ZBED3

ZBED3
Identifiers
Aliases	ZBED3 , zinc finger BED-type containing 3
External IDs	OMIM: 615250; MGI: 1919364; HomoloGene: 12442; GeneCards: ZBED3; OMA:ZBED3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q13.3 Start 77,072,072 bp [1] End 77,087,285 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D1 Start 95,460,120 bp [2] End 95,474,349 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte mucosa of ileum retinal pigment epithelium smooth muscle tissue left lobe of thyroid gland subcutaneous adipose tissue right lobe of thyroid gland parotid gland body of uterus body of pancreas Top expressed in secondary oocyte zygote primary oocyte genital tubercle tail of embryo ventricular zone yolk sac right kidney choroid plexus of fourth ventricle lactiferous gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm membrane cytosol Biological process positive regulation of canonical Wnt signaling pathway negative regulation of protein phosphorylation protein stabilization Wnt signaling pathway positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84327 72114 Ensembl ENSG00000132846 ENSMUSG00000041995 UniProt Q96IU2 Q9D0L1 RefSeq (mRNA) NM_032367 NM_001329564 NM_028106 NM_001302538 NM_001302539 RefSeq (protein) NP_001316493 NP_115743 NP_001289467 NP_001289468 NP_082382 Location (UCSC) Chr 5: 77.07 – 77.09 Mb Chr 13: 95.46 – 95.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger BED domain-containing protein 3 also known as axin-interacting protein is a protein in humans that is encoded by the ZBED3 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000132846 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041995 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger, BED-type containing 3".

Further reading

• Hayward A, Ghazal A, Andersson G, Andersson L, Jern P (2013). Robinson-Rechavi M (ed.). "ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions". PLOS ONE. 8 (3) e59940. Bibcode:2013PLoSO...859940H. doi: 10.1371/journal.pone.0059940 . PMC   3606216 . PMID   23533661.
• de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, Meigs JB (Jan 2011). "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms" (PDF). Diabetes Care. 34 (1): 121–5. doi:10.2337/dc10-1265. PMC   3005447 . PMID   20889853.
• Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L (Mar 2009). "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling". The Journal of Biological Chemistry. 284 (11): 6683–9. doi: 10.1074/jbc.M807753200 . PMC   2652294 . PMID   19141611.
• Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, et al. (Jul 2010). "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nature Genetics. 42 (7): 579–89. doi:10.1038/ng.609. PMC   3080658 . PMID   20581827.