Interstate 65 (I-65) is a major north–south Interstate Highway in the central United States. As with most primary Interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12), and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.
U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as Pacific Avenue, in the city's Oceanfront resort district at the intersection of 5th Street and Winston-Salem Avenue. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.
William Huston Natcher was a Democratic congressman, serving in the United States House of Representatives from 1953 until his death from heart failure in Bethesda, Maryland in 1994. He is the second longest-serving member ever of the United States House of Representatives from the Commonwealth of Kentucky.
U.S. Route 231 (US 231) is a north-south U.S highway that is a parallel route of US 31. It runs for 912 miles (1,468 km) from St. John, Indiana, at US 41 to south of US 98 in downtown Panama City, Florida. One of its most notable landmarks is the William H. Natcher Bridge, a 0.853 miles (1.373 km) long cable-stayed bridge that connects Rockport, Indiana, to Owensboro, Kentucky, spanning the Ohio River.
Interstate 265 (I-265) is a 41.8-mile (67.3 km) Interstate Highway partially encircling the Louisville metropolitan area. Starting from I-65 in the southern part of Louisville, it runs through Jefferson County, Kentucky, crosses the Ohio River on the Lewis and Clark Bridge into Indiana, meets I-65 for a second time, and then proceeds westbound to terminate at the I-64 interchange.
The William H. Natcher Green River Parkway was the designation for a 72.3-mile-long (116.4 km) freeway that ran from Bowling Green to Owensboro in the US commonwealth of Kentucky. The Natcher Parkway was one of nine highways that were a part of Kentucky's parkway system. The portion north of Interstate 65 (I-65) was signed as I-165, and the portion south of I-65 as Kentucky Route 9007 on March 6, 2019.
State Road 75, the highest two-digit route in the U.S. state of Indiana consists of two discontinuous north–south segments.
U.S. Route 31W is the westernmost of two parallel routes for U.S. Route 31 from Nashville, Tennessee to Louisville, Kentucky.
State Road 45 is a state route from Bean Blossom, Indiana to Scotland, Indiana in the southern half of the state.
U.S. Route 60 (US 60) is a major U.S. Highway in the American state of Kentucky. In the early days of the U.S. Highway System, US 60 was originally to be numbered as US 62. Following extensive lobbying and complaints filed by Kentucky governor William J. Fields to the American Association of State Highway Officials, the route was re-designated as US 60 before the system was finalized. In Kentucky, US 60 parallels the Ohio River. US 60 enters Kentucky from Cairo, Illinois, traveling northeast to Louisville, then takes a direct eastward route to rejoin the Ohio River in downtown Ashland, Kentucky. Both US 60 and US 23 run concurrently from Ashland to Catlettsburg where US 60 turns east and enters Kenova, West Virginia. US 60 is the longest route in Kentucky, running 495 miles (797 km) across the width of the state, passing through 22 of Kentucky's counties and through the cities of Paducah, Henderson, Owensboro, Louisville, the state capital of Frankfort, and Lexington.
Interstate 66 (I-66) is a canceled Interstate Highway designated in the Intermodal Surface Transportation Efficiency Act (ISTEA) of 1991 as the East–West TransAmerica Corridor and High Priority Corridor 3. The US Department of Transportation originally planned to extend the current I-66 from its western terminus at Middletown, Virginia, across the country to California. The route west of Kansas was not favored by any of the related state highway departments, and, as a result, I-66 west of Wichita, Kansas, through New Mexico, Arizona, Nevada and California was canceled. Among the reasons for this were lack of interest from any of the state highway departments, and the insufficient projected traffic did not justify an Interstate, especially since many segments had no preexisting highway. The National Park Service was strongly opposed to building I-66 across the Death Valley National Park. The choice for the number I-66 was a hope to capitalize on name association with the decommissioned US Route 66 (US 66). The case for westward expansion of I-66 was started by businesspeople in Wichita. Furthermore, there were no plans to build I-66 across the West Virginia–Virginia state line, leaving it as a non-contiguous highway. The I-66 concept was supported in Kentucky mainly because of the efforts of Representative Hal Rogers; however, the Kentucky Transportation Cabinet (KYTC) completed its feasibility study in 2005 and concluded that building I-66 was too costly and of little traffic benefit with high potential environmental impact and canceled the project in that state. The only remaining study of I-66 was conducted by the Federal Highway Administration (FHWA) and the Illinois Department of Transportation (IDOT) under the 66 Corridor Study, a Tier 1 environmental impact statement (EIS). This study was canceled August 6, 2015, by IDOT, and, subsequently, the FHWA announced the cancellation of the EIS in the Federal Register, ending the last I-66 project and therefore officially canceling the I-66 Trans America Highway.
