Scott D. Tanner

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Scott D. Tanner Scientist

Scott Tanner is a Canadian scientist, inventor, [1] [2] and entrepreneur. [3] His areas of expertise include mass spectroscopy, especially inductively coupled plasma mass spectrometry (ICP-MS), and mass cytometry.

Contents

Scott is best known for his work on the fundamentals of Inductively Coupled Plasma Mass Spectrometry, [4] for the invention of mass cytometry, [5] and co-founding (with Dmitry Bandura, Vladimir Baranov and Olga Ornatsky) DVS Sciences [3] in 2004,(acquired by Fluidigm in 2014 and then renamed to Standard BioTools in 2022 [6] ) the company that first commercialized the instrument and reagents of mass cytometry.

Early life and education

Scott was born and raised in St. Catharines, Ontario Canada. He bought his first chemistry set, from his brother, at age 6. [7] [8] Through his early teenage years, he was provided with laboratory space at Brock University, under the guidance of Dr. E.A. Cherniak and Dr. F.P. Koffyberg, where he attempted to replicate Geiger–Marsden experiments also known as Rutherford’s experiment (scattering of alpha particles by gold foil) using various home-built instruments, including cloud chambers. [7] [8]

Scott graduated with a BSC in Chemistry from York University in 1976. During his undergraduate years, he became a nationally ranked gymnast. [7] [8] [9] An injury at the Olympic trials ended his competitive gymnastics career, and he took up marathon running during graduate school (best time 2:47:13). [7] [8] He received a Doctor of Philosophy (Chemistry) from York University in 1980, having studied ion-molecule reaction kinetics and flame ion chemistry with Drs. D.K Bohme and J.M. Goodings. [7] [8]

Biography

Dr. Tanner joined SCIEX, which later became MDS SCIEX, in 1980 as a research scientist. He became Principal Scientist in 2000. In his 25 years at SCIEX, Dr. Tanner developed and helped to commercialize a string of Mass Spectrometry products.

Scott published over 74 peer-reviewed scientific articles, and holds 22 US patents [10] (with corresponding filings in other countries), including 13 patents on Mass Cytometry technology

Scott was a co-founder of DVS Sciences and, as the President and CEO, saw the company through the development and commercial launch of its first products.

The products that DVS Sciences brought to the global market were originally developed at the University of Toronto where Dr. Tanner was a Professor in the Institute of Biomaterials and Biomedical Engineering and then in Chemistry.

Career

Volunteer Work

Chair of the Three Churches Heritage Foundation in Mahone Bay - 2020-Present [12] [13]

Books

Research

Awards and honors

Publications

Scott has published more than 75 peer-reviewed articles.
The 13 most cited (more than 200 citations each) include:

A more complete listing of his publications can be found on Google Scholar

Related Research Articles

<span class="mw-page-title-main">Inductively coupled plasma mass spectrometry</span> Type of mass spectrometry that uses an inductively coupled plasma to ionize the sample

Inductively coupled plasma mass spectrometry (ICP-MS) is a type of mass spectrometry that uses an inductively coupled plasma to ionize the sample. It atomizes the sample and creates atomic and small polyatomic ions, which are then detected. It is known and used for its ability to detect metals and several non-metals in liquid samples at very low concentrations. It can detect different isotopes of the same element, which makes it a versatile tool in isotopic labeling.

In physics, atomic spectroscopy is the study of the electromagnetic radiation absorbed and emitted by atoms. Since unique elements have unique emission spectra, atomic spectroscopy is applied for determination of elemental compositions. It can be divided by atomization source or by the type of spectroscopy used. In the latter case, the main division is between optical and mass spectrometry. Mass spectrometry generally gives significantly better analytical performance, but is also significantly more complex. This complexity translates into higher purchase costs, higher operational costs, more operator training, and a greater number of components that can potentially fail. Because optical spectroscopy is often less expensive and has performance adequate for many tasks, it is far more common. Atomic absorption spectrometers are one of the most commonly sold and used analytical devices.

