Integral membrane protein GPR155, also known as G protein-coupled receptor 155, is a protein that in humans is encoded by the GPR155 gene. Mutations in this gene may be associated with autism.
The Abelson helper integration site 1 (AHI1) is a protein coding gene that is known for the critical role it plays in brain development. Proper cerebellar and cortical development in the human brain depends heavily on AHI1. The AHI1 gene is prominently expressed in the embryonic hindbrain and forebrain. AHI1 specifically encodes the Jouberin protein and mutations in the expression of the gene is known to cause specific forms of Joubert syndrome. Joubert syndrome is autosomal recessive and is characterized by the brain malformations and mental retardation that AHI1 mutations have the potential to induce. AHI1 has also been associated with schizophrenia and autism due to the role it plays in brain development. An AHI1 heterozygous knockout mouse model was studied by Bernard Lerer and his group at Hadassah Medical Center in Jerusalem to elucidate the correlation between alterations in AHI1 expression and the pathogenesis of neuropsychiatric disorders. The core temperatures and corticosterone secretions of the heterozygous knockout mice after exposure to environmental and visceral stress exhibited extreme repression of autonomic nervous system and hypothalamic-pituitary-adrenal responses. The knockout mice demonstrated an increased resilience to different types of stress and these results lead to a correlation between emotional regulation and neuropsychiatric disorders.
Myotrophin is a protein that in humans is encoded by the MTPN gene.
Ataxin-10 is a protein that in humans is encoded by the ATXN10 gene.
WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.
WD repeat-containing protein 44 is a protein that in humans is encoded by the WDR44 gene.
Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.
Bardet–Biedl syndrome 5 protein is a protein that in humans is encoded by the BBS5 gene.
CGG triplet repeat-binding protein 1 is a protein that in humans is encoded by the CGGBP1 gene.
Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene.
WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.
Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.
PH domain and leucine rich repeat protein phosphatase-like, also known as PHLPPL, is an enzyme which in humans is encoded by the PHLPPL gene.
SCAN domain-containing protein 3 is a protein that in humans is encoded by the SCAND3 gene.
Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.
Kelch repeat and BTB domain-containing protein 7 is a protein that in humans is encoded by the KBTBD7 gene.
Transmembrane and TPR repeat-containing protein 2 is a protein that in humans is encoded by the TMTC2 gene.
Integrator complex subunit 7 is a protein that in humans is encoded by the INTS7 gene.
Tetratricopeptide repeat protein 25 is a protein that in humans is encoded by the TTC25 gene.
WD repeat-containing protein 24 is a protein that in humans is encoded by the WDR24 gene.
