such as nocturnal enuresis. UI is an example of a stigmatized medical condition, which creates barriers to successful management and makes the problem worse. People may be too embarrassed to seek medical help, and attempt to self-manage the symptom in secrecy from others.

<span class="mw-page-title-main">Levator ani</span> Broad, thin muscle group, situated on either side of the pelvis

The levator ani is a broad, thin muscle group, situated on either side of the pelvis. It is formed from three muscle components: the pubococcygeus, the iliococcygeus, and the puborectalis.

<span class="mw-page-title-main">Pelvic floor</span> Anatomical structure

The pelvic floor or pelvic diaphragm is an anatomical location in the human body, which has an important role in urinary and anal continence, sexual function and support of the pelvic organs. The pelvic floor includes muscles, both skeletal and smooth, ligaments and fascia. and separates between the pelvic cavity from above, and the perineum from below. It is formed by the levator ani muscle and coccygeus muscle, and associated connective tissue.

<span class="mw-page-title-main">Pelvic floor dysfunction</span> Medical condition

Pelvic floor dysfunction is a term used for a variety of disorders that occur when pelvic floor muscles and ligaments are impaired. The condition affects up to 50 percent of women who have given birth. Although this condition predominantly affects women, up to 16 percent of men are affected as well. Symptoms can include pelvic pain, pressure, pain during sex, urinary incontinence (UI), overactive bladder, bowel incontinence, incomplete emptying of feces, constipation, myofascial pelvic pain and pelvic organ prolapse. When pelvic organ prolapse occurs, there may be visible organ protrusion or a lump felt in the vagina or anus. Research carried out in the UK has shown that symptoms can restrict everyday life for women. However, many people found it difficult to talk about it and to seek care, as they experienced embarrassment and stigma.

<span class="mw-page-title-main">Urogenital diaphragm</span> Layer of the pelvis

Older texts have asserted the existence of a urogenital diaphragm, also called the triangular ligament, which was described as a layer of the pelvis that separates the deep perineal sac from the upper pelvis, lying between the inferior fascia of the urogenital diaphragm and superior fascia of the urogenital diaphragm.

<span class="mw-page-title-main">Transurethral resection of the prostate</span> Surgical procedure to perform a prostatectomy

Transurethral resection of the prostate is a urological operation. It is used to treat benign prostatic hyperplasia (BPH). As the name indicates, it is performed by visualising the prostate through the urethra and removing tissue by electrocautery or sharp dissection. It has been the standard treatment for BPH for many years, but recently alternative, minimally invasive techniques have become available. This procedure is done with spinal or general anaesthetic. A triple lumen catheter is inserted through the urethra to irrigate and drain the bladder after the surgical procedure is complete. The outcome is considered excellent for 80–90% of BPH patients. The procedure carries minimal risk for erectile dysfunction, moderate risk for bleeding, and a large risk for retrograde ejaculation.

<span class="mw-page-title-main">Cystocele</span> Protrusion of the bladder into the vagina

The cystocele, also known as a prolapsed bladder, is a medical condition in which a woman's bladder bulges into her vagina. Some may have no symptoms. Others may have trouble starting urination, urinary incontinence, or frequent urination. Complications may include recurrent urinary tract infections and urinary retention. Cystocele and a prolapsed urethra often occur together and is called a cystourethrocele. Cystocele can negatively affect quality of life.

<span class="mw-page-title-main">Prostatectomy</span> Surgical removal of all or part of the prostate gland

Prostatectomy is the surgical removal of all or part of the prostate gland. This operation is done for benign conditions that cause urinary retention, as well as for prostate cancer and for other cancers of the pelvis.

<span class="mw-page-title-main">Pelvic organ prolapse</span> Descent of the pelvic organs from their normal positions

Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions into the vagina. In women, the condition usually occurs when the pelvic floor collapses after gynecological cancer treatment, childbirth or heavy lifting. Injury incurred to fascia membranes and other connective structures can result in cystocele, rectocele or both. Treatment can involve dietary and lifestyle changes, physical therapy, or surgery.

<span class="mw-page-title-main">Radical retropubic prostatectomy</span>

Radical retropubic prostatectomy is a surgical procedure in which the prostate gland is removed through an incision in the abdomen. It is most often used to treat individuals who have early prostate cancer. Radical retropubic prostatectomy can be performed under general, spinal, or epidural anesthesia and requires blood transfusion less than one-fifth of the time. Radical retropubic prostatectomy is associated with complications such as urinary incontinence and impotence, but these outcomes are related to a combination of individual patient anatomy, surgical technique, and the experience and skill of the surgeon.

<span class="mw-page-title-main">Stress incontinence</span> Form of urinary incontinence from an inadequate closure of the bladder

Stress incontinence, also known as stress urinary incontinence (SUI) or effort incontinence is a form of urinary incontinence. It is due to inadequate closure of the bladder outlet by the urethral sphincter.

<span class="mw-page-title-main">Perineal membrane</span> Anatomical term

The perineal membrane is an anatomical term for a fibrous membrane in the perineum. The term "inferior fascia of urogenital diaphragm", used in older texts, is considered equivalent to the perineal membrane.

<span class="mw-page-title-main">Retropubic space</span>

Retropubic space is a potential avascular space located between the pubic symphysis and the urinary bladder. The retropubic space is a preperitoneal space, located behind the transversalis fascia and in front of peritoneum.

<span class="mw-page-title-main">Urethral sphincters</span> Muscles keeping urine in the bladder

The urethral sphincters are two muscles used to control the exit of urine in the urinary bladder through the urethra. The two muscles are either the male or female external urethral sphincter and the internal urethral sphincter. When either of these muscles contracts, the urethra is sealed shut.

<span class="mw-page-title-main">Artificial urinary sphincter</span> Medical device

An artificial urinary sphincter (AUS) is an implanted device to treat moderate to severe stress urinary incontinence, most commonly in men. The AUS is designed to supplement the function of the natural urinary sphincter that restricts urine flow out of the bladder.

A urethral bulking injection is a gynecological procedure and medical treatment used to treat involuntary leakage of urine: urinary incontinence in women. Injectional materials are used to control stress incontinence. Bulking agents are injected into the mucosa surrounding the bladder neck and proximal urethra. This reduces the diameter of the urethra and creates resistance to urine leakage. After the procedure, the pressure forcing the urine from the bladder through the urethra is resisted by the addition of the bulking agent in the tissue surrounding the proximal urethra. Most of the time this procedure prevents urinary stress incontinence in women.

<span class="mw-page-title-main">Surgery for benign prostatic hyperplasia</span> Type of surgery

If medical treatment is not effective, surgery may need to be performed for benign prostatic hyperplasia.

<span class="mw-page-title-main">Vaginal support structures</span> Structures that maintain the position of the vagina within the pelvic cavity

The vaginal support structures are those muscles, bones, ligaments, tendons, membranes and fascia, of the pelvic floor that maintain the position of the vagina within the pelvic cavity and allow the normal functioning of the vagina and other reproductive structures in the female. Defects or injuries to these support structures in the pelvic floor leads to pelvic organ prolapse. Anatomical and congenital variations of vaginal support structures can predispose a woman to further dysfunction and prolapse later in life. The urethra is part of the anterior wall of the vagina and damage to the support structures there can lead to incontinence and urinary retention.

Transvaginal mesh, also known as vaginal mesh implant, is a net-like surgical tool that is used to treat pelvic organ prolapse (POP) and stress urinary incontinence (SUI) among female patients. The surgical mesh is placed transvaginally to reconstruct weakened pelvic muscle walls and to support the urethra or bladder.