WIF1

Last updated
WIF1
Protein WIF1 PDB 2d3j.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases WIF1 , WIF-1, WNT inhibitory factor 1
External IDs OMIM: 605186 MGI: 1344332 HomoloGene: 31430 GeneCards: WIF1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007191

NM_011915

RefSeq (protein)

NP_009122

NP_036045

Location (UCSC) Chr 12: 65.05 – 65.12 Mb Chr 10: 120.87 – 120.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. [5] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling. [6] [7] [8]

Contents

Function

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals. [5]

Related Research Articles

<span class="mw-page-title-main">Proto-oncogene Wnt-1</span> Protein-coding gene in the species Homo sapiens

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 gene.

<span class="mw-page-title-main">Frizzled-7</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Secreted frizzled-related protein 1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LRP6</span> Protein-coding gene in the species Homo sapiens

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.

<span class="mw-page-title-main">WNT3A</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.

<span class="mw-page-title-main">HIC1</span> Protein-coding gene in the species Homo sapiens

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.

<span class="mw-page-title-main">HBP1</span> Protein-coding gene in the species Homo sapiens

HMG-box transcription factor 1, also known as HBP1, is a human protein.

<span class="mw-page-title-main">DKK3</span> Protein-coding gene in the species Homo sapiens

Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.

<span class="mw-page-title-main">AXIN2</span> Protein-coding gene in the species Homo sapiens

Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.

<span class="mw-page-title-main">SFRP2</span> Protein-coding gene in the species Homo sapiens

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

<span class="mw-page-title-main">SFRP4</span> Protein-coding gene in the species Homo sapiens

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Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

<span class="mw-page-title-main">WNT10B</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene.

<span class="mw-page-title-main">DKK2</span> Protein-coding gene in the species Homo sapiens

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.

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Protein Wnt-9a is a protein that in humans is encoded by the WNT9A gene.

<span class="mw-page-title-main">SFRP5</span> Protein-coding gene in the species Homo sapiens

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.

<span class="mw-page-title-main">WNT2</span> Protein-coding gene in the species Homo sapiens

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.

In molecular biology, the protein domain, WIF N-terminal refers to the N terminal domain of the protein, WIF. It stands for, Wnt-inhibitory factor, whereby wnt is a signalling molecule also known as wingless. Wnt is a molecule in the wnt signaling pathway. The WIF domain binds to the wnt ligand since it inhibits it.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000156076 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020218 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: WIF1 WNT inhibitory factor 1".
  6. Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC   3430870 . PMID   21743455.
  7. Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID   18256869. S2CID   31357937.
  8. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. 398 (6726): 431–6. Bibcode:1999Natur.398..431H. doi:10.1038/18899. PMID   10201374. S2CID   4376660.

Further reading