<span class="mw-page-title-main">Environmental chemistry</span> Scientific study of the chemical and phenomena that occur in natural places

Environmental chemistry is the scientific study of the chemical and biochemical phenomena that occur in natural places. It should not be confused with green chemistry, which seeks to reduce potential pollution at its source. It can be defined as the study of the sources, reactions, transport, effects, and fates of chemical species in the air, soil, and water environments; and the effect of human activity and biological activity on these. Environmental chemistry is an interdisciplinary science that includes atmospheric, aquatic and soil chemistry, as well as heavily relying on analytical chemistry and being related to environmental and other areas of science.

Gold fingerprinting is a method used to identify and authenticate gold items by analyzing the unique composition of impurities or trace elements within the metal. While gold itself is an inert and relatively uniform element, gold found in natural or processed items often contains small amounts of other elements, such as silver or lead. These trace elements, which vary depending on the source and refining process, serve as a "fingerprint" for the gold. By comparing the elemental composition of a gold sample to databases of known sources, experts can determine where the gold was likely mined or processed. This technique is applied in fields such as archaeology, geology, and forensic science, as it provides insights into the provenance of historical artifacts, mined gold, or stolen items.

<span class="mw-page-title-main">Inductively coupled plasma</span> Type of plasma source

An inductively coupled plasma (ICP) or transformer coupled plasma (TCP) is a type of plasma source in which the energy is supplied by electric currents which are produced by electromagnetic induction, that is, by time-varying magnetic fields.

<span class="mw-page-title-main">Inductively coupled plasma atomic emission spectroscopy</span> Analytic scientific technique

Inductively coupled plasma atomic emission spectroscopy (ICP-AES), also referred to as inductively coupled plasma optical emission spectroscopy (ICP-OES), is an analytical technique used for the detection of chemical elements. It is a type of emission spectroscopy that uses the inductively coupled plasma to produce excited atoms and ions that emit electromagnetic radiation at wavelengths characteristic of a particular element. The plasma is a high temperature source of ionised source gas. The plasma is sustained and maintained by inductive coupling from electrical coils at megahertz frequencies. The source temperature is in the range from 6000 to 10,000 K. The intensity of the emissions from various wavelengths of light are proportional to the concentrations of the elements within the sample.

In a chemical analysis, the internal standard method involves adding the same amount of a chemical substance to each sample and calibration solution. The internal standard responds proportionally to changes in the analyte and provides a similar, but not identical, measurement signal. It must also be absent from the sample matrix to ensure there is no other source of the internal standard present. Taking the ratio of analyte signal to internal standard signal and plotting it against the analyte concentrations in the calibration solutions will result in a calibration curve. The calibration curve can then be used to calculate the analyte concentration in an unknown sample.

Velmer A. Fassel was an American chemist who developed the inductively coupled plasma (ICP) and demonstrated its use as ion source for mass spectrometry.

<span class="mw-page-title-main">Atomic emission spectroscopy</span> Analytical method using radiation to identify chemical elements in a sample

Atomic emission spectroscopy (AES) is a method of chemical analysis that uses the intensity of light emitted from a flame, plasma, arc, or spark at a particular wavelength to determine the quantity of an element in a sample. The wavelength of the atomic spectral line in the emission spectrum gives the identity of the element while the intensity of the emitted light is proportional to the number of atoms of the element. The sample may be excited by various methods.

A collision/reaction cell is a device used in inductively coupled plasma mass spectrometry to remove interfering ions through ion/neutral reactions.

Pittcon Editors’ Awards honoured the best new products on show at the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, or Pittcon, for 20 years from 1996 having been established by Dr Gordon Wilkinson, managing editor of Analytical Instrument Industry Report. On 8 March 2015, the event returned to the Morial Convention Center in New Orleans and this was the last occasion when the awards were presented.

<span class="mw-page-title-main">CyTOF</span>

Cytometry by time of flight, or CyTOF, is an application of mass cytometry used to quantify labeled targets on the surface and interior of single cells. CyTOF allows the quantification of multiple cellular components simultaneously using an ICP-MS detector.

<span class="mw-page-title-main">Mass cytometry</span> Laboratory technique

Mass cytometry is a mass spectrometry technique based on inductively coupled plasma mass spectrometry and time of flight mass spectrometry used for the determination of the properties of cells (cytometry). In this approach, antibodies are conjugated with isotopically pure elements, and these antibodies are used to label cellular proteins. Cells are nebulized and sent through an argon plasma, which ionizes the metal-conjugated antibodies. The metal signals are then analyzed by a time-of-flight mass spectrometer. The approach overcomes limitations of spectral overlap in flow cytometry by utilizing discrete isotopes as a reporter system instead of traditional fluorophores which have broad emission spectra.

