Vladimir Baranov

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Vladimir Baranov Scientist

Vladimir Baranov is a Soviet born Canadian scientist and one of the original co-inventors of Mass cytometry technology... [1]

Contents

He co-founded DVS Sciences [2] in 2004 (acquired by Fluidigm in 2014 and then renamed to Standard BioTools in 2022 [3] ) along with Dmitry Bandura,Scott D. Tanner and Olga Ornatsky.

Biography

In 1993, he immigrated to Canada. Prior to the formation of DVS Sciences. Dr. Baranov, a Senior Scientist at MDS SCIEX, was a key member of the research team that developed and promoted the Dynamic Reaction Cell®, which remains today at the pinnacle of quadrupole ICP-MS technology.

In 2005, together with Scott D. Tanner and Dmitry Bandura, he began independently developing an ICP-TOF-MS based cytometer and became a researcher at the University of Toronto in March 2005. [4] After securing ample funding by 2010 from various sources, including National Institutes of Health, Ontario Institute for Cancer Research (OICR), the Ministry of Research and Innovation, Ontario Centres of Excellence, Health Technology Exchange, and Genome Canada via the Ontario Genomics Institute, [5] [6] [7] and venture capital from 5 AM Ventures, [8] Vladimir and the DVS Sciences team successfully commercialized their technology, leading to the acquisition of DVS Sciences by Fluidigm in 2014 [9]

Dr. Baranov was a Principal Scientist at DVS Sciences (and then Fluidigm) developing instrumental concepts and algorithmics that advance the CyTOF® line of products. He also and played a fundamental role in the development of the MaxPar line of metal-labeling reagents until his retirement in 2019.

Education

Career

Research

Awards and honors

Publications

A more complete listing of his publications can be found on Google Scholar

Related Research Articles

<span class="mw-page-title-main">Inductively coupled plasma mass spectrometry</span> Type of mass spectrometry that uses an inductively coupled plasma to ionize the sample

Inductively coupled plasma mass spectrometry (ICP-MS) is a type of mass spectrometry that uses an inductively coupled plasma to ionize the sample. It atomizes the sample and creates atomic and small polyatomic ions, which are then detected. It is known and used for its ability to detect metals and several non-metals in liquid samples at very low concentrations. It can detect different isotopes of the same element, which makes it a versatile tool in isotopic labeling.

<span class="mw-page-title-main">Mass spectrometry</span> Analytical technique based on determining mass to charge ratio of ions

Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.

<span class="mw-page-title-main">Environmental chemistry</span> Scientific study of the chemical and phenomena that occur in natural places

Environmental chemistry is the scientific study of the chemical and biochemical phenomena that occur in natural places. It should not be confused with green chemistry, which seeks to reduce potential pollution at its source. It can be defined as the study of the sources, reactions, transport, effects, and fates of chemical species in the air, soil, and water environments; and the effect of human activity and biological activity on these. Environmental chemistry is an interdisciplinary science that includes atmospheric, aquatic and soil chemistry, as well as heavily relying on analytical chemistry and being related to environmental and other areas of science.

Gold fingerprinting is a method of identifying an item made of gold based on the impurities or trace elements it contains.

<span class="mw-page-title-main">Inductively coupled plasma</span> Type of plasma source

An inductively coupled plasma (ICP) or transformer coupled plasma (TCP) is a type of plasma source in which the energy is supplied by electric currents which are produced by electromagnetic induction, that is, by time-varying magnetic fields.

<span class="mw-page-title-main">Inductively coupled plasma atomic emission spectroscopy</span> Analytic scientific technique

Inductively coupled plasma atomic emission spectroscopy (ICP-AES), also referred to as inductively coupled plasma optical emission spectroscopy (ICP-OES), is an analytical technique used for the detection of chemical elements. It is a type of emission spectroscopy that uses the inductively coupled plasma to produce excited atoms and ions that emit electromagnetic radiation at wavelengths characteristic of a particular element. The plasma is a high temperature source of ionised source gas. The plasma is sustained and maintained by inductive coupling from electrical coils at megahertz frequencies. The source temperature is in the range from 6000 to 10,000 K. The intensity of the emissions from various wavelengths of light are proportional to the concentrations of the elements within the sample.

