VU6028418

Last updated

VU6028418
VU6028418.svg
Identifiers
  • (3aS,6aR)-2-(oxan-4-ylmethyl)-N-[6-(2,3,5-trifluorophenyl)pyridazin-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-amine
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C23H27F3N4O
Molar mass 432.491 g·mol−1
3D model (JSmol)
  • C1COCCC1CN2C[C@H]3CC(C[C@H]3C2)NC4=NN=C(C=C4)C5=C(C(=CC(=C5)F)F)F
  • InChI=1S/C23H27F3N4O/c24-17-9-19(23(26)20(25)10-17)21-1-2-22(29-28-21)27-18-7-15-12-30(13-16(15)8-18)11-14-3-5-31-6-4-14/h1-2,9-10,14-16,18H,3-8,11-13H2,(H,27,29)/t15-,16+,18?
  • Key:ITSKPCHXUYILTR-BYICEURKSA-N

VU6028418 is an experimental drug that acts as a potent and selective antagonist of the Muscarinic acetylcholine receptor M4. It has been investigated for the treatment of dystonia and other movement disorders. [1]

References

  1. ↑ Spock M, Carter TR, Bollinger KA, Han C, Baker LA, Rodriguez AL, et al. (August 2021). "Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist". ACS Medicinal Chemistry Letters. 12 (8): 1342–1349. doi:10.1021/acsmedchemlett.1c00363. PMC   8366002 . PMID   34413964.
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