VNN1

VNN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CYF, 4CYG, 4CYY
Identifiers
Aliases	VNN1 , HDLCQ8, Tiff66, vanin 1
External IDs	MGI: 108395 HomoloGene: 32130 GeneCards: VNN1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q23.2 Start 132,680,849 bp [1] End 132,714,055 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A4 Start 23,770,586 bp [2] End 23,781,241 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum gallbladder liver right lobe of liver pancreatic epithelial cell kidney tubule blood pancreatic ductal cell bone marrow Top expressed in jejunum proximal tubule intestinal villus left lung lobe renal corpuscle kidney left lobe of liver parotid gland morula medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity pantetheine hydrolase activity Cellular component integral component of membrane membrane anchored component of membrane extracellular region plasma membrane azurophil granule membrane Biological process positive regulation of T cell differentiation in thymus response to oxidative stress nitrogen compound metabolic process acute inflammatory response negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway innate immune response inflammatory response chronic inflammatory response pantothenate metabolic process neutrophil degranulation cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8876 22361 Ensembl ENSG00000112299 ENSMUSG00000037440 UniProt O95497 Q9Z0K8 RefSeq (mRNA) NM_004666 NM_011704 RefSeq (protein) NP_004657 NP_035834 Location (UCSC) Chr 6: 132.68 – 132.71 Mb Chr 10: 23.77 – 23.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene. ^{[5] [6]}

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000112299 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037440 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID   9790769.
6. "Entrez Gene: VNN1 vanin 1".

Further reading

• Aurrand-Lions M, Galland F, Bazin H, et al. (1997). "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing". Immunity. 5 (5): 391–405. doi: 10.1016/S1074-7613(00)80496-3 . PMID   8934567.
• Maras B, Barra D, Dupré S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. doi:10.1016/S0014-5793(99)01439-8. PMID   10567687. S2CID   25738323.
• Martin F, Malergue F, Pitari G, et al. (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID   11491533. S2CID   10763223.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell. Proteomics. 3 (7): 715–28. doi: 10.1074/mcp.M400015-MCP200 . PMID   15084671.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Min-Oo G, Fortin A, Pitari G, et al. (2007). "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus". J. Exp. Med. 204 (3): 511–24. doi:10.1084/jem.20061252. PMC   2137903 . PMID   17312006.