U.S. Route 41 (US 41) in the state of Indiana is a north–south US Highway that is parallel to the Illinois state line. It enters the state south of Evansville as a four-lane divided highway passing around Vincennes and traveling north to Terre Haute. In Terre Haute, it is known as 3rd Street. North of Terre Haute, it hooks east and becomes a two-lane surface road. Those wanting to stay on a four-lane divided highway can use State Road 63 to the west. It passes through Rockville, Veedersburg, and Attica before returning to a four-lane divided highway when SR 63 terminates in Warren County. It remains a four-lane divided highway until Lake County, where it becomes a main road known as Indianapolis Boulevard. It overlaps US 12 and US 20 in Hammond and exits Indiana into the South Side of Chicago.
Interstate 65 (I-65) enters the US state of Kentucky from Tennessee, five miles (8.0 km) south of Franklin. It passes by the major cities of Bowling Green, Elizabethtown, and Louisville before exiting the state into Indiana.
U.S. Route 231 is the longest numbered highway in Indiana, covering over 284 miles (457 km). It is a main north–south highway in the western part of the state. The southern terminus of US 231 is at the Kentucky state line and the northern terminus is at US 41 just south of St. John. The highway is a mixture of expressway and two-lane roadway. The expressway portions exist mainly in southern Indiana and around the Lafayette area, with the rest mainly being two lanes.
U.S. Route 231 in Kentucky runs 86.465 miles (139.152 km) from the Tennessee state line near Adolphus to the William H. Natcher Bridge on the Ohio River near Rockport, Indiana. It crosses the state mainly in the west-central region, traversing Allen, Warren, Butler, Ohio, and Daviess Counties.
Kentucky Route 9007 is a 2.1-mile-long (3.4 km) four-lane limited-access highway, and was the unsigned designation for the entirety of the former William H. Natcher Parkway. KY 9007 is now the designation of the southernmost section of the former parkway between Interstate 65 (I-65) and U.S. Route 231, which opened in November 2011. KY 9007 was signed on March 6, 2019, when the majority of the Natcher Parkway was redesignated as I-165. KY 9007 functions as a connector, providing a bypass for traffic to utilize to avoid driving into Bowling Green itself by directly connecting I-165 to US 231. It was constructed for this purpose in order to provide some relief to US 231 through Bowling Green.
The Wendell H. Ford Expressway, also known as the Owensboro Bypass, is a major partial beltway that runs around the outer parts of the city of Owensboro, Kentucky. With a length of 13.057 miles (21.013 km), the expressway includes parts of U.S. Route 60 (US 60) and US 231.
Kentucky Route 2155 is an urban secondary north–south state highway located entirely in Owensboro in northwest Kentucky.
Kentucky Route 2262 is a 1.494-mile (2.404 km) state highway in Kentucky and a small portion of Indiana. It runs from Kentucky Route 54 and J.R. Miller Boulevard in downtown Owensboro, Kentucky, to Indiana State Road 161 on the north end of the Glover Cary Bridge, 0.245 miles (0.394 km) north of the Indiana state line.
Interstate 165 (I-165) is a 70.2-mile-long (113.0 km) auxiliary Interstate Highway in the US state of Kentucky. A spur route of I-65, it extends from I-65 in Bowling Green to U.S. Route 60 (US 60) and US 231 in Owensboro. It opened in 1972 as the Green River Parkway and was renamed the William H. Natcher Parkway in 1994. It was designated as I-165 in 2019 after completion of a project that brought the highway up to Interstate Highway standards.
US 231 
SR 66 
