WDR1

WDR1
Identifiers
Aliases	WDR1 , AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDs	OMIM: 604734 MGI: 1337100 HomoloGene: 6628 GeneCards: WDR1
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.1 Start 10,074,339 bp [1] End 10,116,949 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 B3|5 20.63 cM Start 38,684,156 bp [2] End 38,720,564 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery smooth muscle tissue right coronary artery saphenous vein stromal cell of endometrium parotid gland thoracic aorta ascending aorta left uterine tube left coronary artery Top expressed in ankle joint corneal stroma mucous cell of stomach left colon molar belly cord dorsomedial hypothalamic nucleus parotid gland ascending aorta atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding actin filament binding Cellular component extracellular region myelin sheath podosome cell junction cell projection extracellular exosome cytoskeleton actin filament cell-cell junction cytoplasm cytosol cortical actin cytoskeleton plasma membrane Biological process platelet degranulation sensory perception of sound actin cytoskeleton organization regulation of ventricular cardiac muscle cell membrane repolarization regulation of oligodendrocyte differentiation maintenance of epithelial cell apical/basal polarity apical junction assembly regulation of actin filament depolymerization neutrophil mediated immunity regulation of cell shape actin filament fragmentation platelet formation positive regulation of actin filament depolymerization cortical cytoskeleton organization locomotion establishment of planar polarity of follicular epithelium sarcomere organization neutrophil migration actin filament depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9948 22388 Ensembl ENSG00000071127 ENSMUSG00000005103 UniProt O75083 O88342 RefSeq (mRNA) NM_005112 NM_017491 NM_011715 RefSeq (protein) NP_005103 NP_059830 NP_035845 Location (UCSC) Chr 4: 10.07 – 10.12 Mb Chr 5: 38.68 – 38.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For the former German radio station, see WDR 1.

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene. ^{[5] [6]}

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000071127 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005103 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID   10036186.
6. "Entrez Gene: WDR1 WD repeat domain 1".

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID   1602151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Rodal AA, Tetreault JW, Lappalainen P, et al. (1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251–64. doi:10.1083/jcb.145.6.1251. PMC   2133144 . PMID   10366597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 supports mitotic cell rounding". Biochem. Biophys. Res. Commun. 327 (1): 268–75. doi:10.1016/j.bbrc.2004.11.156. PMID   15629458.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.