XPOT

XPOT
Identifiers
Aliases	XPOT , XPO3, exportin for tRNA
External IDs	OMIM: 603180 MGI: 1920442 HomoloGene: 38291 GeneCards: XPOT
Gene location (Human)
Chr.	Chromosome 12 (human)
End	64,451,125 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	121,462,237 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; endothelial cell; ; Brodmann area 23; ; islet of Langerhans; ; Achilles tendon; ; bone marrow cells; ; body of pancreas; ; middle temporal gyrus; ; ganglionic eminence; ; smooth muscle tissue;
	Top expressed in
	ureter; ; lacrimal gland; ; calvaria; ; renal corpuscle; ; fossa; ; condyle; ; parotid gland; ; hair follicle; ; substantia nigra; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tRNA binding ; RNA binding ;
Cellular component	cytoplasm ; nuclear matrix ; nuclear pore ; nucleus ; nucleoplasm ; cytosol ;
Biological process	intracellular protein transport ; tRNA re-export from nucleus ; tRNA export from nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	11260
	73192
	ENSG00000184575
	ENSMUSG00000034667
	O43592
	Q9CRT8
	NM_007235
	NM_001081056 ; NM_001359618 ; NM_001401044 ; NM_001401045
	NP_009166
	NP_001074525 ; NP_001346547 ; NP_001387973 ; NP_001387974
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 18, 2023

Exportin-T is a protein that in humans is encoded by the XPOT gene.^[5]^[6]^[7]

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.^[7]

Related Research Articles

A nuclear pore is a channel as part of the nuclear pore complex (NPC), a large protein complex found in the nuclear envelope in eukaryotic cells, enveloping the cell nucleus containing DNA, which facilitates the selective membrane transport of various molecules across the membrane.

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

Nuclear transport refers to the mechanisms by which molecules move across the nuclear membrane of a cell. The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complexes (NPCs). Although small molecules can enter the nucleus without regulation, macromolecules such as RNA and proteins require association with transport factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit.

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

Transportin-1 is a protein that in humans is encoded by the TNPO1 gene.

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.

ATP-dependent RNA helicase DDX3X is an enzyme that in humans is encoded by the DDX3X gene.

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

gene ID :57510

Importin-7 is a protein that in humans is encoded by the IPO7 gene.

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.

Exportin-6 is a protein that in humans is encoded by the XPO6 gene.

Exportin-4 is a protein that in humans is encoded by the XPO4 gene.

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

Importin-13 is a protein encoded by the IPO13 gene in humans. Importin-13 is a member of the importin-β family of nuclear transport receptors (NTRs) and was first identified as a transport receptor in 2000. According to PSI-blast based secondary structure PREDiction (PSIPRED), importin-13 contains 38 α-helices. Importin-13 accommodates a range of cargoes due to its flexible superhelical structure and a cargo binding and release system that is distinct from other importin-like transport receptors. IPO13 is broadly expressed in a variety of tissues in the human body, including the heart, cornea, fetal lung, brain, endometrial carcinoma, and testes.

Rev is a transactivating protein that is essential to the regulation of HIV-1 protein expression. A nuclear localization signal is encoded in the rev gene, which allows the Rev protein to be localized to the nucleus, where it is involved in the export of unspliced and incompletely spliced mRNAs. In the absence of Rev, mRNAs of the HIV-1 late (structural) genes are retained in the nucleus, preventing their translation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184575 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034667 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi: 10.1016/S1097-2765(00)80036-2 . PMID 9660920.
↑ Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi: 10.1016/S0960-9822(98)70130-7 . PMID 9512417. S2CID 17803674.
1 2 "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)".

Arts GJ, Kuersten S, Romby P, et al. (1999). "The role of exportin-t in selective nuclear export of mature tRNAs". EMBO J. 17 (24): 7430–41. doi:10.1093/emboj/17.24.7430. PMC 1171087 . PMID 9857198.
Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex". Biochem. J. 346 (1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829 . PMID 10657246.
Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily". J. Biol. Chem. 275 (51): 40163–8. doi: 10.1074/jbc.M006242200 . hdl: 11858/00-001M-0000-0015-3D4E-B . PMID 11024021.
Kuersten S, Arts GJ, Walther TC, et al. (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains". Mol. Cell. Biol. 22 (16): 5708–20. doi:10.1128/MCB.22.16.5708-5720.2002. PMC 133969 . PMID 12138183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells". Biomed. Res. 27 (2): 89–92. doi: 10.2220/biomedres.27.89 . PMID 16707848.
Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA". RNA Biol. 3 (4): 145–9. doi: 10.4161/rna.3.4.3679 . PMID 17224653.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000184575 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034667 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9660920-5] Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi: 10.1016/S1097-2765(00)80036-2 . PMID 9660920.

[pmid9512417-6] Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi: 10.1016/S0960-9822(98)70130-7 . PMID 9512417. S2CID 17803674.

[entrez-7] 1 2 "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)".

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XPOT

Related Research Articles

References

Further reading