SCIEX is a manufacturer of mass spectrometry instrumentation used in biomedical and environmental applications. Originally started by scientists from the University of Toronto Institute for Aerospace Studies, it is now part of Danaher Corporation with the SCIExe R&D division still located in Toronto, Canada.

<span class="mw-page-title-main">Dmitry Bandura</span> Canadian Scientist, Co-inventor of Mass Cytometry technology

Dmitry Bandura is a Soviet-born Canadian scientist, notable for being one of the co-inventors of the Mass cytometry technology. Bandura co-founded DVS Sciences in 2004 along with Drs Vladimir Baranov, Scott D. Tanner, and Olga Ornatsky.

<span class="mw-page-title-main">Vladimir Baranov</span> Soviet-born Canadian scientist

Vladimir Baranov is a Soviet born Canadian scientist and one of the original co-inventors of Mass cytometry technology...

<span class="mw-page-title-main">Olga Ornatsky</span> Canadian Scientist

Olga Ornatsky is a Soviet born, Canadian scientist. Ornatsky co-founded DVS Sciences in 2004 along with Dmitry Bandura, Vladimir Baranov and Scott D. Tanner.

References

  1. "Patents by Inventor Scott D. Tanner". Justia.com.
  2. "Scott D. Taner Inventions". Patentguru.com.
  3. 1 2 "Co-Founder of DVS Sciences". MaRSdd.com. 2011.
  4. D. J. Douglas; S.D. Tanner (1998). "Fundamental Considerations in ICP-MS". In Montaser, Akbar (ed.). Inductively Coupled Plasma Mass Spectrometry. New York: Wiley-VCH. pp. 615–679. ISBN   978-0-471-18620-5.
  5. "US Patent 7,135,296". Google Patents. 2000-12-28. Retrieved 6 December 2022.
  6. "Fluidigm Renamed to Stanard BioTools". Globenewswirel. 2022-04-04. Retrieved 9 December 2022.
  7. 1 2 3 4 5 6 "Scott Tanner Biography" (PDF). StemSpecs. Nov 2005. Archived from the original (PDF) on 2009-07-04.
  8. 1 2 3 4 5 Ben Merison (August 6, 2009). "Interview: Raising the Bar". Highlights in Chemical Technology. 2009 (9): T65–T72. Archived from the original on 2012-10-24.
  9. "Atonic Spectrometry Viewpoint: Scott Tanner". Journal of Analytical Atomic Spectrometry. 10 (1). January 1995.
  10. "Scott D. Tanner Patents". Google Patents. Retrieved 6 December 2022.
  11. "President - DVS Sciences". 2009. Archived from the original on 2009-06-19.
  12. 1 2 "Outstanding Achievement". YorkU.ca. 2024-11-06.
  13. "Chair of the Three Churches Heritage Foundation" (PDF). TownofMahoneBay.ca. 2020.
  14. Holland, J. Grenville; Tanner, Scott D., eds. (4 August 2003). Plasma Source Mass Spectrometry: Applications and Emerging Technologies. Royal Society of Chemistry. ISBN   0854046038.
  15. Holland, J. Grenville; Tanner, Scott D., eds. (2001). Plasma Source Mass Spectrometry : The New Millennium. Cambridge: Royal Society of Chemistry. ISBN   0854048952.
  16. Holland, Grenville; Tanner, Scott D. Tanner, eds. (23 July 1999). Plasma Source Mass Spectrometry: New Developments and Applications. Cambridge, UK: Royal Society of Chemistry. ISBN   0854047492.
  17. Holland, Grenville; Tanner, Scott D., eds. (1997). Plasma Source Mass Spectrometry : Developments and Applications. Cambridge: Royal Society of Chemistry. ISBN   0854047271.
  18. T. Sakuma; N. Gurprasad; S.D. Tanner; A. Ngo; W.R. Davidson; H.A. McLeod; B.P-Y Lau; J.J. Ryan (1985). "The Application of Rapid Gas Chromatographic Tandem Mass Spectrometry in the Analysis of Complex Samples for Chlorinated Dioxins and Furans". In Keith, L.H.; Rappe, C.; Choudhary, G. (eds.). Chlorinated Dioxins and Dibenzofurans in the Total Environment II. p. 139. OL   21212149M.
