WDR68

DCAF7
Identifiers
Aliases	DCAF7 , AN11, HAN11, SWAN-1, WDR68, DDB1 and CUL4 associated factor 7
External IDs	OMIM: 605973; MGI: 1919083; HomoloGene: 55930; GeneCards: DCAF7; OMA:DCAF7 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse) [1] Band 11|11 E1 Start 105,927,698 bp [1] End 105,950,150 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence oocyte secondary oocyte renal medulla cardia trabecular bone lower lobe of lung ventral tegmental area inferior ganglion of vagus nerve subthalamic nucleus Top expressed in superior cervical ganglion otolith organ utricle hand Paneth cell subiculum trigeminal ganglion anterior amygdaloid area paraventricular nucleus of hypothalamus arcuate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nuclear matrix Cul4-RING E3 ubiquitin ligase complex nucleus cytoplasm cytosol nuclear body nucleoplasm protein-containing complex Biological process multicellular organism development post-translational protein modification protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10238 71833 Ensembl n/a ENSMUSG00000049354 UniProt P61962 P61963 RefSeq (mRNA) NM_001003725 NM_005828 NM_027946 RefSeq (protein) NP_005819 NP_082222 Location (UCSC) n/a Chr 11: 105.93 – 105.95 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 68 is a protein that in humans is encoded by the DCAF7 gene. ^{[4] [5]}

Interactions

WDR68 has been shown to interact with DYRK1A. ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000049354 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. de Vetten N, Quattrocchio F, Mol J, Koes R (Jul 1997). "The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals". Genes Dev. 11 (11): 1422–34. doi: 10.1101/gad.11.11.1422 . PMID   9192870.
5. "Entrez Gene: WDR68 WD repeat domain 68".
6. Skurat AV, Dietrich AD (Jan 2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi: 10.1074/jbc.M301769200 . PMID   14593110.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi: 10.1074/jbc.M301769200 . PMID   14593110.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Morita K, Lo Celso C, Spencer-Dene B, Zouboulis CC, Watt FM (2006). "HAN11 binds mDia1 and controls GLI1 transcriptional activity". J. Dermatol. Sci. 44 (1): 11–20. doi:10.1016/j.jdermsci.2006.06.001. PMID   16887337.
• Nissen RM, Amsterdam A, Hopkins N (2006). "A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression". BMC Dev. Biol. 6 (28): 28. doi: 10.1186/1471-213X-6-28 . PMC   1523201 . PMID   16759393.
• Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, Nissen RM (2010). "The zebrafish dyrk1b gene is important for endoderm formation". Genesis. 48 (1): 20–30. doi:10.1002/dvg.20578. PMC   2806492 . PMID   20014342.
• Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML (2010). "The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions". EMBO J. 29 (22): 3750–61. doi:10.1038/emboj.2010.251. PMC   2989105 . PMID   20940704.

External links

• DCAF7 human gene location in the UCSC Genome Browser .
• DCAF7 human gene details in the UCSC Genome Browser .