VCPIP1

VCPIP1
Identifiers
Aliases	VCPIP1 , DUBA3, VCIP135, valosin containing protein (p97)/p47 complex interacting protein 1, valosin containing protein interacting protein 1
External IDs	OMIM: 611745 MGI: 1917925 HomoloGene: 11814 GeneCards: VCPIP1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	66,667,231 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	9,818,607 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Achilles tendon; ; secondary oocyte; ; monocyte; ; middle temporal gyrus; ; internal globus pallidus; ; Brodmann area 23; ; stromal cell of endometrium; ; blood; ; islet of Langerhans;
	Top expressed in
	substantia nigra; ; superior cervical ganglion; ; hand; ; otolith organ; ; lateral geniculate nucleus; ; utricle; ; cumulus cell; ; trigeminal ganglion; ; mammillary body; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase ; peptidase activity ; cysteine-type peptidase activity ; hydrolase activity ;
Cellular component	cytoplasm ; Golgi stack ; Golgi apparatus ; endoplasmic reticulum ; endoplasmic reticulum lumen ;
Biological process	endoplasmic reticulum membrane fusion ; protein K48-linked deubiquitination ; Golgi organization ; protein ubiquitination ; protein K11-linked deubiquitination ; proteolysis ; Golgi reassembly ; mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	80124
	70675
	ENSG00000175073
	ENSMUSG00000045210
	Q96JH7
	Q8CDG3
	NM_025054
	NM_173443
	NP_079330
	NP_775619
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Deubiquitinating protein VCIP135 is a protein that in humans is encoded by the VCPIP1 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175073 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045210 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (Apr 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID 11347906.
↑ Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE (Mar 2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". The Journal of Biological Chemistry. 278 (13): 11579–89. doi: 10.1074/jbc.M202325200 . PMID 12509440.
↑ "Entrez Gene: VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1".

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H (Dec 2002). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". The Journal of Cell Biology. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMC 2173386 . PMID 12473691.
Wang Y, Satoh A, Warren G, Meyer HH, Wang Y (Mar 2004). "VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments". The Journal of Cell Biology. 164 (7): 973–8. doi:10.1083/jcb.200401010. PMC 2172062 . PMID 15037600.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175073 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045210 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11347906-5] Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (Apr 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID 11347906.

[pmid12509440-6] Ficarro S, Chertihin O, Westbrook VA, White F, Jayes F, Kalab P, Marto JA, Shabanowitz J, Herr JC, Hunt DF, Visconti PE (Mar 2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". The Journal of Biological Chemistry. 278 (13): 11579–89. doi: 10.1074/jbc.M202325200 . PMID 12509440.

[entrez-7] "Entrez Gene: VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1".

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VCPIP1

Related Research Articles

References

Further reading