Yi Tang (biochemist)

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Yi Tang is a biochemist and professor in the Department of Chemistry and Biochemistry and the Department of Chemical and Biomolecular Engineering at the University of California, Los Angeles. [1] [2] His research interests include the discovery, functional characterization, and engineering of natural product biosynthetic enzymes. [3] He was awarded the 2014 Eli Lilly Award in Biological Chemistry. [4]

Contents

Education

Tang attended college at Pennsylvania State University and earned his PhD in Chemistry in 2002 from the California Institute of Technology, where he worked in the lab of Professor David Tirrell. [5]

Career and research

From 2002 to 2004, Tang pursued postdoctoral studies at the Stanford University in the lab of Professor Chaitan Khosla. In 2004, Tang joined the faculty of the Department of Chemical and Biomolecular Engineering the University of California, Los Angeles. His group's research has focused on studying the biosynthesis of natural products from Streptomyces and filamentous fungi as well as engineering enzymes that can be used for the production of pharmaceutical compounds. One demonstration of the latter approach has been his group's development of a biocatalytic approach for making the commonly prescribed lipid-lowering medication simvastatin. [6] [7]

Web of Science lists 254 publications authored by Tang in peer-reviewed scientific journals that have been cited over 10,000 times, leading to an h-index of 58. [8] His lab's three most cited papers have been cited >180 times each. [9] [10] [11]

Awards and honors

[1] [2]

Related Research Articles

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References

  1. 1 2 "Yi Tang Lab@UCLA - Members". sites.google.com. Retrieved 2023-01-07.
  2. 1 2 "Tang, Yi". The David and Lucile Packard Foundation. Retrieved 2023-01-07.
  3. ↑ "Yi Tang". scholar.google.com. Retrieved 2023-01-07.
  4. ↑ ACS Division of Biological Chemistry (7 January 2023). "Previous Eli Lilly Award in Biological Chemistry Recipients" (PDF).
  5. ↑ Tang Y, Ghirlanda G, Petka WA, Nakajima T, DeGrado WF, Tirrell DA (April 2001). "Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability". Angewandte Chemie. 40 (8): 1494–1496. doi:10.1002/1521-3773(20010417)40:8<1494::AID-ANIE1494>3.0.CO;2-X. PMID   29712367.
  6. ↑ "Structural secrets of enzyme used to make popular anti-cholesterol drug revealed". ScienceDaily. Retrieved 2023-01-07.
  7. ↑ US EPA, OCSPP (2013-02-26). "Presidential Green Chemistry Challenge: 2012 Greener Synthetic Pathways Award". www.epa.gov. Retrieved 2023-01-07.
  8. ↑ "Web of Science". www.webofscience.com. Retrieved 2023-01-07.
  9. ↑ Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, et al. (September 2015). "Minimum Information about a Biosynthetic Gene cluster". Nature Chemical Biology. 11 (9): 625–631. doi:10.1038/nchembio.1890. PMC   5714517 . PMID   26284661.
  10. ↑ Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, et al. (April 2010). "Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis". Journal of the American Chemical Society. 132 (13): 4530–4531. doi:10.1021/ja100060k. PMC   2861853 . PMID   20222707.
  11. ↑ Ma SM, Li JW, Choi JW, Zhou H, Lee KK, Moorthie VA, et al. (October 2009). "Complete reconstitution of a highly reducing iterative polyketide synthase". Science. 326 (5952): 589–592. doi:10.1126/science.1175602. PMC   2875069 . PMID   19900898.
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