In a chemical analysis, the internal standard method involves adding the same amount of a chemical substance to each sample and calibration solution. The internal standard responds proportionally to changes in the analyte and provides a similar, but not identical, measurement signal. It must also be absent from the sample matrix to ensure there is no other source of the internal standard present. Taking the ratio of analyte signal to internal standard signal and plotting it against the analyte concentrations in the calibration solutions will result in a calibration curve. The calibration curve can then be used to calculate the analyte concentration in an unknown sample.

Velmer A. Fassel was an American chemist who developed the inductively coupled plasma (ICP) and demonstrated its use as ion source for mass spectrometry.

<span class="mw-page-title-main">Ion-mobility spectrometry–mass spectrometry</span>

Ion mobility spectrometry–mass spectrometry (IMS-MS) is an analytical chemistry method that separates gas phase ions based on their interaction with a collision gas and their masses. In the first step, the ions are separated according to their mobility through a buffer gas on a millisecond timescale using an ion mobility spectrometer. The separated ions are then introduced into a mass analyzer in a second step where their mass-to-charge ratios can be determined on a microsecond timescale. The effective separation of analytes achieved with this method makes it widely applicable in the analysis of complex samples such as in proteomics and metabolomics.

<span class="mw-page-title-main">Triple quadrupole mass spectrometer</span> Type of mass spectrometer

A triple quadrupole mass spectrometer (TQMS), is a tandem mass spectrometer consisting of two quadrupole mass analyzers in series, with a (non-mass-resolving) radio frequency (RF)–only quadrupole between them to act as a cell for collision-induced dissociation. This configuration is often abbreviated QqQ, here Q1q2Q3.

A collision/reaction cell is a device used in inductively coupled plasma mass spectrometry to remove interfering ions through ion/neutral reactions.

<span class="mw-page-title-main">CyTOF</span>

Cytometry by time of flight, or CyTOF, is an application of mass cytometry used to quantify labeled targets on the surface and interior of single cells. CyTOF allows the quantification of multiple cellular components simultaneously using an ICP-MS detector.

<span class="mw-page-title-main">Mass cytometry</span> Laboratory technique

Mass cytometry is a mass spectrometry technique based on inductively coupled plasma mass spectrometry and time of flight mass spectrometry used for the determination of the properties of cells (cytometry). In this approach, antibodies are conjugated with isotopically pure elements, and these antibodies are used to label cellular proteins. Cells are nebulized and sent through an argon plasma, which ionizes the metal-conjugated antibodies. The metal signals are then analyzed by a time-of-flight mass spectrometer. The approach overcomes limitations of spectral overlap in flow cytometry by utilizing discrete isotopes as a reporter system instead of traditional fluorophores which have broad emission spectra.

SCIEX is a manufacturer of mass spectrometry instrumentation used in biomedical and environmental applications. Originally started by scientists from the University of Toronto Institute for Aerospace Studies, it is now part of Danaher Corporation with the SCIExe R&D division still located in Toronto, Canada.

<span class="mw-page-title-main">Dmitry Bandura</span> Canadian Scientist, Co-inventor of Mass Cytometry technology

Dmitry Bandura is a Soviet-born Canadian scientist, notable for being one of the co-inventors of the Mass cytometry technology. Bandura co-founded DVS Sciences in 2004 along with Drs Vladimir Baranov, Scott D. Tanner, and Olga Ornatsky.

<span class="mw-page-title-main">Scott D. Tanner</span> Canadian scientist

Scott Tanner is a Canadian scientist, inventor, and entrepreneur. His areas of expertise include mass spectroscopy, especially inductively coupled plasma mass spectrometry (ICP-MS), and mass cytometry.

