XPOT

Last updated
XPOT
Identifiers
Aliases XPOT , XPO3, exportin for tRNA
External IDs OMIM: 603180; MGI: 1920442; HomoloGene: 38291; GeneCards: XPOT; OMA:XPOT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007235

NM_001081056
NM_001359618
NM_001401044
NM_001401045

RefSeq (protein)

NP_009166

NP_001074525
NP_001346547
NP_001387973
NP_001387974

Location (UCSC) Chr 12: 64.4 – 64.45 Mb Chr 10: 121.42 – 121.46 Mb
PubMed search [3] [4]
Wikidata
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Exportin-T is a protein that in humans is encoded by the XPOT gene. [5] [6] [7]

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184575 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034667 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi: 10.1016/S1097-2765(00)80036-2 . PMID   9660920.
  6. Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi: 10.1016/S0960-9822(98)70130-7 . PMID   9512417. S2CID   17803674.
  7. 1 2 "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)".

Further reading