WIF1

Last updated
WIF1
Protein WIF1 PDB 2d3j.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases WIF1 , WIF-1, WNT inhibitory factor 1
External IDs OMIM: 605186; MGI: 1344332; HomoloGene: 31430; GeneCards: WIF1; OMA:WIF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007191

NM_011915

RefSeq (protein)

NP_009122

NP_036045

Location (UCSC) Chr 12: 65.05 – 65.12 Mb Chr 10: 120.87 – 120.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. [5] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling. [6] [7] [8]

Contents

Function

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000156076 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020218 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: WIF1 WNT inhibitory factor 1".
  6. Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC   3430870 . PMID   21743455.
  7. Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID   18256869. S2CID   31357937.
  8. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. 398 (6726): 431–6. Bibcode:1999Natur.398..431H. doi:10.1038/18899. PMID   10201374. S2CID   4376660.

Further reading