WDR33

Last updated
WDR33
Identifiers
Aliases WDR33 , NET14, WDC146, WD repeat domain 33
External IDs OMIM: 618082 MGI: 1921570 HomoloGene: 56807 GeneCards: WDR33
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006622
NM_001006623
NM_018383

NM_001170966
NM_001170967
NM_001170970
NM_028866

RefSeq (protein)

NP_001006623
NP_001006624
NP_060853

NP_001164437
NP_001164438
NP_001164441
NP_083142

Location (UCSC) Chr 2: 127.7 – 127.81 Mb Chr 18: 31.94 – 32.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene. [5] [6]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [6]

Related Research Articles

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<span class="mw-page-title-main">WD repeat-containing protein 77</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PAK1IP1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">WDR45</span> Protein-coding gene in humans

WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause a distinct form of Neurodegeneration with brain iron accumulation (NBIA) called Beta-propeller protein-associated neurodegeneration (BPAN).

<span class="mw-page-title-main">INTS8</span> Protein-coding gene in the species Homo sapiens

Integrator complex subunit 8 is a protein that in humans is encoded by the INTS8 gene.

<span class="mw-page-title-main">WDR26</span> Protein-coding gene in the species Homo sapiens

WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.

<span class="mw-page-title-main">WDR47</span> Protein-coding gene in the species Homo sapiens

WD repeat domain 47 is a protein that in humans is encoded by the WDR47 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136709 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024400 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ito S, Sakai A, Nomura T, Miki Y, Ouchida M, Sasaki J, Shimizu K (Feb 2001). "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner". Biochem Biophys Res Commun. 280 (3): 656–63. doi:10.1006/bbrc.2000.4163. PMID   11162572.
  6. 1 2 "Entrez Gene: WDR33 WD repeat domain 33".

Further reading