XPO4

XPO4
Identifiers
Aliases	XPO4 , exp4, exportin 4
External IDs	OMIM: 611449; MGI: 1888526; HomoloGene: 10733; GeneCards: XPO4; OMA:XPO4 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q12.11 Start 20,777,329 bp [1] End 20,903,048 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C3 Start 57,577,521 bp [2] End 57,665,430 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii secondary oocyte muscle of thigh deltoid muscle testicle tendon gastrocnemius muscle Achilles tendon Top expressed in primitive streak epiblast maxillary prominence mandibular prominence zygote tail of embryo Rostral migratory stream secondary oocyte hair follicle hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclear export signal receptor activity protein binding Cellular component nuclear pore nucleus nucleoplasm cytoplasm cytosol Biological process positive regulation of protein export from nucleus protein transport nuclear export protein export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64328 57258 Ensembl ENSG00000132953 ENSMUSG00000021952 UniProt Q9C0E2 Q9ESJ0 RefSeq (mRNA) NM_022459 NM_001372061 NM_020506 RefSeq (protein) NP_071904 NP_001358990 NP_065252 NP_001355626 NP_001355627 Location (UCSC) Chr 13: 20.78 – 20.9 Mb Chr 14: 57.58 – 57.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Exportin-4 is a protein that in humans is encoded by the XPO4 gene. ^{[5] [6] [7]}

See also

• Chromosome 13 (human)
• Protein transport
• Ran (gene)
• SMAD3

References

1. GRCh38: Ensembl release 89: ENSG00000132953 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021952 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
6. Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Gorlich D (Sep 2000). "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes". EMBO J. 19 (16): 4362–71. doi:10.1093/emboj/19.16.4362. PMC   302028 . PMID   10944119.
7. "Entrez Gene: XPO4 exportin 4".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Kurisaki A, Kurisaki K, Kowanetz M, et al. (2006). "The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran". Mol. Cell. Biol. 26 (4): 1318–32. doi:10.1128/MCB.26.4.1318-1332.2006. PMC   1367208 . PMID   16449645.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.