Yoda1

Last updated
Yoda1
Yoda1 structure.png
Names
Preferred IUPAC name
2-(5-{[(2,6-Dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
EC Number
  • 998-870-8
PubChem CID
UNII
  • InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
    Key: BQNXBSYSQXSXPT-UHFFFAOYSA-N
  • ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1
Properties
C13H8Cl2N4S2
Molar mass 355.27 g/mol
Hazards
GHS labelling:
GHS-pictogram-exclam.svg
Warning
H302
P264, P270, P301+P317, P330, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas. [1] [2] [3] [4] [5]

See also

References

  1. ↑ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E.; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C.; Engels, Ingo H.; Petrassi, H. Michael; Schumacher, Andrew M.; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (2015). "Chemical activation of the mechanotransduction channel Piezo1". eLife. 4 e07369. doi: 10.7554/eLife.07369 . PMC   4456433 . PMID   26001275. S2CID   2652667 .
  2. ↑ Cahalan, Stuart M.; Lukacs, Viktor; Ranade, Sanjeev S.; Chien, Shu; Bandell, Michael; Patapoutian, Ardem (2015). "Piezo1 links mechanical forces to red blood cell volume". eLife. 4 e07370. doi: 10.7554/eLife.07370 . PMC   4456639 . PMID   26001274. S2CID   15018525 .
  3. ↑ Wang, ShengPeng; Chennupati, Ramesh; Kaur, Harmandeep; Iring, Andras; Wettschureck, Nina; Offermanns, Stefan (2016). "Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release". Journal of Clinical Investigation. 126 (12): 4527–4536. doi: 10.1172/JCI87343 . PMC   5127677 . PMID   27797339. S2CID   38263363 .
  4. ↑ Rapetti-Mauss, Raphaël; Picard, Véronique; Guitton, Corinne; Ghazal, Khaldoun; Proulle, Valérie; Badens, Catherine; Soriani, Olivier; Garçon, Loïc; Guizouarn, Hélène (2017). "Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis". Haematologica. 102 (10): e415 –e418. doi: 10.3324/haematol.2017.171389 . PMC   5622875 . PMID   28619848. S2CID   31756119 .
  5. ↑ Gnanasambandam, R.; Gottlieb, P. A.; Sachs, F. (2017). "The Kinetics and the Permeation Properties of Piezo Channels". In Gottlieb, Philip A. (ed.). Piezo Channels. Current Topics in Membranes. Vol. 79. Academic Press. pp. 275–307. doi:10.1016/bs.ctm.2016.11.004. ISBN   978-0-12-809389-4. PMID   28728821. S2CID   3743286.


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