  19. The Instantaneous Detection of Explosives by Tandem Mass Spectrometry, S.D. Tanner, W.R. Davidson and J.E. Fulford. Quantico, Virginia: US Dept of Justice. 1983.
  20. "The Use of a Commercially Available Atmospheric Pressure Chemical Ionization Tandem Quadrupole Mass Spectrometer for the Direct Detection of Chemical Agents and Simulants, B.A. Petersen, S.D. Tanner, J.E. Fulford, B.I. Shushan and W.R. Davidson". Proc.of the 1985 Sci. Conf. On Chem. Defence Research, CRDC-SP-86007. Aberdeen Proving Ground, Maryland: USAAMCC: 15. 1986.
  21. E.R. Denoyer; D. Jacques; E. Debrah; S.D. Tanner (1995). "Determination of Trace Elements in Uranium: Practical Benefits of a New ICP-MS Lens System". Atomic Spectroscopy. 16 (1).
  22. Vladimir I. Baranov; Scott D. Tanner (1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). I. The RF-Field Energy Contribution in Thermodynamics of Ion-Molecule Reactions". Journal of Analytical Atomic Spectrometry. 14 (8): 1133–1142. doi:10.1039/a809889a.
  23. S.D. Tanner; V.I. Baranov (November 1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). II. Reduction of Interferences Produced Within the Cell". Journal of the American Society for Mass Spectrometry. 10 (11): 1083–1094. doi:10.1016/S1044-0305(99)00081-1. S2CID   93608392.
  24. Scott D. Tanner; Vladimir I. Baranov; Uwe Vollkopf (2000). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). III. Analytical Performance". Journal of Analytical Atomic Spectrometry. 9 (15): 1261–1269.
  25. Marcia Kaye (September 13, 2011). "Seeing Into The Soul of Cells". University of Toronto.
  26. "Lifetime Achievement Award in Plasma Spectrochemistry". Spectroscopyonline. 2020-01-13.
  27. "HUPO Awards - 2019 RECIPIENTS". HUPO. 2019.
  28. "CyTOF Inventors Receive Prestigious Science and Technology Award from the Human Proteome Organization (HUPO)". Bloomberg. Bloomberg.com. September 18, 2019.
  29. "AIMBE College of Fellows Class of 2014". AIMBE. 2014.
  30. "U of T's 2011 Inventor of the Year". UToronto. 2011.
  31. Nicolò Omenetto; Greet de Loos (20 September 2004). "Elsevier/Spectrochimica Acta Atomic Spectroscopy Award 2002". Spectrochimica Acta Part B: Atomic Spectroscopy. 59 (9): 1335. Bibcode:2004AcSpe..59.1335O. doi:10.1016/j.sab.2004.08.002. ISSN   0584-8547.
  32. "Manning Awards - Award of Distinction". Manningawards. 2001. Archived from the original on 2016-08-17.
  33. Gwyn Morgan (Feb 8, 2010). "Manning Award laureates on the cutting edge". TheGlobeAndMail.com. The Globe and Mail. Archived from the original on 2014-02-14.
  34. "1999 Pittcon Editors' Awards". OOcities.org. May 1999.
  35. "Fellow of the Royal Society of Chemistry". RSC.org.
  36. "Fellow of the American Institute for Medical and Biological Engineering". AIMBE.org. 2014.
  37. Sean C. Bendall; Erin F. Simonds; Peng Qiu; El-ad D. Amir; Peter O. Krutzik; Rachel Finck; Robert V. Bruggner; Rachel Melamed; Angelica Trejo; Olga I. Ornatsky; Robert S. Balderas; Sylvia K. Plevritis; Karen Sachs; Dana Pe’er; Scott D. Tanner; Garry P. Nolan (May 2011). "Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum". Science. 332 (6030). American Association for the Advancement of Science: 6813–6822. Bibcode:2011Sci...332..687B. doi:10.1126/science.1198704. PMC   3273988 . PMID   21551058.
