XIRP2

XIRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F14
Identifiers
Aliases	XIRP2 , CMYA3, xin actin binding repeat containing 2
External IDs	OMIM: 609778; MGI: 2685198; HomoloGene: 19388; GeneCards: XIRP2; OMA:XIRP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q24.3 Start 166,888,480 bp [1] End 167,259,753 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C1.3 Start 67,004,178 bp [2] End 67,356,959 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in deltoid muscle biceps brachii Skeletal muscle tissue of rectus abdominis quadriceps femoris muscle vastus lateralis muscle tibialis anterior muscle Skeletal muscle tissue of biceps brachii myocardium of left ventricle body of tongue muscle of thigh Top expressed in muscle of thigh skeletal muscle tissue ventricle of the heart quadriceps femoris muscle interventricular septum left ventricle zone of skin esophagus lip superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function alpha-actinin binding actin binding actin filament binding Cellular component cell junction Z discdkac stress fiber focal adhesion filamentous actin Biological process heart development cell-cell junction organization cardiac muscle tissue morphogenesis ventricular septum development actin cytoskeleton organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 129446 241431 Ensembl ENSG00000163092 ENSMUSG00000027022 UniProt A4UGR9 Q4U4S6 RefSeq (mRNA) NM_152381 NM_001079810 NM_001199143 NM_001199144 NM_001199145 NM_001024618 NM_001083919 RefSeq (protein) NP_001073278 NP_001186072 NP_001186073 NP_001186074 NP_689594 NP_001019789 NP_001077388 Location (UCSC) Chr 2: 166.89 – 167.26 Mb Chr 2: 67 – 67.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Xin actin-binding repeat-containing protein 2 is a protein that in humans is encoded by the XIRP2 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000163092 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027022 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem. 281 (51): 39370–9. doi: 10.1074/jbc.M603244200 . PMID   17046827.
6. Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn. 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID   12203715. S2CID   23393425.
7. Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci. 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID   15454575. S2CID   5643531.
8. "Entrez Gene: CMYA3 cardiomyopathy associated 3".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Blasi F, Bacchelli E, Carone S, et al. (2006). "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample". Eur. J. Hum. Genet. 14 (1): 123–6. doi: 10.1038/sj.ejhg.5201444 . PMID   16205742.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Pan PW, Li K, Tuggle CK, et al. (2004). "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3)". Anim. Genet. 34 (6): 473–4. doi:10.1046/j.0268-9146.2003.01059.x. PMID   14687087.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.