WFDC5

WFDC5
Identifiers
Aliases	WFDC5 , PRG5, WAP1, dJ211D12.5, WAP four-disulfide core domain 5
External IDs	OMIM: 605161; MGI: 2384800; HomoloGene: 17072; GeneCards: WFDC5; OMA:WFDC5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 45,109,452 bp [1] End 45,115,172 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 164,018,247 bp [2] End 164,024,662 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of abdomen skin of leg skin of thigh nipple human penis skin of hip vulva testicle gingival epithelium Top expressed in esophagus lip skin of external ear skin of back skin of abdomen cervix umbilical cord gastrula stomach epidermis More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region Biological process negative regulation of endopeptidase activity negative regulation of peptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 149708 209232 Ensembl ENSG00000175121 ENSMUSG00000040154 UniProt Q8TCV5 n/a RefSeq (mRNA) NM_145652 NM_001395506 NM_145369 RefSeq (protein) NP_663627 n/a Location (UCSC) Chr 20: 45.11 – 45.12 Mb Chr 2: 164.02 – 164.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5 gene. ^{[5] [6] [7]}

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000175121 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040154 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMC   1222987 . PMID   12206714.
6. Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR (Mar 2000). "The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling". J Mol Graph Model. 17 (2): 106–13, 134–6. doi:10.1016/S1093-3263(99)00023-6. PMID   10680116.
7. "Entrez Gene: WFDC5 WAP four-disulfide core domain 5".

Further reading

• Horikoshi N, Cong J, Kley N, Shenk T (1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochem. Biophys. Res. Commun. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID   10441517.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nukumi N, Seki M, Iwamori T, et al. (2006). "Analysis of the promoter of mutated human whey acidic protein (WAP) gene". J. Reprod. Dev. 52 (2): 315–20. doi: 10.1262/jrd.17068 . PMID   16462094.
• Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMC   1942171 . PMID   17511965.