WDR37 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | WDR37 , WD repeat domain 37, NOCGUS | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 1920393 HomoloGene: 40914 GeneCards: WDR37 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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WD repeat-containing protein 37 is a protein that in humans is encoded by the WDR37 gene. [5] [6] [7]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [7]
Mutations in this gene have been linked to a number of lesions in humans. [8] [9] These include
The Abelson helper integration site 1 (AHI1) is a protein coding gene that is known for the critical role it plays in brain development. Proper cerebellar and cortical development in the human brain depends heavily on AHI1. The AHI1 gene is prominently expressed in the embryonic hindbrain and forebrain. AHI1 specifically encodes the Jouberin protein and mutations in the expression of the gene is known to cause specific forms of Joubert syndrome. Joubert syndrome is autosomal recessive and is characterized by the brain malformations and mental retardation that AHI1 mutations have the potential to induce. AHI1 has also been associated with schizophrenia and autism due to the role it plays in brain development. An AHI1 heterozygous knockout mouse model was studied by Bernard Lerer and his group at Hadassah Medical Center in Jerusalem to elucidate the correlation between alterations in AHI1 expression and the pathogenesis of neuropsychiatric disorders. The core temperatures and corticosterone secretions of the heterozygous knockout mice after exposure to environmental and visceral stress exhibited extreme repression of autonomic nervous system and hypothalamic-pituitary-adrenal responses. The knockout mice demonstrated an increased resilience to different types of stress and these results lead to a correlation between emotional regulation and neuropsychiatric disorders.
Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.
WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.
WD repeat-containing protein 44 is a protein that in humans is encoded by the WDR44 gene.
Alpha-1,2-mannosyltransferase ALG9 is an enzyme that in humans is encoded by the ALG9 gene.
F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.
CGG triplet repeat-binding protein 1 is a protein that in humans is encoded by the CGGBP1 gene.
Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene.
WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.
WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.
Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.
PH domain and leucine rich repeat protein phosphatase-like, also known as PHLPPL, is an enzyme which in humans is encoded by the PHLPPL gene.
Leucine-rich repeat-containing protein 48 is a protein that in humans is encoded by the LRRC48 gene.
WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.
Kelch repeat and BTB domain-containing protein 7 is a protein that in humans is encoded by the KBTBD7 gene.
Integrator complex subunit 7 is a protein that in humans is encoded by the INTS7 gene.
WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.
WD repeat-containing protein 24 is a protein that in humans is encoded by the WDR24 gene.
F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.
WD repeat-containing protein 72 is a protein that in humans is encoded by the WDR72 gene. WDR72 contains 7 WD40 repeats, which are predicted to form the blades of a 7 beta propeller structure.