WDR1

Last updated
WDR1
Identifiers
Aliases WDR1 , AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDs OMIM: 604734; MGI: 1337100; HomoloGene: 6628; GeneCards: WDR1; OMA:WDR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005112
NM_017491

NM_011715

RefSeq (protein)

NP_005103
NP_059830

NP_035845

Location (UCSC) Chr 4: 10.07 – 10.12 Mb Chr 5: 38.68 – 38.72 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene. [5] [6]

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000071127 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005103 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID   10036186.
  6. 1 2 "Entrez Gene: WDR1 WD repeat domain 1".

Further reading