  38. Olga Ornatsky; Dmitry Bandura; Vladimir Baranov; Mark Nitz; Mitchell A Winnik; Scott Tanner (September 2010). "Highly Multiparametric Analysis by Mass Cytometry". Journal of Immunological Methods. 361 (1–2). Elsevier: 1–20. doi:10.1016/j.jim.2010.07.002. PMID   20655312.
  39. Dmitry R Bandura; Vladimir I Baranov; Olga I Ornatsky; Alexei Antonov; Robert Kinach; Xudong Lou; Serguei Pavlov; Sergey Vorobiev; John E Dick; Scott D Tanner (Aug 2009). "Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-Of-Flight Mass Spectrometry". Analytical Chemistry. 81 (16). American Chemical Society: 6813–6822. doi:10.1021/ac901049w. PMID   19601617.
  40. Scott D. Tanner; Vladimir I. Baranov; Dmitry R. Bandura (September 2002). "Reaction Cells and Collision Cells for ICP-MS: A Tutorial Review". Spectrochimica Acta Part B: Atomic Spectroscopy. 57 (9). Elsevier: 1361–1452. Bibcode:2002AcSpe..57.1361T. doi:10.1016/S0584-8547(02)00069-1.
  41. Vladimir I. Baranov; Zoë Quinn; Dmitry R. Bandura; Scott D. Tanner (April 2002). "A Sensitive and Quantitative Element-Tagged Immunoassay with ICPMS Detection". Analytical Chemistry. 74 (7). American Chemical Society: 1629–1636. doi:10.1021/ac0110350. PMID   12033255.
  42. Dmitry R. Bandura; Vladimir I. Baranov; Scott D. Tanner (April 2002). "Detection of Ultratrace Phosphorus and Sulfur by Quadrupole ICPMS with Dynamic Reaction Cell". Analytical Chemistry. 74 (7). American Chemical Society: 1497–1502. doi:10.1021/ac011031v. PMID   12033236.
  43. Dmitry R. Bandura; Vladimir I. Baranov; Scott D. Tanner (July 2001). "Reaction Chemistry and Collisional Processes in Multipole Devices for Resolving Isobaric Interferences in ICP–MS". Fresenius' Journal of Analytical Chemistry. 370 (5). Springer-Verlag: 454–470. doi:10.1007/s002160100869. PMID   11496972. S2CID   20007527.
  44. Scott D. Tanner; Vladimir I. Baranov; Uwe Vollkopf (August 2000). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part III". Journal of Analytical Atomic Spectrometry. 15 (9). Royal Society of Chemistry: 1261–1269. doi:10.1039/b002604m.
  45. Scott D. Tanner; Vladimir I. Baranov (November 1999). "A Dynamic Reaction Cell for Inductively Coupled Plasma Mass Spectrometry (ICP-DRC-MS). Part II. Reduction of Interferences Produced within the Cell". Journal of the American Society for Mass Spectrometry. 10 (11). Springer-Verlag: 1083–1094. doi:10.1016/S1044-0305(99)00081-1. S2CID   93608392.
  46. Scott D. Tanner; Vladimir I. Baranov (March 1999). "Theory, Design, and Operation of a Dynamic Reaction Cell for ICP-MS". Atomic Spectroscopy - Norwalk Connecticut. 20. Atomic Spectroscopy: 45–52.
  47. Scott D. Tanner (January 1995). "Characterization of Ionization and Matrix Suppression in Inductively Coupled 'Cold' Plasma Mass Spectrometry". Journal of Analytical Atomic Spectrometry. 10 (11). The Royal Society of Chemistry: The Royal Society of Chemistry.
  48. Scott D Tanner (June 1992). "Space Charge in ICP-MS: Calculation and Implications". Spectrochimica Acta Part B: Atomic Spectroscopy. 47 (6). Elsevier: 809–823. Bibcode:1992AcSpe..47..809T. doi:10.1016/0584-8547(92)80076-S.
  49. George R. Gillson; Donald J. Douglas; John E. Fulford; Kenneth W Halligan; Scott D. Tanner (July 1988). "Nonspectroscopic Interelement Interferences in Inductively Coupled Plasma Mass Spectrometry". Analytical Chemistry. 60 (14). American Chemical Society: 1472–1474. doi:10.1021/ac00165a024.