ZC3H11A

ZC3H11A
Identifiers
Aliases	ZC3H11A , ZC3HDC11A, zinc finger CCCH-type containing 11A
External IDs	OMIM: 613513; MGI: 1917829; HomoloGene: 8888; GeneCards: ZC3H11A; OMA:ZC3H11A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 203,795,654 bp [1] End 203,854,999 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endometrium lymph node cerebellar hemisphere Achilles tendon right hemisphere of cerebellum ventricular zone skin of abdomen pituitary gland skin of leg n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific mRNA binding Cellular component transcription export complex nucleoplasm Biological process poly(A)+ mRNA export from nucleus mRNA transport RNA export from nucleus termination of RNA polymerase II transcription mRNA 3'-end processing mRNA export from nucleus transport regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9877 70579 Ensembl ENSG00000058673 ENSMUSG00000102976 ENSMUSG00000116275 UniProt O75152 Q6NZF1 RefSeq (mRNA) NM_014827 NM_001319238 NM_001319239 NM_001350261 NM_001350262 NM_001350263 NM_001350264 NM_001350265 NM_001350266 NM_001276767 NM_144530 NM_001357228 RefSeq (protein) NP_001306167 NP_001306168 NP_055642 NP_001337190 NP_001337191 NP_001337192 NP_001337193 NP_001337194 NP_001337195 NP_001363263 NP_001363264 NP_001363265 NP_001363266 NP_001363267 NP_001363268 NP_001363269 NP_001363270 NP_001363271 NP_001363272 NP_001363273 NP_001363274 NP_001363275 NP_001363276 NP_001363277 NP_001363278 NP_001363279 NP_001363280 NP_001363281 NP_001363282 NP_001363283 NP_001363284 NP_001363285 NP_001363286 NP_001363287 NP_001363288 NP_001363289 NP_001363290 NP_001363291 NP_001363292 NP_001363293 NP_001363294 NP_001363295 NP_001363296 NP_001263696 NP_653113 NP_001344157 Location (UCSC) Chr 1: 203.8 – 203.85 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger CCCH domain-containing protein 11A is a protein that in humans is encoded by the ZC3H11A gene. ^{[4] [5]} ZC3H11A is a part of the transcription export (TREX) complex and plays a role in exporting of mRNAs from nucleus to cytoplasm. ^[6] It is considered as stress-induced nuclear protein and maintains mRNAs exporting when the cells are under stress. ^[7] Loss of functioning of ZC3H11A gene in HeLa cells results in abortion of the replication of nuclear replicating viruses but not cytoplasmic replicating viruses. ^[8] It is discovered that ZC3H11A is significant for viability and metabolic regulation of mouse embryo ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000058673 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
5. "Entrez Gene: ZC3H11A zinc finger CCCH-type containing 11A".
6. Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R (23 August 2012). "The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export". PLOS ONE. 7 (8): e43804. Bibcode:2012PLoSO...743804F. doi: 10.1371/journal.pone.0043804 . PMC   3426524 . PMID   22928037.
7. Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, et al. (April 2018). "Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth". Proceedings of the National Academy of Sciences of the United States of America. 115 (16): E3808 –E3816. Bibcode:2018PNAS..115E3808Y. doi: 10.1073/pnas.1722333115 . PMC   5910864 . PMID   29610341.
8. Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, et al. (April 2018). "Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth". Proceedings of the National Academy of Sciences of the United States of America. 115 (16): E3808 –E3816. Bibcode:2018PNAS..115E3808Y. doi: 10.1073/pnas.1722333115 . PMC   5910864 . PMID   29610341.
9. Younis S, Jouneau A, Larsson M, Oudin JF, Adenot P, Omar J, et al. (June 2023). "Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes". Proceedings of the National Academy of Sciences of the United States of America. 120 (23): e2216799120. Bibcode:2023PNAS..12016799Y. doi:10.1073/pnas.2216799120. PMC   10266022 . PMID   37252988.

Further reading

• Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. (February 2001). "The sequence of the human genome". Science. 291 (5507): 1304–1351. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID   11181995.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.