Vestigial like family member 4

VGLL4
Identifiers
Aliases	VGLL4 , VGL-4, vestigial like family member 4
External IDs	MGI: 2652840 HomoloGene: 18603 GeneCards: VGLL4
Gene location (Human)
Chr.	Chromosome 3 (human)
End	11,771,350 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	114,946,955 bp
RNA expression pattern
	Top expressed in
	tibia; ; nipple; ; trigeminal ganglion; ; pylorus; ; retinal pigment epithelium; ; renal medulla; ; spinal ganglia; ; trachea; ; saphenous vein; ; bronchial epithelial cell;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; lip; ; utricle; ; left lobe of liver; ; yolk sac; ; conjunctival fornix; ; neural tube; ; iris; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; transcription coactivator binding ;
Cellular component	nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; negative regulation of transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	9686
	232334
	ENSG00000144560
	ENSMUSG00000030315
	Q14135
	Q80V24
NM_001128219 ; NM_001128220 ; NM_001128221 ; NM_001284390 ; NM_001284391 ;
	NM_014667
	NM_177683 ; NM_001356371
NP_001121691 ; NP_001121692 ; NP_001121693 ; NP_001271319 ; NP_001271320 ;
	NP_055482
	NP_808351 ; NP_001343300
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Vestigial like family member 4 is a protein that in humans is encoded by the VGLL4 gene. ^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144560 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030315 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Vestigial like family member 4" . Retrieved 2018-05-23.

Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi: 10.1074/jbc.M400154200 . PMID 15140898.
Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi: 10.1074/jbc.M400154200 . PMID 15140898.
Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi: 10.1074/jbc.M400154200 . PMID 15140898.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (December 2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Jin HS, Park HS, Shin JH, Kim DH, Jun SH, Lee CJ, Lee TH (September 2011). "A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration". Biochem. Biophys. Res. Commun. 412 (3): 454–9. doi:10.1016/j.bbrc.2011.07.117. PMID 21839727.
Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA (December 2013). "Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells". Stem Cells. 31 (12): 2833–41. doi:10.1002/stem.1445. PMC 4617635 . PMID 23765749.
Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z, Zhang L, Ji H (March 2014). "VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex". Cell Res. 24 (3): 331–43. doi:10.1038/cr.2014.10. PMC 3945886 . PMID 24458094.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144560 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030315 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Vestigial like family member 4" . Retrieved 2018-05-23.

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Vestigial like family member 4

Related Research Articles

References

Further reading