WDR6

WDR6
Identifiers
Aliases	WDR6 , WD repeat domain 6, Trm734
External IDs	OMIM: 606031 MGI: 1930140 HomoloGene: 117682 GeneCards: WDR6
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,015,953 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,455,938 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix; ; body of pancreas; ; left uterine tube; ; ganglionic eminence; ; stromal cell of endometrium;
	Top expressed in
	arcuate nucleus; ; ventromedial nucleus; ; median eminence; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; mammillary body; ; lateral hypothalamus; ; ventral tegmental area; ; suprachiasmatic nucleus; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; RNA binding ;
Cellular component	cytoplasm ; COP9 signalosome ; cytosol ; plasma membrane ;
Biological process	cell cycle ; negative regulation of autophagy ; negative regulation of cell population proliferation ;
	Sources:Amigo / QuickGO
Orthologs
	11180
	83669
	ENSG00000178252
	ENSMUSG00000066357
	Q9NNW5
	Q99ME2
	NM_018031 ; NM_001320546 ; NM_001320547
	NM_031392
	NP_001307475 ; NP_001307476 ; NP_060501
	NP_113569
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.^[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is ubiquitously expressed in adult and fetal tissues.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178252 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066357 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: WDR6 WD repeat domain 6".

Li D, Roberts R (2002). "WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases". Cell. Mol. Life Sci. 58 (14): 2085–97. doi:10.1007/PL00000838. PMID 11814058. S2CID 20646422.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li D, Burch P, Gonzalez O, et al. (2000). "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene". Biochem. Biophys. Res. Commun. 274 (1): 117–23. doi:10.1006/bbrc.2000.3012. PMID 10903905.
Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. 277 (22): 19439–47. doi: 10.1074/jbc.M111838200 . PMID 11912194.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Xie X, Wang Z, Chen Y (2007). "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction". Mol. Cell. Biochem. 301 (1–2): 115–22. doi:10.1007/s11010-006-9402-5. PMID 17216128. S2CID 25503392.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178252 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066357 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: WDR6 WD repeat domain 6".

[1]

[2]

[3]

[4]

[5]

WDR6

Related Research Articles

References

Further reading