<span class="mw-page-title-main">Olga Ornatsky</span> Canadian Scientist

Olga Ornatsky is a Soviet born, Canadian scientist. Ornatsky co-founded DVS Sciences in 2004 along with Dmitry Bandura, Vladimir Baranov and Scott D. Tanner.

References

  1. "US Patent 7,135,296". Google Patents. 2000-12-28. Retrieved 6 December 2022.
  2. "Co-Founded DVS Sciences". MaRSdd.com. 2011.
  3. "Fluidigm Renamed to Stanard BioTools". Globenewswirel (Press release). 2022-04-04. Retrieved 9 December 2022.
  4. 1 2 "Vladimir Baranov at the University of Toronto". Sunshine List Stats. Retrieved 20 Aug 2023.
  5. Fong, Tony (May 21, 2010). "Univ. of Toronto Spinout Rolls Out New Biomarker System with Eye on Bead Array Market". Genome Web. Retrieved 29 March 2023.
  6. OICR (2009). "OICR Annual Report 2008/09" (PDF).
  7. "Co-Founder of DVS Sciences". MaRSdd.com. 2011.
  8. "DVS Sciences Raises $14.6 Million in Series A Financing to Advance Commercialization of Novel Single-Cell Analysis Technology" (PDF). 5amventures.
  9. Bunting, Michaeline (January 29, 2014). "Fluidigm To Acquire DVS Sciences". Standard BioTools. Retrieved 29 March 2023.
  10. 1 2 3 4 5 "Vladimir Baranov Biography". 2009. Archived from the original on 2009-06-19.
  11. "Principal Scientist - DVS Sciences". 2014. Archived from the original on 2014-02-28.
  12. Scott D. Tanner; Vladimir Baranov; Dmitry Bandura (2002). "Reaction cells and collision cells for ICP-MS: a tutorial review". Spectrochimica Acta B . 57 (9): 1361–1452. Bibcode:2002AcSpe..57.1361T. doi:10.1016/S0584-8547(02)00069-1.
  13. "HUPO Awards - 2019 RECIPIENTS". HUPO. 2019.
  14. "CyTOF Inventors Receive Prestigious Science and Technology Award from the Human Proteome Organization (HUPO)". Bloomberg.com. Bloomberg. September 18, 2019.
  15. Nicolò Omenetto; Greet de Loos (20 September 2004). "Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2002" . Spectrochimica Acta Part B: Atomic Spectroscopy. 59 (9): 1335. Bibcode:2004AcSpe..59.1335O. doi:10.1016/j.sab.2004.08.002. ISSN   0584-8547.
  16. "Manning Awards - Award of Distinction". Manningawards. 2001. Archived from the original on 2016-08-17.
  17. Gwyn Morgan (Feb 8, 2010). "Manning Award laureates on the cutting edge". TheGlobeAndMail.com. The Globe and Mail. Archived from the original on 2014-02-14.
  18. "1999 Pittcon Editors' Awards". OOcities.org. May 1999.
  19. Qing Chang; Olga I. Ornatsky; Iram Siddiqui; Alexander Loboda; Vladimir I. Baranov; David W. Hedley (September 2017). "Imaging Mass Cytometry". Cytometry Part A. 91 (2): 160–169. doi: 10.1002/cyto.a.23053 . PMID   28160444. S2CID   29523347.
  20. Olg Ornatsky; Dmitry Bandura; Vladimir Baranov; Mark Nitz; Mitchell A Winnik; Scott D.Tanner (September 2010). "Highly Multiparametric Analysis by Mass Cytometry". Journal of Immunological Methods. 361 (1–2). Elsevier: 1–20. doi:10.1016/j.jim.2010.07.002. PMID   20655312.
