Vacuolar protein sorting 37 homolog A (S. cerevisiae) is a protein in humans that is encoded by the VPS37A gene. [5] It is a member of the endosomal sorting complex required for transport (ESCRT) system. [6]
Vacuolar protein sorting 37 homolog A (S. cerevisiae) is a protein in humans that is encoded by the VPS37A gene. [5] It is a member of the endosomal sorting complex required for transport (ESCRT) system. [6]
A missense mutation (K382N) in VPS37A protein has been shown to cause complex hereditary spastic paraparesis (cHSP). [7]
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).
Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.
Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.
Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.
Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.
Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.
Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.
Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.
Charged multivesicular body protein 6 is a protein that in humans is encoded by the CHMP6 gene.
Charged multivesicular body protein 1a is a protein that in humans is encoded by the CHMP1A gene.
Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.
Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.
Charged multivesicular body protein 1b is a protein that in humans is encoded by the CHMP1B gene.
Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.
Vacuolar protein sorting-associated protein 72 homolog is a protein that in humans is encoded by the VPS72 gene.
Vacuolar protein sorting-associated protein 33A is a protein that in humans is encoded by the VPS33A gene.
Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.
The endosomal sorting complexes required for transport (ESCRT) machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes bending/budding away from the cytoplasm. These ESCRT components have been isolated and studied in a number of organisms including yeast and humans. An eukaryotic signature protein, the machinery is found in all eukaryotes and some archaea.
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