WSB1

WSB1
Identifiers
Aliases	WSB1 , SWIP1, WSB-1, WD repeat and SOCS box containing 1
External IDs	OMIM: 610091 MGI: 1926139 HomoloGene: 9218 GeneCards: WSB1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.1 Start 27,294,076 bp [1] End 27,315,926 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 79,130,198 bp [2] End 79,145,497 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum gastric mucosa lower lobe of lung inferior ganglion of vagus nerve tibial nerve Region I of hippocampus proper canal of the cervix endothelial cell left uterine tube upper lobe of lung Top expressed in medullary collecting duct cumulus cell neural tube dorsomedial hypothalamic nucleus pineal gland vas deferens dermis paraventricular nucleus of hypothalamus ventral tegmental area atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component intracellular anatomical structure cytosol Biological process protein ubiquitination intracellular signal transduction protein polyubiquitination post-translational protein modification biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26118 78889 Ensembl ENSG00000109046 ENSMUSG00000017677 UniProt Q9Y6I7 O54927 RefSeq (mRNA) NM_015626 NM_134264 NM_134265 NM_001348350 NM_001042565 NM_019653 RefSeq (protein) NP_056441 NP_599027 NP_001335279 NP_001036030 NP_062627 Location (UCSC) Chr 17: 27.29 – 27.32 Mb Chr 11: 79.13 – 79.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene. ^{[5] [6] [7]}

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000109046 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017677 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vasiliauskas D, Hancock S, Stern CD (Aug 1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development". Mech Dev. 82 (1–2): 79–94. doi: 10.1016/S0925-4773(99)00014-3 . PMID   10354473. S2CID   15357835.
6. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID   12076535.
7. "Entrez Gene: WSB1 WD repeat and SOCS box-containing 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi: 10.1074/jbc.M103093200 . PMID   11384984.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Dentice M, Bandyopadhyay A, Gereben B, et al. (2005). "The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate". Nat. Cell Biol. 7 (7): 698–705. doi:10.1038/ncb1272. PMC   1761694 . PMID   15965468.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC   1422157 . PMID   16498413.
• Chen QR, Bilke S, Wei JS, et al. (2006). "Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma". Genes Chromosomes Cancer. 45 (9): 856–62. doi:10.1002/gcc.20349. PMID   16804916. S2CID   3099056.