WDR8

WRAP73
Identifiers
Aliases	WRAP73 , WDR8, WD repeat containing, antisense to TP73
External IDs	OMIM: 606040 MGI: 1891749 HomoloGene: 9857 GeneCards: WRAP73
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.32 Start 3,630,767 bp [1] End 3,652,761 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 E2 Start 154,226,829 bp [2] End 154,251,877 bp [2]
RNA expression pattern Bgee Top expressed in blood body of stomach bone marrow cerebellar hemisphere fundus esophagus spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001948 protein binding Cellular component cytoplasm centrosome centriole cytoskeleton ciliary basal body microtubule organizing center Biological process positive regulation of non-motile cilium assembly cell projection organization mitotic spindle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	49856	59002
Ensembl	ENSG00000116213	ENSMUSG00000029029
UniProt	Q9P2S5	Q9JM98
RefSeq (mRNA)	NM_017818	NM_021499
RefSeq (protein)	NP_060288	NP_067474
Location (UCSC)	Chr 1: 3.63 – 3.65 Mb	Chr 4: 154.23 – 154.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene. ^[5]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification (osteogenesis). ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000116213 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029029 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: WDR8 WD repeat domain 8".

Further reading

• Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID   11401440.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.