WRNIP1

WRNIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VHS, 3VHT
Identifiers
Aliases	WRNIP1 , WHIP, bA420G6.2, Werner helicase interacting protein 1, WRN helicase interacting protein 1, CFAP93, FAP93
External IDs	OMIM: 608196 MGI: 1926153 HomoloGene: 10592 GeneCards: WRNIP1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p25.2 Start 2,765,393 bp [1] End 2,786,952 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.2 Start 32,986,021 bp [2] End 33,006,592 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus cerebellar hemisphere anterior pituitary cerebellar vermis body of pancreas Brodmann area 9 prefrontal cortex body of tongue tibialis anterior muscle islet of Langerhans Top expressed in habenula ventromedial nucleus supraoptic nucleus Paneth cell dorsomedial hypothalamic nucleus endocardial cushion atrioventricular valve condyle paraventricular nucleus of hypothalamus suprachiasmatic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding ATPase activity protein binding hydrolase activity ATP binding metal ion binding identical protein binding enzyme activator activity single-stranded DNA helicase activity Cellular component perinuclear region of cytoplasm membrane nucleus cytoplasm replisome Biological process DNA replication DNA synthesis involved in DNA repair regulation of DNA-dependent DNA replication initiation DNA repair cellular response to DNA damage stimulus immune system process DNA-dependent DNA replication regulation of DNA repair DNA recombination DNA replication, Okazaki fragment processing positive regulation of catalytic activity innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56897 78903 Ensembl ENSG00000124535 ENSMUSG00000021400 UniProt Q96S55 Q91XU0 RefSeq (mRNA) NM_020135 NM_130395 NM_030215 RefSeq (protein) NP_064520 NP_569079 NP_084491 Location (UCSC) Chr 6: 2.77 – 2.79 Mb Chr 13: 32.99 – 33.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATPase WRNIP1 is an enzyme that is encoded by the WRNIP1 gene in humans. ^{[5] [6]} The protein is a member of AAA ATPase family.

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene. ^[6]

Interactions

WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000124535 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021400 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem. 276 (23): 20364–9. doi: 10.1074/jbc.C100035200 . PMID   11301316.
6. "Entrez Gene: WRNIP1 Werner helicase interacting protein 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID   15670210. S2CID   24977510.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Bish RA, Myers MP (2007). "Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain". J. Biol. Chem. 282 (32): 23184–93. doi: 10.1074/jbc.M701042200 . PMID   17550899.

External links

• FactorBook WHIP