VPRBP

DCAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WA0, 4CC9, 4P7I, 4PXW, 4Z8L, 5AJA
Identifiers
Aliases	DCAF1 , VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP
External IDs	OMIM: 617259 MGI: 2445220 HomoloGene: 8805 GeneCards: DCAF1
EC number	2.7.11.1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,500,015 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,758,191 bp
RNA expression pattern
	Top expressed in
	sperm; ; pericardium; ; vena cava; ; gastrocnemius muscle; ; ganglionic eminence; ; body of tongue; ; biceps brachii; ; renal medulla; ; middle temporal gyrus; ; cardia;
	Top expressed in
	spermatid; ; secondary oocyte; ; spermatocyte; ; entorhinal cortex; ; extensor digitorum longus muscle; ; plantaris muscle; ; primitive streak; ; medial ganglionic eminence; ; parotid gland; ; corneal stroma;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; kinase activity ; histone kinase activity (H2A-T120 specific) ; protein serine/threonine kinase activity ; protein binding ; ATP binding ; estrogen receptor binding ;
Cellular component	cytoplasm ; COP9 signalosome ; nucleus ; fibrillar center ; Cul4-RING E3 ubiquitin ligase complex ;
Biological process	regulation of transcription, DNA-templated ; phosphorylation ; negative regulation of transcription by RNA polymerase II ; transcription, DNA-templated ; cell competition in a multicellular organism ; protein ubiquitination ; V(D)J recombination ; B cell differentiation ; viral process ; chromatin organization ;
	Sources:Amigo / QuickGO
Orthologs
	9730
	321006
	ENSG00000145041
	ENSMUSG00000040325
	Q9Y4B6
	Q80TR8
NM_001171904 ; NM_014703 ; NM_001349168 ; NM_001349169 ; NM_001349170 ;
	NM_001349171 ; NM_001387578 ; NM_001387579 ; NM_001387580 ; NM_001387581 ; NM_001387582 ; NM_001387583 Contents Interactions ; References ; Further reading ;
	NM_001015507 ; NM_001373930 ; NM_001373931
NP_001165375 ; NP_055518 ; NP_001336097 ; NP_001336098 ; NP_001336099 ;
	NP_001336100
	NP_001015507 ; NP_001360859 ; NP_001360860
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^[5]^[6]^[7]

Interactions

VPRBP has been shown to interact with Merlin.^[8]

Related Research Articles

Merlin is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in neurofibromatosis type II. Sequence data reveal its similarity to the ERM protein family.

WEE1 homolog , also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.

NEDD8 is a protein that in humans is encoded by the NEDD8 gene. This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The primary known substrates of NEDD8 modification are the cullin subunits of cullin-based E3 ubiquitin ligases, which are active only when NEDDylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.

COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.

Cullin-4A is a protein that in humans is encoded by the CUL4A gene. CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. A component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.

DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Cullin-5 is a protein that in humans is encoded by the CUL5 gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's Syndrome.

Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.

Vpr is a Human immunodeficiency virus gene and protein product.

DDB1 and CUL4 associated factor 17 is a protein that in humans is encoded buy the DCAF17 gene.

DDB1 and CUL4 associated factor 8 is a protein that in humans is encoded by the DCAF8 gene.

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene.

DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145041 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040325 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhao LJ, Mukherjee S, Narayan O (June 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577–82. doi: 10.1016/S0021-9258(17)40719-8 . PMID 8195203.
↑ Zhang S, Feng Y, Narayan O, Zhao LJ (January 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
↑ "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
↑ Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi: 10.1038/onc.2008.44 . PMID 18332868.

Tan L, Ehrlich E, Yu XF (October 2007). "DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest". Journal of Virology. 81 (19): 10822–30. doi:10.1128/JVI.01380-07. PMC 2045451 . PMID 17626091.
Wen X, Duus KM, Friedrich TD, de Noronha CM (September 2007). "The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor". The Journal of Biological Chemistry. 282 (37): 27046–57. doi: 10.1074/jbc.M703955200 . PMID 17620334.
Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J (July 2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11778–83. Bibcode:2007PNAS..10411778H. doi: 10.1073/pnas.0702102104 . PMC 1906728 . PMID 17609381.
Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F (January 2007). "HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase". Cell Cycle. 6 (2): 182–8. doi: 10.4161/cc.6.2.3732 . PMID 17314515.
Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Brière JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E (March 2007). "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells". Cell Death and Differentiation. 14 (3): 422–35. doi: 10.1038/sj.cdd.4402018 . PMID 16888644.
Zhao LJ, Zhang S, Chinnadurai G (2002). "Sox9 transactivation and testicular expression of a novel human gene, KIAA0800". Journal of Cellular Biochemistry. 86 (2): 277–89. doi:10.1002/jcb.10214. PMID 12111997. S2CID 36090208.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145041 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040325 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8195203-5] Zhao LJ, Mukherjee S, Narayan O (June 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577–82. doi: 10.1016/S0021-9258(17)40719-8 . PMID 8195203.

[pmid11223251-6] Zhang S, Feng Y, Narayan O, Zhao LJ (January 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.

[entrez-7] "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".

[pmid18332868-8] Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi: 10.1038/onc.2008.44 . PMID 18332868.

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VPRBP

Contents

Interactions

Related Research Articles

References

Further reading