WDR8

WRAP73
Identifiers
Aliases	WRAP73 , WDR8, WD repeat containing, antisense to TP73
External IDs	OMIM: 606040; MGI: 1891749; HomoloGene: 9857; GeneCards: WRAP73; OMA:WRAP73 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.32 Start 3,630,767 bp [1] End 3,652,761 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 E2 Start 154,226,829 bp [2] End 154,251,877 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte gonad right hemisphere of cerebellum mucosa of transverse colon spleen anterior pituitary apex of heart blood monocyte body of stomach Top expressed in condyle fossa medial ganglionic eminence Rostral migratory stream motor neuron saccule facial motor nucleus internal carotid artery external carotid artery medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm centrosome centriole cytoskeleton ciliary basal body microtubule organizing center Biological process positive regulation of non-motile cilium assembly cell projection organization mitotic spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 49856 59002 Ensembl ENSG00000116213 ENSMUSG00000029029 UniProt Q9P2S5 Q9JM98 RefSeq (mRNA) NM_017818 NM_021499 RefSeq (protein) NP_060288 NP_067474 Location (UCSC) Chr 1: 3.63 – 3.65 Mb Chr 4: 154.23 – 154.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene. ^[5]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification (osteogenesis). ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000116213 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029029 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: WDR8 WD repeat domain 8".

Further reading

• Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID   11401440.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.