YTHDC2

YTHDC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YU6
Identifiers
Aliases	YTHDC2 , CAHL, YTH domain containing 2, hYTHDC2
External IDs	OMIM: 616530 MGI: 2448561 HomoloGene: 11265 GeneCards: YTHDC2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,595,285 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	45,022,791 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; hair follicle; ; tibia; ; Achilles tendon; ; Brodmann area 23; ; germinal epithelium; ; visceral pleura; ; palpebral conjunctiva; ; superficial temporal artery; ; parietal pleura;
	Top expressed in
	secondary oocyte; ; spermatocyte; ; cumulus cell; ; pineal gland; ; semi-lunar valve; ; aortic valve; ; primitive streak; ; supraoptic nucleus; ; Paneth cell; ; atrium;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; protein binding ; RNA polymerase binding ; ATP binding ; hydrolase activity ; helicase activity ; nucleic acid binding ; ATP-dependent activity, acting on RNA ; RNA binding ; N6-methyladenosine-containing RNA binding ; 3'-5' RNA helicase activity ;
Cellular component	endoplasmic reticulum ; cytoplasm ; nucleus ; ribonucleoprotein granule ;
Biological process	response to tumor necrosis factor ; RNA processing ; response to interleukin-1 ; positive regulation by host of viral genome replication ; spermatogenesis ; spermatid development ; cell differentiation ; oogenesis ; oocyte development ; meiosis ; germline cell cycle switching, mitotic to meiotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	64848
	240255
	ENSG00000047188
	ENSMUSG00000034653
	Q9H6S0
	B2RR83
	NM_022828 ; NM_001345975 ; NM_001345976
	NM_001163013
	NP_001332904 ; NP_001332905 ; NP_073739
	NP_001156485
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 31, 2024

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000047188 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034653 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: YTH domain containing 2".

Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR (April 2011). "Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients". Journal of Human Genetics. 56 (4): 316–23. doi:10.1038/jhg.2011.12. PMC 5825003 . PMID 21326311.
Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F (April 2011). Klein R (ed.). "Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B". PLOS ONE. 6 (4): e18285. Bibcode:2011PLoSO...618285M. doi: 10.1371/journal.pone.0018285 . PMC 3084704 . PMID 21559518.
Gano JJ, Simon JA (February 2010). "A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics. 9 (2): 255–70. doi: 10.1074/mcp.M900261-MCP200 . PMC 2830838 . PMID 19875381.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000047188 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034653 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: YTH domain containing 2".

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YTHDC2

Related Research Articles

References

Further reading