Wd repeat containing planar cell polarity effector

WDPCP
Identifiers
Aliases	WDPCP , BBS15, C2orf86, FRITZ, FRTZ, CHDTHP, WD repeat containing planar cell polarity effector, CPLANE5
External IDs	OMIM: 613580 MGI: 2144467 HomoloGene: 9299 GeneCards: WDPCP
Gene location (Human)
Chr.	Chromosome 2 (human)
End	63,827,843 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	21,848,989 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; superficial temporal artery; ; sperm; ; pancreatic epithelial cell; ; germinal epithelium; ; cardia; ; bronchial epithelial cell; ; ventral tegmental area; ; corpus callosum; ; tibia;
	Top expressed in
	fourth ventricle; ; spermatocyte; ; spermatid; ; seminiferous tubule; ; nasolacrimal duct; ; respiratory epithelium; ; olfactory epithelium; ; proximal tubule; ; seminal vesicula; ; pharynx;
	More reference expression data
	n/a
Orthologs
	51057
	216560
	ENSG00000143951
	ENSMUSG00000020319
	O95876
	Q8C456
	NM_001042692 ; NM_015910 ; NM_001354044 ; NM_001354045
	NM_145425 ; NM_001364768
	NP_001036157 ; NP_056994 ; NP_001340973 ; NP_001340974
	NP_663400 ; NP_001351697
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

WD repeat containing planar cell polarity effector is a protein that in humans is encoded by the WDPCP gene. ^[5]

Function

This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants.

Related Research Articles

Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ARVCF gene.

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.

tRNA -methyltransferase subunit WDR4 is an enzyme that in humans is encoded by the WDR4 gene.

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.

Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.

Bromodomain and WD repeat-containing protein 3 is a protein that in humans is encoded by the BRWD3 gene.

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.

Guanine nucleotide-binding protein subunit beta-like protein 1 is a protein that in humans is encoded by the GNB1L gene.

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.

Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.

Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.

Protein Wnt-9b is a protein that in humans is encoded by the WNT9B gene.

Cell growth regulator with EF-hand domain 1 is a protein that in humans is encoded by the CGREF1 gene.

Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene.

Prickle planar cell polarity protein 2 is a protein that in humans is encoded by the PRICKLE2 gene.

WD repeat domain 76 is a protein that in humans is encoded by the WDR76 gene.

Phospholipase A2 group IVE is a protein that in humans is encoded by the PLA2G4E gene.

VANGL planar cell polarity protein 2 is a protein that in humans is encoded by the VANGL2 gene.

Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene.

Disco interacting protein 2 homolog C is a protein that in humans is encoded by the DIP2C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143951 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020319 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: WD repeat containing planar cell polarity effector" . Retrieved 2017-06-07.

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143951 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020319 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WD repeat containing planar cell polarity effector" . Retrieved 2017-06-07.

[1]

[2]

[3]

[4]

[5]

Wd repeat containing planar cell polarity effector

Contents

Function

Related Research Articles

References

Further reading