ZCCHC8

ZCCHC8
Identifiers
Aliases	ZCCHC8 , zinc finger CCHC-type containing 8, PFBMFT5
External IDs	OMIM: 616381; MGI: 1917900; HomoloGene: 32349; GeneCards: ZCCHC8; OMA:ZCCHC8 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.31 Start 122,471,599 bp [1] End 122,501,073 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 123,836,357 bp [2] End 123,859,163 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell oocyte gingival epithelium secondary oocyte amniotic fluid tibia skin of thigh visceral pleura germinal epithelium Top expressed in zygote secondary oocyte primary oocyte renal corpuscle spermatid granulocyte neural layer of retina medullary collecting duct tail of embryo thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding zinc ion binding metal ion binding nucleic acid binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleoplasm nuclear body nucleus nucleolus TRAMP complex Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55596 70650 Ensembl ENSG00000033030 ENSMUSG00000029427 UniProt Q6NZY4 Q9CYA6 RefSeq (mRNA) NM_017612 NM_001350935 NM_001350936 NM_001350937 NM_001350938 NM_027494 RefSeq (protein) NP_060082 NP_001337864 NP_001337865 NP_001337866 NP_001337867 NP_081770 Location (UCSC) Chr 12: 122.47 – 122.5 Mb Chr 5: 123.84 – 123.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger CCHC domain-containing protein 8 is a protein that in humans is encoded by the ZCCHC8 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000033030 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029427 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: ZCCHC8 zinc finger, CCHC domain containing 8".

Further reading

• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gustafson MP, Welcker M, Hwang HC, Clurman BE (2006). "Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins". Biochem. Biophys. Res. Commun. 338 (3): 1359–67. doi:10.1016/j.bbrc.2005.10.090. PMID   16263084.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Matsuoka S, Ballif BA, Smogorzewska A, et al. (2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID   17525332. S2CID   16648052.