XPO4

XPO4
Identifiers
Aliases	XPO4 , exp4, exportin 4
External IDs	OMIM: 611449 MGI: 1888526 HomoloGene: 10733 GeneCards: XPO4
Gene location (Human)
Chr.	Chromosome 13 (human)
End	20,903,048 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	57,665,430 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; secondary oocyte; ; deltoid muscle; ; tendon; ; gastrocnemius muscle; ; Achilles tendon; ; tibialis anterior muscle; ; thoracic diaphragm; ; islet of Langerhans; ; sural nerve;
	Top expressed in
	primitive streak; ; maxillary prominence; ; secondary oocyte; ; hair follicle; ; hand; ; spermatocyte; ; spermatid; ; foot; ; ureter; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nuclear export signal receptor activity ; protein binding ;
Cellular component	nuclear pore ; nucleus ; nucleoplasm ; cytoplasm ; cytosol ;
Biological process	positive regulation of protein export from nucleus ; protein transport ; nuclear export ; protein export from nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	64328
	57258
	ENSG00000132953
	ENSMUSG00000021952
	Q9C0E2
	Q9ESJ0
	NM_022459 ; NM_001372061
	NM_020506
	NP_071904 ; NP_001358990
	NP_065252 ; NP_001355626 ; NP_001355627
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 05, 2022

Exportin-4 is a protein that in humans is encoded by the XPO4 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132953 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021952 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID 11214970.
↑ Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Gorlich D (Sep 2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–71. doi:10.1093/emboj/19.16.4362. PMC 302028 . PMID 10944119.
↑ "Entrez Gene: XPO4 exportin 4".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288 . PMID 15057823.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Kurisaki A, Kurisaki K, Kowanetz M, et al. (2006). "The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran". Mol. Cell. Biol. 26 (4): 1318–32. doi:10.1128/MCB.26.4.1318-1332.2006. PMC 1367208 . PMID 16449645.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132953 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021952 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11214970-5] Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID 11214970.

[pmid10944119-6] Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Gorlich D (Sep 2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–71. doi:10.1093/emboj/19.16.4362. PMC 302028 . PMID 10944119.

[entrez-7] "Entrez Gene: XPO4 exportin 4".

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XPO4

Contents

See also

Related Research Articles

References

Further reading