ZBED6

ZBED6
Identifiers
Aliases	ZBED6 , MGR, zinc finger BED-type containing 6
External IDs	OMIM: 613512; MGI: 3828086; HomoloGene: 130066; GeneCards: ZBED6; OMA:ZBED6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 203,795,714 bp [1] End 203,854,999 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 133,547,678 bp [2] End 133,589,056 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell gonad epithelium of colon tonsil islet of Langerhans stromal cell of endometrium Achilles tendon duodenum smooth muscle tissue sural nerve Top expressed in ascending aorta aortic valve tail of embryo olfactory tubercle genital tubercle arcuate nucleus median eminence medial geniculate nucleus inferior colliculi paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity metal ion binding DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleolus nucleus Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100381270 667118 Ensembl ENSG00000257315 ENSMUSG00000094410 UniProt P86452 D2EAC2 RefSeq (mRNA) NM_001174108 NM_001395895 NM_001166552 NM_001395904 RefSeq (protein) NP_001167579 NP_001160024 NP_001382833 Location (UCSC) Chr 1: 203.8 – 203.85 Mb Chr 1: 133.55 – 133.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger, BED-type containing 6 is a protein that in humans is encoded by the ZBED6 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000257315 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000094410 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger, BED-type containing 6" . Retrieved 2012-03-15.

Further reading

• Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjälm G, Andersson L (Dec 2009). O'Rahilly S (ed.). "ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth". PLOS Biology. 7 (12) e1000256. doi: 10.1371/journal.pbio.1000256 . PMC   2780926 . PMID   20016685.
• Butter F, Kappei D, Buchholz F, Vermeulen M, Mann M (Apr 2010). "A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth". EMBO Reports. 11 (4): 305–11. doi:10.1038/embor.2010.6. PMC   2854606 . PMID   20134481.
• Andersson L (2010). "Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin". Cold Spring Harbor Symposia on Quantitative Biology. 74: 319–25. doi: 10.1101/sqb.2009.74.039 . PMID   20375320.