WFDC5

WFDC5
Identifiers
Aliases	WFDC5 , PRG5, WAP1, dJ211D12.5, WAP four-disulfide core domain 5
External IDs	OMIM: 605161 MGI: 2384800 HomoloGene: 17072 GeneCards: WFDC5
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,115,172 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,024,662 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; nipple; ; human penis; ; vulva; ; sperm; ; cavity of mouth; ; thymus; ; vagina; ; palpebral conjunctiva; ; body of tongue;
	Top expressed in
	esophagus; ; lip; ; skin of back; ; skin of abdomen; ; cervix; ; belly cord; ; stomach; ; epidermis; ; limb; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity ; serine-type endopeptidase inhibitor activity ;
Cellular component	extracellular region ;
Biological process	negative regulation of endopeptidase activity ; negative regulation of peptidase activity ;
	Sources:Amigo / QuickGO
Orthologs
	149708
	209232
	ENSG00000175121
	ENSMUSG00000040154
	Q8TCV5
	n/a
	NM_145652 ; NM_001395506
	NM_145369
	NP_663627
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5 gene.^[5]^[6]^[7]

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.^[7]

Related Research Articles

In molecular biology, the Whey acidic proteins (WAP) have been identified as a major whey protein family in milk, and are important in regulating the proliferation of mammary epithelial cells. Additionally, their physiological function is thought to be similar to a protease inhibitor. It has been concluded, therefore, that WAP regulate the proliferation of mammary epithelial cells by preventing elastase-type serine proteases from carrying out laminin degradation and by suppressing the MAP kinase signal pathway in the cell cycle.

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.

Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.

Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DBT gene.

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial is an enzyme that in humans is encoded by the DLST gene.

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.

WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.

ATP-dependent DNA helicase Q1 is an enzyme that in humans is encoded by the RECQL gene.

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.

Pregnancy-specific beta-1-glycoprotein 5 is a protein that in humans is encoded by the PSG5 gene.

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.

Serpin B13 is a protein that in humans is encoded by the SERPINB13 gene.

Pregnancy-specific beta-1-glycoprotein 4 is a protein that in humans is encoded by the PSG4 gene.

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.

Eppin is a protein that in humans is encoded by the SPINLW1 gene.

WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.

Zinc finger and SCAN domain-containing protein 21 is a protein that in humans is encoded by the ZSCAN21 gene.

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene. when found in humans.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175121 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040154 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987 . PMID 12206714.
↑ Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (Mar 2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling". J Mol Graph Model. 17 (2): 106–13, 134–6. doi:10.1016/S1093-3263(99)00023-6. PMID 10680116.
1 2 "Entrez Gene: WFDC5 WAP four-disulfide core domain 5".

Horikoshi N, Cong J, Kley N, Shenk T (1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochem. Biophys. Res. Commun. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nukumi N, Seki M, Iwamori T, et al. (2006). "Analysis of the promoter of mutated human whey acidic protein (WAP) gene". J. Reprod. Dev. 52 (2): 315–20. doi: 10.1262/jrd.17068 . PMID 16462094.
Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMC 1942171 . PMID 17511965.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175121 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040154 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12206714-5] Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC 1222987 . PMID 12206714.

[pmid10680116-6] Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (Mar 2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling". J Mol Graph Model. 17 (2): 106–13, 134–6. doi:10.1016/S1093-3263(99)00023-6. PMID 10680116.

[entrez-7] 1 2 "Entrez Gene: WFDC5 WAP four-disulfide core domain 5".

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WFDC5

Related Research Articles

References

Further reading