WDR3

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WDR3
Identifiers
Aliases	WDR3 , DIP2, UTP12, WD repeat domain 3
External IDs	OMIM: 604737; MGI: 2443143; HomoloGene: 4937; GeneCards: WDR3; OMA:WDR3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p12 Start 117,929,720 bp [1] End 117,966,543 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 100,045,496 bp [2] End 100,069,723 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium pancreatic ductal cell buccal mucosa cell parietal pleura germinal epithelium islet of Langerhans visceral pleura Epithelium of choroid plexus epithelium of nasopharynx hair follicle Top expressed in primitive streak medullary collecting duct hand condyle epiblast fossa superior cervical ganglion abdominal wall renal corpuscle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function snoRNA binding RNA binding Cellular component Pwp2p-containing subcomplex of 90S preribosome small-subunit processome nuclear membrane nucleolus nucleoplasm nucleus Biological process rRNA processing maturation of SSU-rRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10885 269470 Ensembl ENSG00000065183 ENSMUSG00000033285 UniProt Q9UNX4 Q8BHB4 RefSeq (mRNA) NM_006784 NM_175552 NM_001355657 RefSeq (protein) NP_006775 NP_780761 NP_001342586 Location (UCSC) Chr 1: 117.93 – 117.97 Mb Chr 3: 100.05 – 100.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene. ^{[5] [6]}

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000065183 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033285 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID   10395803.
6. "Entrez Gene: WDR3 WD repeat domain 3".

Further reading

• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy". Genomics. 50 (1): 44–52. doi:10.1006/geno.1998.5308. PMID   9628821.