  21. Dmitry R Bandura; Vladimir Baranov; Olga Ornatsky; Alexei Antonov; Robert Kinach; Xudong Lou; Serguei Pavlov; Sergey Vorobiev; John E Dick; Scott D. Tanner (July 2009). "Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay based on Inductively Coupled Plasma Time-Of-Flight Mass Spectrometry". Analytical Chemistry. 81 (16). American Chemical Society: 6813–6822. doi:10.1021/ac901049w. PMID   19601617.
  22. Xudong Lou; Guohua Zhang; Isaac Herrera; Robert Kinach; Olga Ornatsky; Vladimir Baranov; Mark Nitz; Mitchell Winnik (August 2007). "Polymer-Based Elemental Tags for Sensitive Bioassays". Angewandte Chemie International Edition. 46 (32). WILEY-VCH Verlag Weinheim: 6111–6114. doi:10.1002/anie.200700796. PMC   2504858 . PMID   17533637.
  23. Scott D. Tanner; Vladimir I. Baranov; Dmitry R. Bandura (September 2002). "Reaction Cells and Collision Cells for ICP-MS: a tutorial review". Spectrochimica Acta Part B: Atomic Spectroscopy. 57 (9). Elsevier: 1361–1452. Bibcode:2002AcSpe..57.1361T. doi:10.1016/S0584-8547(02)00069-1.
  24. Vladimir Baranov; Zoe Quinn; Dmitry R. Bandura; Scott D. Tanner (May 2002). "A Sensitive and Quantitative Element-Tagged Immunoassay with ICPMS Detection". Analytical Chemistry. 74 (7). American Chemical Society: 1629–1636. doi:10.1021/ac0110350. PMID   12033255.
  25. Dmitry R. Bandura; Vladimir I. Baranov; Scott D. Tanner (February 2002). "Detection of Ultratrace Phosphorus and Sulfur by Quadrupole ICPMS with Dynamic Reaction Cell" . Analytical Chemistry. 74 (7). ACS Publications: 1497–1502. doi:10.1021/ac011031v. PMID   12033236.
  26. Dmitry R. Bandura; Vladimir I. Baranov; Scott D. Tanner (July 2001). "Reaction Chemistry and Collisional Processes in Multipole Devices for Resolving Isobaric Interferences in ICP–MS" . Fresenius' Journal of Analytical Chemistry. 370 (5). Springer-Verlag: 454–470. doi:10.1007/s002160100869. PMID   11496972. S2CID   20007527.
  27. Scott D. Tanner; Vladimir I. Baranov; Uwe Vollkopf (January 2000). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part III. Optimization and Analytical Performance". Journal of Analytical Atomic Spectrometry. 15 (9). Royal Society of Chemistry: 1261–1269. doi:10.1039/b002604m.
  28. Scott D. Tanner; Vladimir I. Baranov (November 1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part II. Reduction of Interferences Produced within the Cell" . Journal of the American Society for Mass Spectrometry. 10 (11). Springer-Verlag New York: 1083–1094. doi:10.1016/S1044-0305(99)00081-1. S2CID   93608392.
  29. Scott D. Tanner; Vladimir I. Baranov (March 1999). "Theory, Design, and Operation of a Dynamic Reaction Cell for ICP-MS". Atomic Spectroscopy - Norwalk Connecticut. 20. Atomic Spectroscopy: 45–52.
  30. Detlef Schröder; Helmut Schwarz; David E. Clemmer; Yumin Chen; P.B. Armentrout; Vladimir I. Baranov; Diethard K. Böhme (Feb 1997). "Activation of Hydrogen and Methane by Thermalized FeO+ in the Gas Phase as Studied by Multiple Mass Spectrometric Techniques". International Journal of Mass Spectrometry and Ion Processes. 161 (1–3). Elsevier: 175–191. Bibcode:1997IJMSI.161..175S. doi:10.1016/S0168-1176(96)04428-X.